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Dronedarone (Multaq(R)) Reduced the Incidence and Duration of Hospitalization in Patients with Atrial Fibrillation
Date:11/11/2008

safety profile as evidenced by a low incidence of pro-arrhythmia (including torsades de pointes) and extra-cardiac organ toxicity. Dronedarone, discovered and developed by sanofi-aventis, has been studied in a clinical development program including more than 6,200 patients. Dronedarone is one of the major therapeutic innovations in atrial fibrillation for the last twenty years. Dronedarone (Multaq(R)) has been granted a priority review by the U.S. Food and Drug Administration (FDA) and a registration dossier is also under regulatory review by the European Medicines Agency (EMEA).

About sanofi-aventis

Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes therapeutic solutions to improve the lives of everyone. Sanofi-aventis is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY). For more information, visit: http://www.sanofi-aventis.us or http://www.sanofi-aventis.com

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Marisol Peron

Tel: 908-981-6565 - Mobile: 908-672-9051 - email: marisol.peron@sanofi-aventis.com

US.DRO.08.10.024.

(1) Singh et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. N Engl J Med. 2007 Sep 6;357(10):987-99

(2) Davy JM. Herold M et al. Dronedarone for the control of ventricular rate in permanent atrial fibrillation: the Efficacy and safety of dRonedArone for the control of ventricular rate during atrial fibrillation (ERATO) study. Am Heart J. 2008 Sep;156(3):527.e1-9.

(3) Le Heuzey, Jean-Yves MD a,*; Paziaud, Olivier MD a; Piot, Olivier MD b; Ait Said, Mina MD a; Copie, Xavier MD, PhD b; Lavergne, Tho
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