Navigation Links
Difficult-to-Treat Patient Populations Respond Positively to Hepatitis C Treatment
Date:10/28/2009

ALEXANDRIA, Va., and BOSTON, Oct. 28 /PRNewswire/ -- The final results of the PROVE3 study will be presented at this year's annual meeting of the American Association for the Study of Liver Diseases. This phase 2 study was of telaprevir compared to a combination therapy of peginterferon alfa-2a and ribavirin. It intended to measure the 6 month and also 1-year durability of sustained viral response in genotype 1 patients with HCV who failed prior treatment with pegylated interferon and ribavirin.

According to John McHutchison, MD, principal investigator for this study, "This was the first large scale study performed in nonresponders to our current standard of care, which evaluated retreating these patients with the addition of an HCV-specific protease inhibitor. Its importance is, therefore, the proof of principle that adding this potent direct anti-viral allowed us to cure approximately 50 percent of this patient population who have failed therapy and for which no other options currently exists."

The study included 453 patients, and the SVR rates in all treatment groups who received the telaprevir-based therapy were significantly higher than those who received peginterferon alfa-2a and ribavirin. All patients who received telaprevir and achieved virologic response maintained it for 48 weeks after the end of the treatment.

The drug in this nonresponder setting is currently undergoing phase 3 large-scale registration trials to confirm and further elucidate the findings of this current phase 2 study. "To sit across the desk from our hepatitis C patients and tell those that have not responded that with this retreatment strategy they have a 50 percent chance of being cured will be a huge message for patients and providers if confirmed in larger phase 3 clinical trials," concluded Dr. McHutchison.

Abstract title:

PROVE3 final results and 1-year durability of SVR with Telaprevir-based regimen in hepati
'/>"/>

