Navigation Links
Details of HER-2/neu Class I Antigen Licensed by TapImmune published in Journal of Immunology: Antigen is a naturally processed epitope for breast cancer vaccines.
Date:1/22/2013

SEATTLE, Jan. 22, 2013 /PRNewswire/ -- TapImmune Inc. (OTCBB: TPIV) is pleased to announce the January publication of a paper titled "Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T-cells", authored by Henle et al, J.Immunol. (2013), 190, 479-488.  This work, performed in the laboratory of Dr Keith Knutson at Mayo Clinic, describes the discovery of a novel HER-2/neu Class I epitope (p373-382) TapImmune has licensed from Mayo Clinic for the development of breast cancer vaccines.  The significance of this work is that this newly discovered antigen is a naturally occurring antigen processed by the proteasome and elicits peptide-specific T-cell responses.  This results in stronger binding to HLA-A2 and more efficient killing of HER-2/neu positive breast cancer cells by activated T-cells compared to the Class I epitope, p369-377 (E75) which was not naturally processed by the proteasome.

"These results provide an explanation of the molecular immunology behind our approach to HER-2/neu immunotherapy," said Mark Reddish Vice President of TapImmune Inc.  "These data describe how the HER-2/neu protein is processed by the proteasome to then be presented for immune recognition and killing.  By revealing the true identity of the immunodominant epitope responsible for class I mediated killing of HER-2/neu positive tumors, it is now possible to generate a true second generation vaccine that incorporates the correct target as it naturally appears on human tumors.  For nearly 20 years the immunology of this key protein has been clouded by contradictory observations, and these data finally provide an understanding of the 'natural target' displayed on human tumors. We expect to combine this immunodominant peptide with our broadly reactive helper peptides that are currently being tested in a phase I trial, to create a tru
'/>"/>

