Navigation Links
Discovery yields master regulator of toxin production in staph infections
Date:8/6/2014

fatty acids from the person infected.

Fatty acids are a key component of the phospholipids that make up a significant part of the bacterial membrane. Bacteria produce their own fatty acids, but some, including Staphylococcus aureus, can also borrow from their host, which reduces the demands on bacteria to make their own. Until now, however, the enzyme used to incorporate host fatty acids was unknown.

Researchers showed that different genes carry instructions for making the FAK proteins. Loss of the genes disrupted the ability of bacteria to incorporate host fatty acids into the bacterial membrane. "The big surprise was that loss of these genes also impacted production of virulence factors," Rock said. "The mutant Staphylococcus aureus did not make the proteins responsible for many of the symptoms caused by these infections."

Earlier research from Rock hinted at a connection between fatty acid synthesis and production of virulence factors, but this study is the first to establish the biochemical link and identify the mechanism involved. Evidence suggests that FAK functions in the transcriptional regulation of virulence factor production, switching on genes that carry instructions for making the proteins. "In fact, FAK's primary role in bacteria might be as a transcriptional regulator," Rock said.

Researchers also detailed how FAK handles its duties related to membrane phospholipids. FakA includes the kinase domain, which allows the protein to function as an enzyme. FakB1 binds saturated fatty acids while FakB2 prefers unsaturated fatty acids.

When FakA interacts with either FakB1 or FakB2 a phosphate is transferred onto the FakB fatty acid, producing acyl-phosphate, a chemical intermediate not found in humans. The acyl-phosphate is used as a substitute for fatty acids normally made by the bacteria.

