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Dronedarone (Multaq(R)) Reduced the Incidence and Duration of Hospitalization in Patients with Atrial Fibrillation
Date:11/11/2008

darone showed a low risk of pro-arrhythmia and no excess of hospitalizations for congestive heart failure. There was a similar rate of study drug discontinuation between the 2 study groups.

About Atrial Fibrillation

Atrial fibrillation (AF) is a common heart arrhythmia in which the upper chambers of the heart beat in an uncoordinated and disorganised fashion, which can cause palpitations, shortness of breath and fatigue. Atrial fibrillation (AF) currently represents a major economic burden for society(3). 70 percent of the annual cost of AF management is driven by inpatient care and interventional procedures(4). Hospitalizations for AF have increased dramatically (2- to 3-fold) in recent years(5). AF hospitalizations now represent a third of all hospitalizations for arrhythmia and mortality. AF affects nearly seven million people in the European Union and the United States(6).

The condition is increasingly frequent with advancing age and is often caused by age-related changes in the heart or as a result of cardiovascular disease. AF increases the risk of stroke five-fold and heart failure two- to three-fold. AF also doubles the risk of mortality and is an independent risk factor for sudden cardiac death.

Without appropriate management, AF can lead to serious complications such as stroke and congestive heart failure. In addition to preventing stroke and reducing the burden of the disease, successful management of AF should also aim at further reducing CV morbidity and mortality(7).

The aims of treatment for patients with AF are related to managing the arrhythmia itself and to the prevention of thromboembolism (obstruction of a blood vessel caused by fragments of a blood clot carried from the site of origin to obstruct another vessel). Atrial fibrillation may be treated with medications which either slow the heart rate or revert the heart rhythm back to normal.

About the ATHENA Study

The landmark ATHENA study is the onl
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SOURCE sanofi-aventis
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1. Landmark ATHENA Study Findings With Multaq(R) (dronedarone) Shows 24% Reduction In Cardiovascular Hospitalization or Death in Patients With Atrial Fibrillation
2. ATHENA Clinical Results for Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress
3. ATHENA Clinical Results with Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress
4. Multaq(R) (dronedarone) Granted FDA Priority Review for Patients with Atrial Fibrillation
5. American Heart Journals Publishes Results From ERATO Trial Showing Dronedarone (Multaq(R)) Improves Ventricular Rate Control in Patients With Permanent Atrial Fibrillation
6. Further Analysis From ATHENA Study Showed That Multaq(R)(Dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation
7. Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation
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