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Device Blocking Stomach Nerve Signals Shows Promise in Obesity
Date:6/26/2008

will," he explains. "In the next study, which has already begun, all patients will have the device implanted, but one-third will not have it turned on during the first year of the study, so that after meals, it won't be blocking the nerve signals; this is called 'sham' treatment. Neither the patients nor their doctors will know whether the blocking signals are going through or not. This 'pivotal' study will tell us whether a placebo effect is responsible for some of the weight loss."

"After the pivotal study is completed, those who had the 'sham' treatment will have their devices turned on so they can experience the benefits," Dr. Camilleri says. "And unlike the first study, participants also will have access to behavioral counseling and dietary modifications, which will lead to a more realistic comparison of the magnitude of weight loss through vagal blockade as compared with bariatric surgery. The findings published this month are promising, but the next study will tell us whether VBLOC therapy is a viable alternative to gastric bypass or gastric banding, and for which patients."

Dr. Camilleri received consulting fees and license payments as part of a formal business relationship between Mayo Clinic and EnteroMedics, Inc. The research was completely funded by EnteroMedics. Mayo Clinic has invested in EnteroMedics and holds a minor equity position.

For additional video and audio resources, connect with Mayo Clinic's News Blog at: http://newsblog.mayoclinic.org/2008/06/23/device-jamming-stomach-nerve-sign al-shows-promise-in-obesity/


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