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Drug Discovery Technologies, BCC Research
Date:9/6/2012

(%) 48

Market Evaluation for Drug Discovery in Epigenetics

Research 48

TABLE 15 GLOBAL MARKET FOR RESEARCH AND DRUG

DISCOVERY IN EPIGENTICS, THROUGH 2017 ($ BILLIONS) 49

TABLE 16 SALES OF FOUR EPIGENETIC DRUGS, 2009–2011 ($

MILLIONS) 50

SUMMARY AND EVALUATION OF GENOMICS-BASED DRUG

DISCOVERY TECHNOLOGY MARKET 51

TABLE 17 GLOBAL MARKET FOR GENOMICS-BASED DRUG

DISCOVERY PLATFORMS, THROUGH 2017 ($ BILLIONS) 51

CHAPTER FIVE: PROTEOMICS RESEARCH AS A DRUG DISCOVERY

TECHNOLOGY AND PLATFORM 52

OVERVIEW 52

PROTEOMICS TECHNOLOGIES THE IN DRUG DISCOVERY

MARKET 53

PROTEIN ISOLATION AND IDENTIFICATION

TECHNOLOGY FOR BIOMARKER OR DRUG TARGET

DISCOVERY 53

Size Exclusion Chromatography 54

Separation Based on Charge or Hydrophobicity 54

Affinity Chromatography 55

Immunoaffinity Chromatography 55

High-Performance Liquid Chromatography as One of the

Main Technologies in Proteomics Drug Discovery 55

High-Performance Liquid (Continued) 56

Sample Injectors 57

Pumps 57

Columns 57

TABLE 18 GLOBAL HIGH-PERFORMANCE (OR HIGH-PRESSURE)

LIQUID CHROMATOGRAPHY (HPLC) MARKET, THROUGH 2017 ($

BILLIONS) 58

TABLE 19 PERCENTAGE OF CUSTOMER DISTRIBUTION IN

COLUMN SEPARATION MARKET IN 2011 59

PROTEIN IDENTIFICATION AND CHARACTERIZATION

TECHNIQUES IN PROTEOMICS DRUG DISCOVERY 59

Mass Spectrometry and the Drug Discovery Sector 59

Mass Spectrometry Instruments 60

Ionization Procedure 60

Matrix-Assisted Laser Desorption/Ionization

(MALDI) 61

Electrospray Ionization (ESI) 61

Atmospheric Pressure Chemical Ionization

(APCI) 61

Mass Analyzers 62

Quadrupole 62

Time-of-Flight Mass Spectrometry 62

Quadrupole—Time-of-Flight (Q-TOF) 63

Ion Trap Mass Spectroscopy 63


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