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Discovery Labs Presents Final Assessment in a Series of Pharmacoeconomic Analyses that Explore Impact of Reintubation on Healthcare Costs
Date:6/11/2013

expects to submit this analysis to a peer-reviewed, neonatology-focused medical journal later this year.

"A substantial proportion of infants with RDS, especially those under 1,000 grams, need to be reintubated.  The occurrence of major morbidities associated with reintubation in preterm children may potentially have a profound impact on healthcare resource utilization in the neonatal population," said Fernando R Moya, MD, SELECT Trial Principle Investigator and Director of Neonatology at New Hanover Regional Medical Center, Wilmington, NC. "Lower reintubation rates such as those observed with SURFAXIN therapy may significantly lower in-hospital costs for the treatment of reintubated infants."

The series of pharmacoeconomic analyses is based on the observations reported in the first ever, full description of the consequences of reintubation in preterm neonates published in the Journal of Neonatal- Perinatal Medicine (Volume 4, Number 2, 2011).   Those observations include:

  • Infants who were successfully extubated and did not require reintubation had a significantly lower mortality rate compared with infants who subsequently required reintubation (0.5 percent vs. 18 percent, respectively p<0.05).
  • Infants who required reintubation had significantly higher rates of major complications of prematurity, including BPD, air leak, sepsis, NEC and IVH.
  • Infants treated with SURFAXIN demonstrated a significantly lower reintubation rate compared with infants treated with animal-derived surfactants Curosurf (33 percent vs. 47 percent respectively; p<0.05) and Survanta (35 percent vs. 43 percent respectively; p<0.05).
  • Infants treated with SURFAXIN demonstrated a significantly higher combined outcome of survival without reintubation compared with those infants treated with animal-derived surfactants Curosurf (
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SOURCE Discovery Laboratories, Inc.
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