Navigation Links
Discovery of Marker for Colon Stem Cells Could Shed Light on What Drives Tumor Growth

WILMINGTON, Del., April 7 /PRNewswire/ -- Cancer researchers led by Bruce Boman, M.D., Ph.D. director of Cancer Genetics and Stem Cell Biology at the Helen F. Graham Cancer Center of the Christiana Care Health System, and a faculty member at the University of Delaware, have discovered an enzyme common to both normal and malignant colon stem cells that will assist scientists searching for a cure for colon cancer.

(Logo: )

To date, knowledge of a substance, often referred to as a marker, that enables doctors to identify, locate, and isolate normal and malignant colon stem cells, has been elusive. But the discovery by Dr. Boman and colleagues that aldehyde dehydrogenase 1 (ALDH1) is a marker for identifying and isolating colon stem cells is a potential breakthrough in the search for a key to what drives colon cancer growth.

"This is a very important tool for future research," said Boman, M.D., Ph.D., M.S.P.H., and F.A.C.P., who is also a professor of Medical Oncology at Thomas Jefferson University. "Finding a better way to identify, isolate, and track colon cancer stem cells moves us one step closer to understanding what drives tumor growth and to developing new treatments for advanced colon cancer and ways to prevent colon cancer from developing in the first place."

Dr. Boman adds that his team decided to focus on ALDH1 because it had previously been identified as a marker for leukemias, brain cancers, and breast cancer. The researchers found that ALDH1 is a more specific marker for colon cancer stem cells than are other previously identified candidate markers.

In the study, researchers implanted into mice colon stem cells from seven patients diagnosed with colon cancer, and found that the number of ALDH1 cells increased as the colon cancer progressed.

"Dr. Boman and his team's discovery demonstrates the tremendous strides being made in translational cancer research," says Nicholas J. Petrelli, M.D., Bank of America Endowed Medical Director of the Helen F. Graham Cancer Center. "It is high-impact cancer research like this that allows researchers to translate their discoveries into new tools for physicians to benefit the cancer patients in Delaware and throughout the world."

The research was funded by a grant from the National Institutes of Health, Gregg and Stacey Bacchieri, and the Will and Jeanne Caldwell Fund for Cancer Research at the University of Michigan.

Other researchers on the team in addition to Boman include Emina Huang, of the Department of Surgery at the University of Florida; Mark Hynes, of the Department of Surgery at the University of Michigan; Tao Zhang, of the Department of Biological Sciences of the University of Delaware; Christophe Ginestier, Gabriela Dontu, Henry Appelman and Max S. Wicha of the Comprehensive Cancer Center of the University of Michigan; and Jeremy Z. Fields of CA*TX Biotechnology Inc. in Gladwyne, Pa.

The study appears online on April 7 and in print on April 15 in the journal Cancer Research, published by the American Association of Cancer Research.

SOURCE Christiana Care Health System
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
2. New Company Starts, Bridging the Development Gap in the Discovery of Cancer Drugs
3. Trana Discovery and Southern Research Institute Announce the First RNA-RNA High Throughput Drug Screening Assay Platform for HIV Antivirals
4. ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies
5. ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia
6. Five Clinical Studies to Receive $2.5 Million Under Foundations 2007 Clinical Discovery Program
7. Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.
8. FASgen Announces New Discovery for Treatment of Stroke
9. Nobel Prize-Winning Discovery
10. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
11. FASgen Announces a New Discovery in Obesity Research
Post Your Comments:
(Date:11/25/2015)... , Nov. 26, 2015  The total global healthcare ... 7% over 2015-2016. Latin America has ... , (excluding Japan ), is second ... continues to face increased healthcare expenditure. In 2013-2014, total ... declined from 43.5% in 2008-2009 to 41.2% in 2013-2014. In ...
(Date:11/25/2015)...  Linden Care, LLC, a retail specialty pharmacy focused ... suffering from chronic pain, said today that it is ... (TRO) enjoining Express Scripts from unilaterally terminating the Pharmacy ... --> --> The company said that ... --> --> In ...
(Date:11/25/2015)... Nov. 25, 2015  ARKRAY USA ... to provide evidence demonstrating the accuracy of its blood ... on Insulin Resistance, Diabetes and Cardiovascular Disease in ... the Company,s GLUCOCARD ® 01 meter and the ... requirements. The ability to accurately measure glucose levels in ...
Breaking Medicine Technology:
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from Hopkinsville, ... prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. , The ... medications. In doing so, it could help to prevent potential overdose situations. As ...
(Date:11/27/2015)... Aliso Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... exclusively for use in Final Cut Pro X. With ProSidebar: Fasion, video editors ... banners, or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, ... interesting show that delves into an array of issues that are presently affecting Americans. ... from open dialogue, this show is changing the subjects consumers focus on, one episode ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... largest, most successful and prominent nonprofit healthcare organizations in the country. They have ... with various organizations, and helped advance the healthcare industry as a whole through ...
Breaking Medicine News(10 mins):