The paper's first author is Josh Parsons, Ph.D., a postdoctoral fellow in Rock's lab
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. TeraDiscoveries to Use its Inverse Design Software Running on Windows Azure to Advance Its Computational Drug Discovery Process
2. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
3. Galenea to Receive $6 Million From The Stanley Medical Research Institute to Progress Pro-Cognitive Drug Discovery and Development Program
4. University Hospitals Case Medical Centers Harrington Discovery Institute Launches Grant Program to Accelerate Drug Discovery and Development
5. Dr. Paul Karila Appointed Head of Discovery Services at Cellectricon AB
6. Aethlon Medical (AEMD) Note: Cancer Research Discovery - Melanoma Exosomes Fuel Organ Metastasis
7. Drug Discovery Technologies Market Soars to $79 billion by 2017, Driven by Innovations in Pipeline and Tools Development
8. AMRI Further Expands Discovery Capabilities in India
9. Tetra Discovery Partners Receives Major NIH Award To Develop New Alzheimers Drug
10. Global Information, Inc. Announces New Market Forecasts For Drug Discovery Industry as it Emerges from Recession
11. Protein and Peptide-based Therapeutics - Trends in Drug Discovery and Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 NxStage Medical, Inc. (NASDAQ: ... products, announced today that the U.S. Food and ... to perform hemodialysis overnight while the patient is ... NxStage,s® System One is the first and only ... indication. Home nocturnal hemodialysis is ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/hmlfbq/investment ) ... Analysis of the US Medical Device Sector " ... http://photos.prnewswire.com/prnh/20130307/600769 This analysis ... identifies the key trends and rationale for undertaking ... and acquisitions. The study will be ...
(Date:12/22/2014)... MARLBOROUGH, Mass , Dec. 22, 2014 /PRNewswire/ -- ... a biotechnology company focused on discovering, developing and ... using RNA-targeted technologies, today issued the following open ... Geert Cauwenbergh , Dr. Med. Sc. ... few days a number of inaccurate statements posted ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3Investment Analysis of the US Medical Device Sector 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6
... Therapeutics, Inc. today,announced completion of a Phase ... kappa opioid agonist, CR845, under development for ... drug candidate was safe and,well-tolerated after intravenous ... expected to be associated with clinical analgesic ...
... CyberKnife System at Oklahoma ... CyberKnife Center, ... global leader in the field of radiosurgery,announced today that the first ... was recently,installed at the Oklahoma CyberKnife, LLC in Tulsa, OK. The ...
Cached Medicine Technology:Cara Therapeutics Announces Successful Completion of Phase I Clinical Trial of Novel Analgesic, CR845 2New CyberKnife Technologies Demonstrate Dramatic Reduction in Treatment Times 2New CyberKnife Technologies Demonstrate Dramatic Reduction in Treatment Times 3New CyberKnife Technologies Demonstrate Dramatic Reduction in Treatment Times 4
(Date:12/26/2014)... It is said that nothing makes a lady ... famous wedding dress supplier, shows its new selection of ... promotion. , UWDress.com’s navy cocktail gowns are the cornerstones ... high fashion styles. Simple dresses in bright neon colors can ... are specially designed for those who want to shine among ...
(Date:12/26/2014)... (PRWEB) December 26, 2014 “Many people ... with personal injury claim issues and phone calls with ... released an article featuring their free eBook on ... helpful eBook on pedestrian and bicycle auto accident claims ... is fully capable of professionally handling their case while ...
(Date:12/25/2014)... December 26, 2014 The microscopy ... of 7.2% to reach $5,756.0 million by 2019. ... microscopy market. The electron microscopes product segment is ... forecast period. , Rising focus on nanotechnology, technological ... of the microscopy market. , Get Full Copy ...
(Date:12/25/2014)... December 25, 2014 Product liability lawsuits ... hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward ... an Order issued in the U.S. District Court, Northern ... convene an open conference on January 7, 2015, at ... Courthouse in West Palm Beach, Florida. The Conference is ...
(Date:12/25/2014)... BellasDress has launched its Christmas Sale, offering ... chosen their best-selling lace wedding dresses, vintage bridesmaid dresses ... , Now, BellasDress.com features popular women’s dresses, and ... prices. The business hopes everyone can have a memorable ... “All our elegant products are made with exquisite materials; ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... Animal Health, LLC, a wholly owned subsidiary of Royer ... MWI Veterinary, Supply, Inc. (Nasdaq: MWIV ) ... III CISPLATIN BEADS and R-GEL ANTIBIOTIC WOUND ... veterinary professionals with localized treatment options for cancer, infections, ...
... shutdown of many public services to head off infections ... confirmed swine flu cases in the United States has surpassed ... believed to be the source of the outbreak -- braced ... to limit further infections in that country, where the virus ...
... April 30 With swine flu topping the agenda ... released,three new maps and indices revealing the countries most ... The Influenza Pandemic Risk Index (IPRI) consists of ... to Contain. Each index,generates a list of countries most ...
... The Providence Service Corporation (Nasdaq: PRSC ... results for its first quarter ended March 31, 2009 on ... a conference call at 11:00 a.m. EDT (9:00 a.m. MDT ... to discuss its financial results and corporate developments. Interested ...
... around the world exercise in unison for 21st annual Project ... across the globe will walk, jog, bike or play games ... ACES (All Children Exercise Simultaneously) Day. This Youth ... American College of Sports Medicine ,s Exercise ...
... STROKE CLINICAL TRIALCARLSBAD, Calif., April 30 PhotoThera, Inc., ... the treatment of acute ischemic stroke within 24 hours ... a $50 million Series D round of financing led ... to fund a planned follow-on phase III ,NEST-3, (NeuroThera(R) ...
Cached Medicine News:Health News:Royer Animal Health Enters Into Exclusive Agreement With MWI Veterinary Supply for U.S. Distribution of Next-Generation Therapeutics to Treat Cancer and Infections 2Health News:Swine Flu Infections Surpass 100 in U.S. 2Health News:Swine Flu Infections Surpass 100 in U.S. 3Health News:Swine Flu Infections Surpass 100 in U.S. 4Health News:Swine Flu Infections Surpass 100 in U.S. 5Health News:Swine Flu Infections Surpass 100 in U.S. 6Health News:Maplecroft Flu Pandemic Maps Reveal Countries Most at Risk 2Health News:Providence Service Corporation to Report First Quarter 2009 Results on Wednesday, May 6th After the Market Closes 2Health News:Providence Service Corporation to Report First Quarter 2009 Results on Wednesday, May 6th After the Market Closes 3Health News:Youth to Fight Obesity With World's Largest Exercise Class 2Health News:Youth to Fight Obesity With World's Largest Exercise Class 3Health News:PhotoThera Closes $50 Million Financing, Announces New President and Chief Executive Officer 2Health News:PhotoThera Closes $50 Million Financing, Announces New President and Chief Executive Officer 3
... a rapid, real-time thermal cycler used for ... automating much of the testing process, and ... is the fastest, easiest to use, and ... The SmartCycler delivers highly accurate and consistent ...
Inquire...
Chemically Resistant Sealing Mat for 384ch, Square Well Available Sterile...
96-well Silicone Compression Mat, Bulk...
Medicine Products: