Navigation Links
ECLIPSE Data on Effects of Otsuka's Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients' Hemodynamics and Urine Output Featured in Heart Failure Society of America's Late Breaking Trials
Date:9/19/2007

out ECLIPSE

ECLIPSE is an international, multicenter, randomized, placebo-controlled single-dose trial conducted at 48 trials sites in United States, Romania and Bulgaria between 2005 and 2006. ECLIPSE investigators enrolled patients with heart failure (New York Heart Association Class III or IV) for at least three months duration due to left ventricular systolic dysfunction and who had a left ventricular ejection fraction (LVEF) of 40 percent or less.

Investigators assessed patients' inclusion criteria for up to two weeks prior to randomization. Suitable candidates underwent insertion of a balloon- floatation pulmonary artery catheter to assess final eligibility criteria. Final doses of cardiac concomitant medications were administered at least two hours prior to catheter insertion. Following catheter insertion, patients entered into a two- to 20-hour stabilization period. Researchers completed hemodynamic assessments periodically during this period to determine final subject eligibility. Potential participants then entered a two-hour baseline period. If a participant met all criteria during the baseline period, he or she was randomly assigned to one of four groups and received a single once- daily oral tablet of placebo or of 15, 30 or 60 milligrams (mg) tolvaptan. Investigators followed participants for up to 24 hours for assessments.

"The ECLIPSE data add` to our existing knowledge about tolvaptan and its prospective uses," said Taro Iwamoto, CEO, COO and President of Otsuka Pharmaceutical Development & Commercialization, Inc. "Tolvaptan, as one of our most advanced candidate therapies, represents the successful application of Otsuka's expertise in the research and development of new medicines."

About Heart Failure

More than 14 million people in Europe(1) and five million U.S. residents(2) have heart failure (HF), a serious chronic condition in which the heart cannot effectively pump blood. The direct and indirect U.S. health care e
'/>"/>

