Navigation Links
Discovery Labs Releases New AFECTAIR™ Performance Data Presented at the American Association for Respiratory Care Annual Meeting

WARRINGTON, Pa., Nov. 8, 2011 /PRNewswire/ -- Discovery Laboratories, Inc. (Nasdaq: DSCO) today announced that new data supporting AFECTAIR™, the Company's newest product candidate, was presented at the American Association for Respiratory Care (AARC) Congress 2011, internationally recognized as the most relevant medical meeting dedicated to advancing the science and practice of respiratory care. AFECTAIR has been developed by Discovery Labs to simplify the delivery of inhaled therapies for critical care patients requiring ventilatory support. Data from three in-vitro performance studies were presented that assessed the utility of AFECTAIR compared with current standard of care (SoC) ventilatory circuit componentry. Study investigators concluded that use of AFECTAIR:

  • Supported a statistically significant 6 to 14 fold increase (p < 0.05) in the delivery of aerosolized albuterol when compared with the SoC delivery system, suggesting that potential clinical use of AFECTAIR may result in increased delivery of aerosolized medication to patients receiving positive pressure ventilatory support;

  • Resulted in particle size distribution (PSD) of albuterol that spanned the entire respirable range, while the SoC delivery system resulted in PSD at or below the lower end of the respirable range, suggesting that potential clinical use of AFECTAIR may result in increased retention of aerosolized medication in the lung;

  • Did not increase resistance in the ventilator circuitry, suggesting that AFECTAIR may be a comparably safe alternative to SoC devices in ventilator circuits.

"AFECTAIR provides a simplified and more intuitive solution for the delivery of inhaled therapies to patients requiring ventilatory support. Our plan to evaluate the utility of AFECTAIR includes a series of studies with several inhaled therapies. The studies presented at the AARC Congress are the first in the series and we are very pleased with these results," said Dr. Russell G. Clayton, Sr. Vice President, Research & Development. "We believe that AFECTAIR has the potential to address a considerable unmet medical need and become a new standard of care for the delivery of inhaled therapies to patients requiring ventilatory support."


AFECTAIR is a series of proprietary ventilator circuit / patient interface connectors and related componentry. AFECTAIR simplifies the delivery of any inhaled therapies to critical care patients requiring ventilatory support. According to national health statistics and market assessment data, it is estimated that more than 1.3 million patients annually in the United States and European Union receive aerosolized medications while requiring ventilator support. Discovery Labs is implementing a regulatory plan that potentially will allow for the introduction of AFECTAIR in the United States and the European Union in 2012.

About The American Association for Respiratory Care

The American Association for Respiratory Care, headquartered in Dallas, is a professional association of respiratory therapists that focuses primarily on respiratory therapy education and research. The organization's goals are to ensure that respiratory patients receive safe and effective care from qualified professionals as well as supporting respiratory health care providers. The association continues to advocate on behalf of pulmonary patients for appropriate access to respiratory services provided by qualified professionals. Further information about the AARC and how to become a respiratory therapist are available at

About AFECTAIR AARC Congress 2011 Presentations

The following studies were presented:

  • Delivery of Aerosolized Albuterol Using A Novel Aerosol Delivery Adapter In An In-Vitro Neonatal Ventilation Model; Mazela, et al.
    • The objective of this study was to compare the dose of aerosolized albuterol sulfate delivered to lung simulator under various neonatal ventilator settings using the AFECTAIR ventilator circuit patient interface connector versus current SoC delivery system. The investigators observed that use of AFECTAIR resulted in a statistically significant 6 to 14 fold increase (p < 0.05) in the delivery of aerosolized albuterol when compared with SoC, and concluded that potential clinical use of AFECTAIR may result in increased delivery of aerosolized medication to neonates receiving positive pressure ventilatory support.

  • Aerosolized Albuterol Particle Size Distribution In Two Aerosol Delivery System Configurations Under Neonatal Ventilation Conditions; Mazela, et al.
    • The objective of this study was to determine the particle size distribution (PSD) using AFECTAIR versus SoC delivery system to deliver aerosolized albuterol in a neonatal ventilatory circuit. PSD is an important determination for effective aerosolized medication delivery, where the 'optimal PSD' spans the human respirable range of 2-5 microns. The investigators observed PSD at or below the lower end of the respirable range when using the SoC delivery system. In contrast, the PSD observed using the AFECTAIR connector spanned the entire respirable range. These observations suggest that the potential clinical use of AFECTAIR may result in increased delivery and retention of aerosolized medication in the lung.

  • Resistance Determinations of a Novel Aerosol Delivery Adapter in a Neonatal Model; Henderson, et al.
    • The objective of this study was to determine if AFECTAIR impacts respiratory system resistance in a ventilator circuit, compared with SoC connectors currently used in ventilator circuits. The investigators observed that resistance measurements were similar between AFECTAIR and the SoC delivery system and concluded that AFECTAIR may be a comparably safe alternative to SoC in ventilator circuits.

