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Dr. James F. Pingpank to Present at Leading Regional Therapies Conference
Date:2/19/2009

nt Agreement (CRADA) with the National Cancer Institute. This clinical study is testing Delcath's PHP(TM) System for the regional delivery of melphalan to the liver to treat patients with metastatic cutaneous and ocular melanoma who have unresectable tumors in the liver. The Delcath PHP System(TM) is designed to deliver significantly higher doses of anti-cancer drugs to a patient's liver while preventing entry of the drugs to the rest of the patient's circulation. This isolation limits toxicities that result from systemic chemotherapy treatments.

Patients in the Phase III trial initially are randomized into one of two treatment arms, including immediate treatment with melphalan via the Delcath PHP System(TM) or treatment with best alternative care. The study is designed to evaluate the duration of tumor response in each of the two study arms. Following guidelines established by U.S. Food and Drug Administration under a Special Protocol Assessment (SPA), when disease progresses in patients enrolled in the best alternative care arm of the trial, they are permitted to "cross over" and receive treatment with the Delcath System.

The Fourth International Symposium on Regional Cancer Therapies

The Fourth International Symposium on Regional Cancer Therapies will take place February 21-23, 2009 in Marco Island, Florida. The Symposium is sponsored by the David C. Koch Regional Cancer Therapy Center, the University of Pittsburgh School of Medicine Center for Continuing Education in the Health Sciences and UPMC Cancer Centers. The Koch Regional Cancer Therapy Center is committed to promoting research; development and application of regional cancer therapies; and exchanging information and promoting education among professionals regarding regional cancer therapies. More information on this conference can be found at www.regionaltherapies.com.

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SOURCE Delcath Systems, Inc.
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