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Dynavax Presents New Analysis of TOLAMBA(TM) Data at ACAAI Meeting
Date:11/12/2007

Analysis Points to Appropriate Patient Selection Criteria for Future Field

Trial of TOLAMBA

BERKELEY, Calif., Nov. 12 /PRNewswire-FirstCall/ -- Dynavax Technologies Corporation (Nasdaq: DVAX) presented yesterday a detailed analysis of data from the company's large-scale DARTT (SAR09) trial evaluating TOLAMBA(TM), a novel therapy for ragweed allergic rhinitis. The data were reported yesterday at the annual meeting of the American College of Allergy, Asthma and Immunology (ACAAI) in Dallas, TX. Dynavax explained that the data extend the company's understanding of the correlation between skin test parameters and the magnitude of ragweed allergic rhinitis symptoms in placebo-treated patients. Specifically, further analysis of the placebo group in the DARTT trial indicated that concomitant use of two parameters of skin test positivity could enable the selection of patients with substantially increased levels of ragweed specific symptoms.

Abstract presenter, Dr. Eduardo Martins, Vice President Clinical Development at Dynavax, indicated, "The DARTT dataset provided an opportunity to assess the correlation between various skin test parameters at enrollment and the development of meaningful symptoms in placebo patients upon exposure to ragweed. This analysis has provided valuable insights to guide the design of a potential future field study of TOLAMBA and increase the likelihood of enrolling symptomatic patients."

Dr. Martins continued, "A pre-specified subset analysis of patients in the Midwest showed a correlation between higher rhinitis symptoms in the placebo group and measurable efficacy in the TOLAMBA-treated group. Data from the current analysis provide additional support
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SOURCE Dynavax Technologies Corporation
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