About Discovery Labs

Discovery Laboratories, Inc. is a specialty biotechnology company with one focus – to create life-saving products for critical care patients with respiratory disease and improve the standard of care for pulmonary medicine. Discovery Labs' novel proprietary KL4 surfactant technology produces a synthetic, peptide-containing surfactant that is structurally similar to pulmonary surfactant and is being developed in liquid, lyophilized and aerosolized formulations. Discovery Labs is also developing its proprietary drug delivery technologies to enable efficient, targeted upper-respiratory or alveolar delivery of aerosolized KL4 surfactant and other inhaled therapies. Discovery Labs believes that its proprietary technologies make it possible, for the first time, to develop a significant pipeline of products to address a variety of respiratory diseases for which there frequently are few or no approved therapies. For more information, please visit our website at

Forward Looking Statements

To the extent that statements in this press release are not strictly historical, all such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially from the statements made. Examples of such risks and uncertainties, including those related to Discovery Labs' research and development activities and commercial plans, are described in Discovery Labs' filings with the Securities and Exchange Commission, including the most recent reports on Forms 10-K, 10-Q and 8-K, and any amendments thereto. Except as otherwise required by law, Discovery Labs undertakes no obligation to update or revise any forward-looking statements.

SOURCE Discovery Laboratories, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Quanticel Pharmaceuticals Enters Into Strategic Cancer Drug Discovery Collaboration With Celgene Corporation
2. The Future of GPCRs in Drug Discovery: Novel technologies, leading companies, and opportunities for target expansion
3. GPCRs in Drug Discovery - Efforts to De-Orphanize Novel GPCR Targets are Increasing
4. MUSC Dedicates New Bioengineering and Drug Discovery Hubs
5. SomaLogic Announces Research Agreement with Leading Global Pharmaceutical Company to Accelerate Pharmaceutical Discovery and Development
6. Karyopharm Therapeutics Inc. and Katholieke Universiteit Leuven Sign Exclusive Collaboration for the Discovery of Novel CRM1/Exportin 1 Inhibitors
7. Argos Therapeutics Late Scientific Co-founder Ralph Steinman, M.D., Awarded Nobel Prize in Medicine for Discovery of Dendritic Cells as Critical Sentinels of Immune System
8. St. Jude Childrens Research Hospital Discovery Aided Quest for Adult Cancer Drug
9. Discovery Labs Notified of PDUFA Date for SURFAXIN®
10. Cellular Dynamics Announces Commercial Launch of iCell® Endothelial Cells for Vascular-Targeted Drug Discovery
11. National Library of Medicine Awards Phase I SBIR Grant to Collaborative Drug Discovery, Inc. to Develop Computational Tools for Biocomputation across Distributed Private Datasets to Enhance Drug Discovery
Post Your Comments:
(Date:11/25/2015)... 2015  Linden Care, LLC, a retail specialty pharmacy ... patients suffering from chronic pain, said today that it ... Order (TRO) enjoining Express Scripts from unilaterally terminating the ... --> --> The company said ... options. --> --> ...
(Date:11/25/2015)... 25, 2015 On Tuesday, November 24, ... trial against Wright Medical Technology, Inc. for product ... metal-on-metal hip implant device, awarded $11 million in ... week trial and three days of deliberations, the ... was defectively designed and unreasonably dangerous, and that ...
(Date:11/25/2015)... 25, 2015  Henry Schein, Inc., the world,s largest ... dental, medical and animal health practitioners, will unveil at ... Henry Schein ConnectDental® Pavilion , which brings together for ... solutions designed to help any practice or laboratory enter ... for a schedule of experts appearing at the Pavilion. ...
Breaking Medicine Technology:
(Date:11/26/2015)... Las Vegas, NV (PRWEB) , ... November 26, 2015 , ... ... holiday shopping strategy. Many customers choose to buy during the Black Friday and ... holiday gifts. Shoppers don’t need to search the Internet high and low to find ...
(Date:11/26/2015)... ... November 26, 2015 , ... The Catalent Applied ... the need to integrate dose form selection in early phase drug development. The ... organization supporting and bringing together the UK’s emerging life sciences companies, corporate partners, ...
(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare International, Inc., the first ... annual Employee Benefits Conference. The Employee Benefits Conference was hosted by the International ... November 11th, 2015. The conference was held at the Hawaii Convention Center in ...
(Date:11/26/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the world-class Asterisk based ... efficiency and reliability. , The new Q-Suite 6 platform is based on the latest ... itself into a specific piece of software for many key components of the suite. ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... the perfect dish and pleasing the palates of attendees is of the utmost ... dish to a seasonal get-together, give these recipes a try this holiday season. ...
Breaking Medicine News(10 mins):