SOURCE TapImmune Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. New Report Details NCPA Efforts to Drive Greater Medication Adherence
2. ADVENTRX Announces Details Of The Phase 3 Study Of ANX-188
3. CoLucid Pharmaceuticals Details Phase 3 Development Strategy for Lasmiditan to Address Major Unmet Needs in Acute Migraine Therapy
4. Young Innovations, Inc. Provides 2nd Quarter Conference Call Details
5. CryoLife Announces Release Date and Teleconference Call Details for 2012 Second Quarter Financial Results
6. Physician Details Problems with Medicare Approval Process for Power Wheelchairs
7. New Study Details Foreign Efforts To Lure Biopharmaceutical Companies
8. Robbins Arroyo LLP Announces the Filing of a Securities Fraud Class Action Lawsuit Against Hemispherx Biopharma, Inc.
9. MAQUET Cardiovascular Announces U.S. Food and Drug Administration Panel Votes To Reclassify Intra-Aortic Balloon Pumps To A Class II Designation In Certain Indications
10. Barrack, Rodos & Bacine Files Class Action Lawsuit Against St. Jude Medical, Inc.
11. Thomson Reuters Empowers Drug Development and Clinical Professionals to Develop Better, Faster Clinical Trials with Best-in-Class Intelligence Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... 2014 A study on the ... added to Transparency Market Research,s database of market reports. ... Size, Share & Forecast (2011 - 2017)", the report ... 3.9 billion in 2011, would observe growth at a ... of the report), and end-up valuing US$ 4.8 billion ...
(Date:9/22/2014)... , Sept. 22, 2014  Continua and ... in healthcare technology, media and telecommunications,  have formed ... China and promote international ... BHG announced this new partnership during the global ... Washington, DC , while also ...
(Date:9/22/2014)... Md. , Sept. 22, 2014  Neuralstem, Inc. (NYSE ... MD, site investigator at Emory University, presented long-term follow ... human neural stem cells in the treatment of amyotrophic ... The presentation, which occurred at the Annual Symposium on ... Canada , on Friday, and was not open ...
Breaking Medicine Technology:Global Magnetic Resonance Imaging (MRI) Market Worth US $4.8 Billion by 2017: Transparency Market Research 2Global Magnetic Resonance Imaging (MRI) Market Worth US $4.8 Billion by 2017: Transparency Market Research 3Global Magnetic Resonance Imaging (MRI) Market Worth US $4.8 Billion by 2017: Transparency Market Research 4Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 2Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 3Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 4Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4
... Calif., Oct. 21, 2011 Thoratec Corporation (Nasdaq: ... therapies to save, support and restore failing hearts, today announced ... quarter of fiscal 2011 on Tuesday, November 1. ... financial results and operating activities, open to all interested parties, ...
... Mass., Oct. 21, 2011 NxStage Medical, ... of innovative dialysis products, today announced it ranked 141 ... fastest growing technology, media, telecommunications, life sciences and clean ... percentage of fiscal year revenue growth during the period ...
Cached Medicine Technology:Thoratec Schedules Third Quarter Conference Call, Webcast 2NxStage® Ranked Number 141 on the Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 2NxStage® Ranked Number 141 on the Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 3
(Date:9/22/2014)... Recent two-generation approaches to reducing poverty that help ... from researchers, advocates, and foundations. By combining education ... move to jobs that offer a path out ... for children, these programs aim to improve the ... a new report from the National Center for ...
(Date:9/22/2014)... The Workgroup for Electronic ... authority on the use of health IT to ... from its recent industry survey on the use ... electronic transactions adopted under the Health Insurance Portability ... from August 20 to September 5, which included ...
(Date:9/22/2014)... HealthDay Reporter MONDAY, Sept. ... wonders: What can I do to help ensure a healthy ... prescribed may play a role in reducing the risk of ... researchers found that mothers of children with autism were significantly ... pregnancy than those whose children seem to be developing normally. ...
(Date:9/22/2014)... Severe weather can occur with little warning, so it’s ... of National Preparedness Month, Amica Insurance is offering the ... unexpected:, , Build an emergency supply kit. It ... gallon of water per person per day for at least 72 ... includes pets so your family knows what to do and where ...
(Date:9/22/2014)... 22, 2014 The struggles that lie ... (LEP) patients has been well-documented—reportedly, language barriers between doctors ... to the emergency room and an increased likelihood for ... At Sanford Health, the largest medical facility in the ... LEP population necessitated the need for Video Remote ...
Breaking Medicine News(10 mins):Health News:A two-generation lens: Current state policies fail to support families with young children 2Health News:WEDI Announces Survey Results from Unique Health Plan Identifier (HPID) Industry Poll 2Health News:WEDI Announces Survey Results from Unique Health Plan Identifier (HPID) Industry Poll 3Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 2Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 3Health News:Amica Shares Tips for National Preparedness Month 2Health News:Healthcare Cost Savings Case Study:Stratus Video Interpreting Assists Sanford Health System in Accommodating Increasing LEP Population,Saves a Predicted $100,000 Per Year 2Health News:Healthcare Cost Savings Case Study:Stratus Video Interpreting Assists Sanford Health System in Accommodating Increasing LEP Population,Saves a Predicted $100,000 Per Year 3Health News:Healthcare Cost Savings Case Study:Stratus Video Interpreting Assists Sanford Health System in Accommodating Increasing LEP Population,Saves a Predicted $100,000 Per Year 4
... the computers are sought in order to develop a vaccine ... have the ability to perform difficult task and can work ... good at handling long and complex problems with ease. In ... a cure against bird flu. Mostly computers that can crunches ...
... associated with spinal tumors has been developed by a ... vertebrae is a common feature in 5 to 10 ... ,Wade Wong, D.O.F.A.C.R, UCSD professor of radiology, ... spinal tumors from 28 patients before repairing the spine ...
... although prostate cancer was extremely dangerous, men over 75, ... radical prostatectomy or radiation does help to ... elders is often affected because of resulting urinary incontinence ... M. Hoffman, an associate professor of medicine at the ...
... is believed to play a key role in the development ... that the revelation could be of immensely helpful for the ... an enzyme called telomerase is believed to contribute to the ... tumors. A lack of detailed information regarding its structure had ...
... laureate hopes to manufacture plentiful anti-flu drugs at a cheaper ... work out the method while relaxing at home on a ... and given it to World Health Organization to prevent any ... for the production cycle is a compound extracted from the ...
... officials of the NHS Grampian said that people were offered ... NHS health board said so defending their decision to house ... ,A spokeswoman for NHS Grampian said a doctor always ... for a patient to stay outwith the city's Royal Infirmary. ...
Cached Medicine News:Health News:Novel Technique To Revolutionize Treatment Of Spinal Tumors 2
... 3000 Plus Sectioning System provides a versatile ... or plant tissues. The 3000 employs ... without freezing or embedding. The creation ... destruction of enzyme activities, and other deleterious ...
... standard with a square vice mounting ... utilized for mounting specimens and placing ... The blocks are annodized black for ... reused. They are shipped three ...
Injector blades come ten to an injector and allow for the easy replacement of Vibratome cutting blades....
... includes everything from the care package ... Spare Fluorescent Bulb, additional Vibratome Feather ... and a Specimen Tray. ... 1/2" speciment mounts, replacement rotating mounts, ...
Medicine Products: