Drug Development Program Started Based on CAP(R) Human... ( COLOGNE Germany March 3 /- ...)

Drug Development Program Started Based on CAP(R) Human Cell Line

Date:3/3/2009

COLOGNE, Germany, March 3 /PRNewswire/ --

- New Platform May Provide Solutions for Many RA-Patients Around the World

Alloksys Life Sciences BV (Bunnik, The Netherlands), CEVEC Pharmaceuticals GmbH (Cologne, Germany) and PharmaCell BV (Maastricht, The Netherlands) announce the start of Theraptech, a 2.4 million Euro therapeutic protein development program subsidized under the European Trans Bio Program. The major objective of the Theraptech project is to develop a recombinant human alkaline phosphatase (rhuAP) using the novel versatile human CAP(R) cell line, which has been shown to efficiently express glycosylated proteins. The rhuAP produced in CAP(R) cells is expected to feature improved pharmacokinetic and safety profile allowing for repeated dosing of alkaline phosphatase in chronic diseases. Based on a the anti-inflammatory mechanism of action of alkaline phosphatase towards e.g. TNFa, IL-6 and IL-8, as shown in both pre-clinical and clinical studies in acute conditions, we propose it to be developed as a therapeutic protein in major chronic diseases such as Rheumatoid Arthritis. The combined expertise of the members participating in the consortium covers the entire spectrum of activities needed to drive the project from molecular biology to GMP-production and recombinant product testing in preclinical and clinical trials, pushing towards a clinical phase II compliant product within the 3-year-time frame of the project.

Commenting on this unique co-operation, PharmaCell's CEO, Maurice Horsten, commented "Combining the strengths of our companies provides us with an excellent opportunity to build on PharmaCell's motto Humanizing Medicine(R) and to push this important project forward to the benefit of many patients around the world."

Cevec's CEO Dr Rainer Lichtenberger added: "CEVEC is excited about the strong scientific and commercial prospects of the Theraptech project. rhuA
'/>"/>

SOURCE CEVEC Pharmaceuticals GmbH
Copyright©2009 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3
Related medicine technology :

1. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
2. Promising Cystic Fibrosis Compound on Track for Development
3. Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
4. CuraGen Provides Update on Velafermin, Belinostat and CR011-vcMMAE Clinical Development Programs
5. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
6. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
7. New Company Starts, Bridging the Development Gap in the Discovery of Cancer Drugs
8. Quest Diagnostics Introduces ClariSure(TM) Test for Identifying Chromosome Abnormalities Associated With 85 Developmental Disorders in Children
9. WorldHeart Announces Further Milestone in Miniaturized Assist Pump Development
10. EntreMed Raises $20 Million to Support Clinical Development Program
11. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development

Post Your Comments:

(Date:5/21/2013)... , May 21, 2013 Vasomedical, Inc. (OTC BB: VASO) ... design, manufacture and sale of medical devices and in the ... Jun Ma , President and CEO of ... MicroCap Conference on Thursday, May 30, 2013 in ... The Company,s presentation is scheduled to begin ...

(Date:5/21/2013)... 2013 Reportlinker.com announces that a ... its catalogue: ... Coherence Tomography (OCT) http://www.reportlinker.com/p01187977/Global-Markets-and-Technologies-for-Optical-Coherence-Tomography-OCT.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging ... BCC,s aim ... synopsis of the current and future characteristics ...

(Date:5/21/2013)... , May 21, 2013 Janssen R&D Ireland ... from the global Phase 3 PROMISE study demonstrating ... (TMC435) led to sustained virologic response 12 weeks ... percent of treatment-experienced genotype 1 chronic hepatitis C ... stages of liver fibrosis, when administered once daily ...

[0] Vasomedical, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference [0] Global Markets and Technologies for Optical Coherence Tomography (OCT)[0] Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients

... , Beverage Can Stay-Tabs Pose Swallowing Risk ... reports that beverage can stay-tabs pose a potential ingestion risk. ... after safety concerns about pull-tabs. The new study found 19 ... teenagers. Further, the study found that most ingested stay-tabs are ...

... , CHICAGO, Nov. 30 A large ... receive unindicated and unnecessary additional image acquisition resulting in ... today at the annual meeting of the Radiological Society ... of all physicians who work with ionizing radiation to ...

Cached Medicine Technology:Monday, Nov. 30: News From the 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) in Chicago 2 Monday, Nov. 30: News From the 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) in Chicago 3 Unindicated CT Series Result in Unnecessary Radiation Exposure for Patients 2 Unindicated CT Series Result in Unnecessary Radiation Exposure for Patients 3

Monday, Nov. 30: News From the 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) in Chicago Unindicated CT Series Result in Unnecessary Radiation Exposure for Patients

(Date:5/21/2013)... CA (PRWEB) May 21, 2013 Global ... organization, and Bodybuilding.com, the largest online retailer of health ... a new reality-based sports show, Warrior Island. “We ... on; YouTube, Facebook & Twitter, with our unique social ... Island maroons these elite fighters on an island in ...

