Navigation Links
Diabetes drug slows experimental Parkinson's disease progression, human trials to begin next year
Date:12/7/2016

GRAND RAPIDS, Mich., Dec. 7, 2016 /PRNewswire/ -- A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings today in the journal Science Translational Medicine.

"We hope this will be a watershed moment for millions of people living with Parkinson's disease," says Patrik Brundin, M.D., Ph.D., director of Van Andel Research Institute's Center for Neurodegenerative Science, chairman of The Cure Parkinson's Trust's Linked Clinical Trials Committee, and the study's senior author. "All of our research in Parkinson's models suggests this drug could potentially slow the disease's progression in people as well."

Continue Reading
A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings in the journal Science Translational Medicine.
A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings in the journal Science Translational Medicine.
Dopamine-producing brain cells after treatment with MSDC-0160. Photo courtesy of the Patrik Brundin Laboratory, Van Andel Research Institute.
Dopamine-producing brain cells after treatment with MSDC-0160. Photo courtesy of the Patrik Brundin Laboratory, Van Andel Research Institute.
A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings in the journal Science Translational Medicine. Dopamine-producing brain cells after treatment with MSDC-0160. Photo courtesy of the Patrik Brundin Laboratory, Van Andel Research Institute.

Until now, Parkinson's treatments have focused on symptom management. If successful in human trials, MSDC-0160 would be the world's first therapy to treat the underlying disease and slow its progression—potentially improving quality of life and preventing the occurrence of falls and cognitive decline. It may also reduce or delay the need for medications that can have debilitating side effects, says Brundin.

Parkinson's disease afflicts between 7-10 million people worldwide, including an estimated 1 million Americans, and these numbers are expected to increase dramatically as the average human lifespan increases.  There is currently no cure, and first-line treatment has remained relatively unchanged since the introduction of levodopa in the 1960s.

Tom Isaacs, a co-founder of The Cure Parkinson's Trust who has lived with Parkinson's for 22 years, says MSDC-0160 represents one of the most promising treatment the Trust's international consortium has seen to date.

"Our scientific team has evaluated more than 120 potential treatments for Parkinson's disease, and MSDC-0160 offers the genuine prospect of being a breakthrough that could make a significant and permanent impact on people's lives in the near future," says Isaacs. "We are working tirelessly to move this drug into human trials as quickly as possible in our pursuit of a cure."

MSDC-0160 was developed by Kalamazoo, Michigan-based Metabolic Solutions Development Company (MSDC) to treat type 2 diabetes. In 2012, Brundin recognized it as an exciting drug candidate because of its mode of action, proven safety in people, local availability and the start-up company's interest in collaborating on drug repurposing initiatives. After four years of work, the effects of the drug in the laboratory exceeded Brundin's expectations.

The novelty of MSDC-0160 stems from a recently revived revelation that Parkinson's may originate, at least partially, in the body's energy metabolism. The new drug appears to regulate mitochondrial function in brain cells and restore the cells' ability to convert basic nutrients into energy. Consequently, the cells' ability to handle potentially harmful proteins is normalized, which leads to reduced inflammation and less nerve cell death.

"Parkinson's disease and diabetes may have vastly different symptoms with unrelated patient outcomes; however, we're discovering they share many underlying mechanisms at the molecular level and respond similarly to a new class of insulin sensitizers like MSDC-0160," says Jerry Colca, Ph.D., co-founder, president and chief scientific officer of MSDC.

While Brundin says he is eager to see MSDC-0160 launched into a clinical trial in Parkinson's disease, he's equally excited about the possibility of testing the drug in Lewy body dementia and other cognitive decline conditions, such as Alzheimer's disease.

"This is an immensely promising avenue for drug discovery," says Brundin. "Whatever the outcome of the upcoming trial for Parkinson's, we now have a new road to follow in search of better treatments that cut to the root of this and other insidious diseases."

The Cure Parkinson's Trust and Van Andel Research Institute are currently working with MSDC to address regulatory issues and obtain funding to organize the clinical trial, which Brundin hopes can begin sometime in 2017.

Funding for the research was provided by Van Andel Research Institute, The Cure Parkinson's Trust, the Campbell Foundation, and the Spica Foundation.

The paper's authors include Anamitra Ghosh, Trevor Tyson, Sonia George, Erin N. Hildebrandt, Jennifer A. Steiner, Zachary Madaj, Emily Schulz, Emily Machiela, Martha L. Escobar Galvis, Jeremy M. Van Raamsdonk and Patrik Brundin, all of Van Andel Research Institute; William G. McDonald and Jerry R. Colca, both of Metabolic Solutions Development Company; and Jeffrey H. Kordower, of Rush University Medical Center and Van Andel Research Institute.

About Parkinson's disease
Although Parkinson's symptoms vary widely among patients, they typically progress from a constellation of vague problems, including loss of smell, constipation, poor sleep, mood fluctuations, and changing blood pressures, to the disease's hallmarks, such as tremors, affected speech and facial expressions, stooping, poor motor function, and memory loss.

