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Dynamic Reciprocity Examined as Scientific Framework for Wound Healing in March/April Issue of Wound Repair and Regeneration
Date:4/5/2011

FORT WORTH, Texas, April 5, 2011 /PRNewswire/ -- Healthpoint Biotherapeutics today announced that a new scientific review titled, Dynamic Reciprocity in the Wound Microenvironment, has been published in the March/April issue of Wound Repair and Regeneration. The manuscript authors–Drs. Gregory Schultz, Jeffrey Davidson, Robert Kirsner, Paul Bornstein and Ira Herman–are members of the Dynamic Reciprocity Work Group (DRWG), a scientific exploration committee convened by Healthpoint in 2008.

Interactions between cells, the extracellular matrix (ECM) and other components of the cellular microenvironment underlie all forms of tissue development, from normal developmental processes such as embryogenesis to pathological processes such as carcinogenesis. This ongoing, bi-directional process is referred to as dynamic reciprocity.  

Because wound healing involves tissue development, it is also characterized by dynamic reciprocity between cells and the ECM—the structural and functional complex that surrounds cells and binds them in tissue. These carefully orchestrated interactions are disrupted in difficult-to-heal or chronic wounds, which exhibit many defects that can alter the normal communication between cells and ECM.

"It is our hypothesis that the concept of dynamic reciprocity provides a framework within which to understand the processes that are intact and functional within acute or healing wounds, but are disrupted or dis-equilibrated in chronic wounds," explains Ira Herman, PhD, tenured professor and director, Center for Innovations in Wound Healing Research, Tufts University School of Medicine, director, Cellular and Molecular Physiology Program, Sackler School of Graduate Biomedical Sciences, Tufts University, and an author on the manuscript. "Since disruptions of normal cell-extracellular matrix interactions occur during the wound healing process, we can consider each of these events as specific examples of dyn
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SOURCE Healthpoint Biotherapeutics
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