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Dr. Eva Feldman, Principal Investigator, Presents Interim Safety Results for Neuralstem ALS Trial
Date:4/12/2011

ll non-ambulatory with permanent paralysis. The first of these was treated on January 20, 2010. Successive surgeries have followed at the rate of one every one-to-two months. The first three patients (Cohort A1) were treated with five unilateral HSSC injections in L2-L4 lumbar segments, while the next three patients (Cohort A2) received 10 bilateral injections in the same region. The next three patients (Cohort B) were all ambulatory and received five unilateral injections in the L2-L4 region.  Since then, two more ambulatory patients have been transplanted, each receiving 10 injections in the same spinal region. Their data was not included in the interim results.

This Phase I safety trial is designed to enroll up to 18 patients. If approved by the FDA and the trial's safety monitoring board (SMB), the trial will progress to cervical transplantation in the summer of 2011.

About Neuralstem

Neuralstem's patented technology enables the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells constitutively into mature, physiologically relevant human neurons and glia. Neuralstem is in a FDA-approved Phase I safety clinical trial for amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig's disease and has been awarded orphan status designation by the FDA.

In addition to ALS, the company is also targeting major central nervous system diseases, including traumatic spinal cord injury, ischemic spastic paraplegia, and Huntington's disease. The company has also submitted an IND (Investigational New Drug) application to the FDA for a Phase I safety trial in chronic spinal cord injury.

Neuralstem also has the ability to generate stable human neural stem cell lines suitable for the systematic screening of large chemical libraries. Through this proprietary screening technology, Neuralstem has discovered and patented c
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SOURCE Neuralstem, Inc.
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