The gold standard treatment, levodopa, supplements the neurotransmitter dopamine, a chemical in the brain that is critical for motor function and one that decreases as the disease progresses. Though often effective early in Parkinson's progression, levodopa's effectiveness may decline and the need to endure increasingly heavy doses comes with debilitating side effects like confusion, anxiety, hallucinations, uncontrollable movements and tremors, and incontinence.

About MSDC-0160
MSDC-0160 is a novel mTOT modulator being developed to treat neurodegenerative diseases such as Parkinson's and Alzheimer's disease. It is a once-a-day, oral insulin sensitizer that works through a new drug target located in the inner mitochondrial membrane, called mTOT. The mTOT mechanism ties mitochondrial metabolism to aspects of the pathology associated with insulin resistance and certain neurodegenerative diseases.

MSDC-0160 has been shown to safe, well-tolerated, and efficacious in a 90-day, randomized, double-blind, comparator- and placebo-controlled, multi-dose Phase 2b clinical study in 258 patients with type 2 diabetes (Clinical Pharmacology & Therapeutics (advance online publication 6 March 2013); and in a Phase 2a study conducted by researchers at Rush University Medical Center in Chicago in patients diagnosed with dementia due to Alzheimer's disease, wherein this new therapeutic agent prevented the decline in a measure of brain glucose utilization in patients with mild to moderate Alzheimer's disease (Current Alzheimer Research, 2014, 11).

Contact: Beth Hinshaw Hall, 616-234-5519, beth.hinshaw@vai.org

Video - https://www.youtube.com/watch?v=9bxVOABKmxk&feature=youtu.be
Photo - http://photos.prnewswire.com/prnh/20161206/446296

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/diabetes-drug-slows-experimental-parkinsons-disease-progression-human-trials-to-begin-next-year-300374483.html


'/>"/>
SOURCE Van Andel Research Institute
Copyright©2016 PR Newswire.
All rights reserved


Related medicine technology :

1. Diabetes & Obesity Drug Development Pipeline Review, 2016
2. Physicians Move Beyond Traditional Tests to Better Manage Diabetes
3. FDA approves Jardiance to reduce cardiovascular death in adults with type 2 diabetes
4. United States Lancet and Lancing Devices Market Report 2016-2017 with Diabetes Monitoring, Treatment And Drug Delivery Market Overview - Research and Markets
5. Unmet Needs in Type 2 Diabetes Mellitus Market Leave Ample Opportunity for Investment, Says GBI Research
6. Emperra Wins Prestigious Award With Innovative Diabetes Device
7. Intarcia Submits New Drug Application (NDA) to FDA for U.S. Marketing Approval of ITCA 650 in Type 2 Diabetes
8. Diabetes Scholars Foundation Announces 2016 Scholarship Recipients
9. Medical Imaging Leaders Tap IBM and Watson to Tackle Cancer, Diabetes, Eye Health, Brain Disease and Heart Disease
10. Canagliflozin Phase 2 Study Demonstrates Glycemic Improvements in Adults With Type 1 Diabetes
11. IBM Watson Health Showcases Progress Tackling Diabetes at American Diabetes Associations 76th Scientific Sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2017)... May 17, 2017  Bayer announced today that the ... be presented at the 53 rd Annual Meeting ... place June 2-6 in Chicago . ... span prostate, colorectal, liver and thyroid cancers, as well ... Phase II CHRONOS-1 trial of copanlisib in patients with ...
(Date:5/15/2017)... 2017 Enterin Inc., a privately-held CNS pharmaceutical company ... compounds to treat Parkinson,s disease (PD), has enrolled the first ... 1/2a randomized, controlled, multicenter study involving patients with PD and ... patients over a 9-to-12-month period. The first stage is open ... PD. Participating sites include Denver , ...
(Date:5/11/2017)...  Thornhill Research Inc. ( Toronto, Ontario, ... USD five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery contract by the U.S. ... (CCC) ( Ottawa, Ontario, Canada ) ... anesthesia to patients requiring emergency medical procedures in ... Corps have been a longtime partner with Thornhill ...
Breaking Medicine Technology:
(Date:5/26/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... the Peace Agreements being discussed by President Donald Trump and the rest of the ... to speed up peace talks in the continuous battle between Israel and Palestine. The ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... “When the ... Lead Home” is the creation of published author Laura Weigel Douglas, an avid reader ... cat in a house that sometimes feels like Green Hills Adventure Camp. She couldn’t ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Cactus Jack: Against All Odds”: ... many others. “Cactus Jack: Against All Odds” is the creation of published author, ... Hubbard is married to Jack Carlisle’s third child Jane. Walter. Walter and Jane ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Dr. Alan ... surgery in New York City. He is known for his distinguished expertise and ... vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular disease and aortic ...
(Date:5/24/2017)... ... ... Dr. Manju R. Kejriwal, a leading Ohio dentist, is now welcoming new ... Dr. Kejriwal understands the emotional and financial toll traditional orthodontics can take on patients’ ... longer need to feel the esthetic effects of wires and brackets when they can ...
Breaking Medicine News(10 mins):