(Date:5/21/2013)... Boston, Mass.By studying the roles two proteins, thrombospondin-1 ... trans-Atlantic research team has identified a five-amino acid ... in mouse models of prostate, breast and lung ... could potentially block metastasis in a variety of ... Randolph Watnick, PhD, at Boston Children,s Hospital, Vivek ...

(Date:5/21/2013)... or the removal of the adenoids and tonsils, is ... often as a treatment for children with obstructive sleep ... child,s attention and executive functioning, behavior, sleep apnea symptoms, ... until now. A study led by Susan Redline, ... and Cardiovascular Medicine and Associate Clinic Director of the ...

(Date:5/21/2013)... Go Classy Tours, the oldest and ... redesigned their website featuring N Resort in Jamaica ... bars and dining. The website, which has always featured ... guest reviews, will now have a broader range of ... on culinary local recipes, flora and fauna, featured pictures ...

(Date:5/21/2013)... 2013 The American Diabetes Association ( ... the United States of America are affected with peripheral ... great risk of developing peripheral neuropathy which unfortunately makes ... ADA further goes on saying that the disease usually ... 2 million new cases are diagnosed every year in ...

Breaking Medicine News(10 mins):Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 2 Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 3 Health News:Changing cancer's environment to halt its spread 2 Health News:Changing cancer's environment to halt its spread 3 Health News:Early removal of adenoids and tonsils can help pediatric sleep apnea symptoms 2 Health News:The Oldest and Original Nudist Travel Agency for NResort Announced Today a Redesigned Website Featuring Information on Culinary Events, Flora and Fauna, and Photography 2 Health News:Neuracel Aims to Reduce Peripheral Neuropathy Pain 2

[0] Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island [0] Changing cancer's environment to halt its spread [0] Early removal of adenoids and tonsils can help pediatric sleep apnea symptoms [0] The Oldest and Original Nudist Travel Agency for NResort Announced Today a Redesigned Website Featuring Information on Culinary Events, Flora and Fauna, and Photography [0] Neuracel Aims to Reduce Peripheral Neuropathy Pain

... that points to a new strategy for preventing or possibly ... and tissue damage researchers at the University of ... molecule called Epac (Exchange protein activated by cAMP1), plays a ... The research will be published in the online edition ...

... Specialized Bicycles; Goodby, Silverstein & Partners;, and Google Challenged Participants ... ... ROCK, Ark., April 22 The William J. Clinton,Presidential Center and ... April 26., This year,s festival will host "The Aquaduct: Mobile ...

... of the Cycling Event for the,5th Consecutive Year, ... Store, America,s leading supplier of power wheelchairs and,scooters, raised ... Multiple,Sclerosis Society by participating in the MS150 bike ride., ... a Platinum Sponsor of,the two-day cycling journey from Houston ...

... Abbott (NYSE:,ABT) will present at the Morgan ... 2008. Thomas C. Freyman, executive vice,president, finance and ... company at 7:30 a.m. Central time., A ... accessible through,Abbott,s Investor Relations Web site at ...

... PA, NC, SC, GA and,FL, WEST POINT, ... not-for-profit senior living,organization, announced today that it has ... Cove, a continuing care retirement community (CCRC),in Huntsville, ... May 30., Following the closing of this ...

... in radiology and medical image and information management,solutions, today announced it will ... before the market opens on,Thursday, May 1, 2008., ... -- Thursday, May 1, 2008 ... 7:30 a.m. ...

Cached Medicine News:Health News:Scientists identify novel way to prevent cardiac fibrosis 2 Health News:Clinton Center's Earth Day to Feature 'Innovate or Die Contest' Winner 2 Health News:The SCOOTER Store and Their Employees Contribute $43,000 in MS150 Bike Ride to Help Texans With Multiple Sclerosis 2 Health News:PA-Based ACTS Retirement-Life Communities Announces Agreement to Acquire Carlton Cove in Huntsville, Alabama 2 Health News:AMICAS Schedules First Quarter 2008 Earnings Call 2

Scientists identify novel way to prevent cardiac fibrosis Clinton Center's Earth Day to Feature 'Innovate or Die Contest' Winner The SCOOTER Store and Their Employees Contribute $43,000 in MS150 Bike Ride to Help Texans With Multiple Sclerosis Abbott to Present at Morgan Stanley Global Healthcare Unplugged Conference PA-Based ACTS Retirement-Life Communities Announces Agreement to Acquire Carlton Cove in Huntsville, Alabama AMICAS Schedules First Quarter 2008 Earnings Call

... is the cycler that revolutionized thermal cycling. ... consistent results, experiment-to-experiment and block-to-block. This rugged ... it's a platform for new features and ... thermal cycler chassis, does not include the ...

... The Gene Cycler unit is an inexpensive personal ... for the PCR process. Lightweight, with a small ... almost anywhere, including the researcher's desk. , The ... researchers who do not have access to a ...

Contains: Card, cabling and instructions to remotely access a RoboCycler® instrument from a PC or Macintosh® computer...

... Ideal for day-to-day temperature ... of 0.1C ,30% reduction ... Peltier or coolant-based cyclers ... temperature ramping ,Options for ...

Medicine Products:

DNA Engine thermal cycler chassis Gene Cycler Thermal Cycler RoboCycler® RS232 Option Robocycler 40 Temperature Cycler