SOURCE Otsuka America Pharmaceutical, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Landmark Findings From ECLIPSE Program Show Improved Control of Perioperative Hypertension Reduces Risk of Death In Cardiac Surgery
2. Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Childrens Hospital and Stanford
3. Promising Data on Cognitive Effects of Safinamide in Early Parkinsons Disease
4. XYOTAX More Cost Effective With Fewer Side Effects Than Gemcitabine or Vinorelbine in Treating Non-Small Cell Lung Cancer
5. Repros Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism
6. New Data Suggests Less Abuse-Related Effects For OROS Methylphenidate
7. New Long-Term Data Analyses for Bifeprunox Show Favorable Effects Versus Placebo in Stabilized Patients with Schizophrenia
8. The International Myeloma Foundation Says New Clinical Trial Results Could Improve Survival While Reducing Side Effects For Many Patients
9. Studies Show Mild Hyperthermia Enhances Antitumor Effects of Alfacells Onconase
10. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
11. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014  Today the US Surgeon General issued the most ... or sun burns stating they can lead directly to deadly ... Lushniak , says that "skin cancer is a major public ... exposure to indoor and outdoor ultraviolet light is a major ... in Boca Raton, Florida , Marta ...
(Date:7/30/2014)... 30, 2014  El Camino Hospital, a leader in ... utilizing the Leaf Patient Monitoring system to help prevent ... of patients susceptible to bed sores. The ... study of the system, which showed dramatic improvement in ... regularly is the one of the most effect ways ...
(Date:7/30/2014)... , July 30, 2014 Reportlinker.com ... available in its catalogue: mHealth and ... http://www.reportlinker.com/p0356852/mHealth-and-Home-Monitoring-–-6th-Edition.html Executive summary ... delivered, leading to better outcomes, decreased costs and ... for mHealth solutions is still in an early ...
Breaking Medicine Technology:Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3mHealth and Home Monitoring - 6th Edition 2mHealth and Home Monitoring - 6th Edition 3mHealth and Home Monitoring - 6th Edition 4mHealth and Home Monitoring - 6th Edition 5mHealth and Home Monitoring - 6th Edition 6mHealth and Home Monitoring - 6th Edition 7mHealth and Home Monitoring - 6th Edition 8mHealth and Home Monitoring - 6th Edition 9mHealth and Home Monitoring - 6th Edition 10mHealth and Home Monitoring - 6th Edition 11
(Date:7/30/2014)... 30, 2014 LTC Consumer, an independent, free ... care insurance, features an Instant Quote tool on its website, ... of LTC Consumer. Quotes are free and unlimited. , The ... only seven areas – including age, gender, and state of ... seconds (you don’t need to enter any contact information to ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Children’s Hospital ... celebrate Safety Day from 4 p.m. to 7 p.m. ... (29580 7 Mile Road, Livonia, MI 48152). The event ... bike helmets, children’s activities, music, snacks and local public ... to the Children’s Hospital of Michigan Foundation. , ...
(Date:7/30/2014)... the Monterey Bay Aquarium Research Institute (MBARI) have observed ... one half yearslonger than any other known animal. Throughout ... guarded them from predators. This amazing feat represents an ... octopuses of having plenty of time to develop within ... years with little or no food. , Every few ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 The report ... Others), by Application (Healthcare, Food, Water Treatment, Pulp & ... & ROW) - Global Trends & Forecasts to 2018". ... size of 229.54 kilotons by 2019, signifying a robust ... study. , Browse 83 market data tables and 33 ...
(Date:7/30/2014)... 2014 (HealthDay News) --,Although the vast majority of kids ... still wired very differently from children who have trouble ... processing disorders (SPD) can be overly sensitive to sound, ... skills and show a lack of concentration. Complicating ... than others. Some have trouble tolerating loud noises, like ...
Breaking Medicine News(10 mins):Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 3Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 4Health News:Deep-sea octopus broods eggs for over 4 years -- longer than any known animal 2Health News:Deep-sea octopus broods eggs for over 4 years -- longer than any known animal 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 2Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 4Health News:Different Areas of Brain Affected in Autism, Sensory Disorders 2Health News:Different Areas of Brain Affected in Autism, Sensory Disorders 3
... Study says quality years could be extended with more elder-care ... the 15 established European Union countries have a longer life ... of 50 than those in the 10 newer EU nations, ... domestic product (GDP) and spending on elderly care, the more ...
... improve the management of coronary heart disease (CHD) and ... care, according to Dr. Christopher Millett, Consultant in Public ... in the UK, and his colleagues. Their evaluation(1) of ... UK for the management of coronary heart disease, with ...
... complicated tasks and helps people recover learning they otherwise thought ... at the University of Chicago shows. , Using a test ... the first time that people who had "forgotten" how to ... those abilities were restored after a night,s sleep. , "Sleep ...
... growing database marketing agencies, announced that it received a new contract ... arthritis research in the world. , ... Columbia, Md. ... the nation,s largest and fastest growing database marketing agencies, announced that ...
... with Indoor Allergy Week to raise awareness of how ... is often very polluted with unwanted allergens and bacteria. ... it is essential to clean the air in the ... sneeze, spreading to other people in the room, This ...
... new study provides the best evidence to date that ... not only improves their health it actually increases ... University,s Comprehensive Cancer Center found that patients participating in ... breast cancer by 56 percent after an average of ...
Cached Medicine News:Health News:Established EU Countries Healthier Than Newcomers 2Health News:Money motivates doctors to reduce ethnic differences in heart disease treatments 2Health News:Sleep helps people learn complicated tasks 2Health News:Sleep helps people learn complicated tasks 3Health News:Arthritis Foundation Renews Comprehensive Marketing Contract with Merkle 2Health News:Arthritis Foundation Renews Comprehensive Marketing Contract with Merkle 3Health News:Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen 2Health News:Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen 3Health News:Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen 4Health News:Intervention program boosts survival in breast cancer patients 2Health News:Intervention program boosts survival in breast cancer patients 3Health News:Intervention program boosts survival in breast cancer patients 4
Grafton Trial Frame...
Classic Trial Frames UB3 that has long set the standard....
Fitment fine fits handles SF1, SF2, SF3, SF4, SF13 and SF23. Sterile blade....
... Bad-Parker blades offer the superior cutting ... technology, plus the exclusive Rib-Back design ... Brad-Parker brand producer offer the wide ... disposable scalpels. Every blade is packaged ...
Medicine Products: