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Dynamic Reciprocity Examined as Scientific Framework for Wound Healing in March/April Issue of Wound Repair and Regeneration
Date:4/5/2011

amic and reciprocal processes that modulate wound healing."

Chronic wounds (e.g., pressure ulcers, vascular ulcers and diabetic ulcers) are a major health care burden–with an estimated $5-7 billion spent each year on their treatment in the United States alone–yet the key factor(s) that cause wounds to fail to heal are not well understood. During normal wound healing, interactions between cells and the extracellular matrix are continually changing in a reciprocal and dynamic manner that regulates the phases of healing and determines the outcome of the repair process. In difficult-to-heal or chronic wounds, this process–called dynamic reciprocity–becomes disrupted and the wound fails to proceed through the sequential phases of healing in a timely fashion. Although dynamic reciprocity occurs in these wounds, it doesn't proceed in the expected sequence and doesn't result in the normal pattern of healing. Currently, clinicians do not have diagnostic markers to evaluate the status of dynamic reciprocity processes in their patients' wounds.

"One of our goals with this manuscript is to re-consider some hypotheses that attempt to explain chronic wound pathophysiology and how these might be understood within the framework of dynamic reciprocity," noted Gregory Schultz, PhD, professor in the Department of Obstetrics and Gynecology, at the University of Florida, Gainesville, and an author on the manuscript. "We hope this contribution to the literature will encourage our colleagues to give consideration to the implications of dynamic reciprocity for clinical wound healing and future therapeutic development."

Healthpoint Biotherapeutics provided financial support for the development of the manuscript as part of its support for the Dynamic Reciprocity Work Group. The charter of the DRWG is to promote basic and clinical research related to the dynamic reciprocity of wound healing in order to yield relevant insights into (i) wound
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SOURCE Healthpoint Biotherapeutics
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