SOURCE American Association for the Study of Liver Diseases (AASLD)
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. ThromboGenics and BioInvent Complete Patient Recruitment of Phase II DVT Prophylaxis Study With Anti-Factor VIII (TB-402)
2. Patients who Participated in Pleio GoodStart(TM) Refilled 30% Sooner and 40% More, Averaging 2 Additional Rx Refills per Patient
3. New Data Show CIMZIA(R) (certolizumab pegol) Provides Sustained and Significant Symptom Improvement in Moderate to Severe Crohns Patients
4. Biomoda Enters Final Stage of Patient Testing for Phase II Lung Cancer Clinical Study
5. Peregrine Pharmaceuticals Reports 61% Objective Response Rate in 46-Patient Bavituximab Phase II Trial in Advanced Breast Cancer
6. Long-Term Data Updates Show Further Extensions of Survival and Delays in Recurrence in Brain Cancer Patients Who Received DCVax(R)-Brain
7. Patients Receiving High Radiation at Cedars Sinai File Class Action Lawsuit
8. Novartis drug Tasigna(R) meets primary endpoint in pivotal trial against Gleevec(R) as first-line treatment in chronic myeloid leukemia patients
9. Patients Taking VIMOVO(TM) Showed a Decrease in Incidence of NSAID-Associated Ulcers
10. ULORIC(R) (febuxostat) Demonstrated Efficacy for Management of Hyperuricemia in Patients with Gout
11. EPIX Pharmaceuticals Announces FDA Approval of a Physician-Sponsored IND for Fourth 6-month Open Label Extension of PRX-03140 for Alzheimers Disease Patient
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... SAN DIEGO , Dec. 17, 2014 ... PHIA) and Volcano Corporation (NASDAQ: VOLC ), a ... applications, today announced that they have entered into a definitive ... tender offer to acquire all of the issued and outstanding ... total equity purchase price of USD 1 billion (approx. EUR ...
(Date:12/17/2014)... Germany , December 17, 2014 ... level of expenditure on research and development In ... increased its revenue by two percent to EUR 4.287 billion ... (EBIT) grew by 14 percent to EUR 360 million. "Overall, ... said Dr. Michael Kaschke , President and CEO of ...
(Date:12/17/2014)... 2014  Northstar Global Business Services, Inc. (OTCPink:MDIN) ... has made their final decision and has determined ... stock effective December 15, 2014, and has resumed ... and book entry transfer services. All deposit restrictions have ... again fully "DTC Eligible", and has resumed electronic ...
Breaking Medicine Technology:Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8ZEISS Asserts its Position in Difficult Environment 2Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3
... 2010 General-use X-ray security systems are one ... to widespread use to check people entering secured ... (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... the low risk to health associated with these ...
... N.Y., Nov. 4, 2010 At a special meeting today, ... approve the merger of West Acquisition Corp., an indirect wholly ... ), with and into Penwest and voted to approve the ... Penwest, West and Endo.   The merger became ...
Cached Medicine Technology:
(Date:12/19/2014)... 19, 2014 If you have ever ... breathing, you probably wished you had an arsenal of ... cystic fibrosis, and other breathing disorders. Currently, the only ... avoiding triggers, but other common treatments do exist. ... in San Antonio, TX, 34 asthma educators responded to ...
(Date:12/19/2014)... December 19, 2014 Slone ... diagnostic, personalized medicine, healthcare information technology, and laboratory ... position of Chief Operating Officer. The announcement comes ... marked by a strengthened presence in Boston and ... "Leslie lives and breathes the client experience," said ...
(Date:12/19/2014)... This is a professional and in-depth ... industry with a focus on the Chinese market. The ... the Gliquidone manufacturers and is a valuable source of ... the industry. , Firstly, the report provides a basic ... manufacturing technology. Then, the report explores the international and ...
(Date:12/19/2014)... December 19, 2014 The Hermitage ... club in Southern Vermont’s Deerfield Valley, announced today that ... by classic rock songs. , Three time Grammy ... a private concert followed by a trail naming ceremony. ... trail names include: “I’m Alright” the theme song for ...
(Date:12/19/2014)... new study suggests a possible link between certain menopause ... sweats -- and higher rates of hip fractures and ... affecting about 60 percent of women. The hormonal changes ... then face a higher risk of weakened bones and ... or severe menopausal symptoms are more likely to have ...
Breaking Medicine News(10 mins):Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 2Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 3Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 2Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 3Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 4Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 5Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 6Health News:The Hermitage Club Officially Names Four Ski Trails after Iconic Rock Songs by Grammy Award Winner Kenny Loggins 2Health News:Severe Hot Flashes During Menopause May Raise Hip Fracture Risk Later: Study 2
... Thailand who was infected by H5N1 bird flu virus and managed ... years old Pranom Thongchan, of Srisomboon, central Thailand, tells her horrific ... was her niece who coughed blood as she passed away in ... attacked her sister, the girl's mother, and she was dead. After ...
... gene, Sipa1, with an amino acid polymorphism that ... often the result of metastasis rather than the ... that the genetic background of the host can ... transgene in various strains of inbred mice and ...
... on mammograms. There are calcium deposits in the media ... called M?nckeberg medial// calcific sclerosis or medial arterial calcification. ... diabetes and cardiovascular risk, but there are few reports ... in Volume 18 (6) of Journal of Diabetes and ...
... meats, red meat and pork can enhance the risk of ... October 5 issue of the Journal of the National Cancer ... of exocrine pancreatic cancer, but previous findings have been inconsistent. ... cholesterol content of meats and to food preparation methods. ...
... as extremely important nutritionally and studied extensively. A ... scientists has revealed new findings about how carotenoids ... to tag carotenoids from kale, researchers at the ... monitored the nutrients' absorption within the body. Physiologist ...
... topic in the health fraternity these days. ,A survey ... concerned about trans-fats than carbohydrates.// ,Among the ... trans-fats, which had been known to raise bad cholesterol ... the US. In comparison, 10 percent strongly wanted to ...
Cached Medicine News:Health News:Bird Flu Survivor Recounts her ‘hell 2Health News:Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis 2Health News:Association Of Breast Arterial Calcifications With Diabetes And Hypertension 2Health News:Intake Of Processed Meat And Fat Associated With Pancreatic Cancer 2Health News:Carotenoid Absorption Explained In A Better Manner 2
... a solid made, manual plate washer ... for dispense and aspirate function ensure ... with a stand and all necessary ... used, as well as any bottles ...
... of microplate washers are precise, fast and ... manifold, providing independent control of both dispense ... and overflow protection in both 96- and ... the most precise and reliable washer available ...
... The Microplate washer MP-1200 is a ... washing system. Its internal micropumps enable ... to discharge from all types of ... to be washed in rows of ...
... throughput washer for high ... throughput system washer is ... powerful dispensing line and ... stronger, external vacuum source. ...
Medicine Products: