Navigation Links
Depression and Cognitive Disorders: at the Onset of Alzheimer's Disease

Depression and Cognitive Disorders: at the Onset of Alzheimer's Disease

Advanced Search Search

  1. Send a release
  2. Member sign in
  3. Become a member
  4. For journalists
  5. Global sites
PR Newswire: news distribution, targeting and monitoring
  1. Products & Services
  2. Knowledge Center
  3. Browse News Releases
  4. Contact PR Newswire
Health Care & Hospitals, Pharmaceuticals, New Products & Services, Clinical Trials & Medical Discoveries Click to view news release full screen  

Depression and Cognitive Disorders: at the Onset of Alzheimer's Disease


BASEL, Switzerland, Oct 4 /PRNewswire-FirstCall/ - Neuro-Biotech Corporation (PINKSHEET: MRES) (OTCQB: MRES) introduces a Neuro-biomarker which is linked to a series of Neuro-Bio tests. This will permit to understand the science behind them and how they each will contribute to a progressive clinical investigation involving the input and output of the brain.  All Neuro-biomarkers are expressed with a numeric value to ensure that doctors can rapidly see and comprehend how the results will confirm their diagnoses, therefore allowing them to successfully find and manage the best therapeutical approach.

Alzheimer's Disease (AD), a chronic disorder that slowly and progressively destroys neurons, was first described by Alois Alzheimer in 1906. Even though, the aetiology (the study of the cause) of AD is still unknown, several possibilities such as extracellular β-amyloid and hyperphosphorylated tau proteins hypothesises were investigated but the results were not conclusive (Zekanowski et al., 2004).  However, new theories related to electrolytes like calcium, magnesium, zinc and their relationships are being studied to find how the neurodegenerative process gradually begins (Bojarski et al., 2008).

The relationship between the dopaminergic and cholinergic mechanisms was first studied in regards to postural tremor in monkeys and circling movements in cats (Poirier et al., 1974) in response to drugs. The measurement of specific enzymes activities as well as the turnover rate of catecholamines and indolamines, allow the understanding of the contribution of ChAT (choline acetyl-transferase) and GAD synthesising enzyme to the Krebs cycle (the metabolic pathway within the cells) in affecting the release of ATP by the mitochondria, responsible for the level of cellular energy that influence the internal and external cellular homeostasis. In this respect, brain specific enzyme activity of ChAT, tyrosine hydroxylase, tryptophan hydroxylase, DOPA /5HTP decarboxylase and DBH and their biochemical parameters were respectively studied in cats and rats using several drugs and electrolytes such as aluminium, calcium, copper, iron etc (Bouchard et al., 1981; Dontigny & Roberge, 1984; Nadeau & Roberge, 1988; Blais & Roberge, 1991; Fortin & Roberge, 1992; Nucloseph et al., 1996).

To further understand the neurobiology of AD through chemical events, memory mechanisms were studied in cats using various learning tests such as "go-no-go discrimination," "delayed response," and "visual discrimination." In normal cats, an increase in the specific ChAT activity corresponds to an increased turnover rate of the neurotransmitters (Kitsikis et al., 1973,1981., Boisvert, 1978; Everett & Roberge, 1981; Vachon et al., 1983).  On the other hand, the inducibility of ChAT (choline acetyl-transferase) was studied in order to understand how neuronutrition with appropriate nutrients will favour the increased acetylcholine release. It was successfully demonstrated by an increase in ChAT activity with nutrients such as cobalamine, phosphatidylethanolamine and neutral amino acids.

Experiments and studies done on several species demonstrated that the brain noradrenergic and cholinergic pathways in the mesolimbic system are in a close relationship with the HPAS Axis: cognitive disorders & depression taming emotions. In this respect, early diagnosis at the age of 35, will allow to distinguish between "senility", "senile dementia" related to age, "vascular dementia" and the malignant disease called "AD"and will later significantly contribute to clarify the real cause of death.  As AD is a multiparametrical and evolutive disease, an appropriate follow-up could be developed based on a neurobio-psycho-socio-environmental approach, to improve the patient's quality of life.

In summary, the ChAT enzyme activity could be induced and following several learning tests, an increase in specific ChAT enzyme activity was observed as well as a significant change in the turnover rate of serotonin and noradrenaline in the structures belonging to the mesolimbic system. With this close relationship with the HPAS Axis (cognitive disorders & depression taming emotions, this clinical feature should be clinically evaluated upon reaching 35 years of age (WHO, 2000). Contact:
Neuro-Biotech Corp.
Dr Claude Poulin
41 61 500 05 16

SOURCE Neuro-Biotech Corp.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. New Study Supports Efficacy of Vagus Nerve Stimulation for Treatment-Resistant Depression
2. New Data Suggest Cymbalta(R) Reduced Pain in Fibromyalgia Patients With and Without Depression
3. SPRI Clinical Trials Now Enrolling Patients for Study of New Treatment for Depression
4. Lilly Receives NCQA Design Certification for Depression Care Management Program
5. Penn Research Shows Transcranial Magnetic Stimulation Effective in Treating Major Depression
6. Treating Depression Prolongs Life for Older People with Diabetes
7. Forest Laboratories, Inc. Announces Positive Results of LEXAPRO(R) Phase III Study in Adolescents With Major Depression
8. Kaiser Permanente - Group Health Study Shows Depression Worsens HIV Treatment
9. AstraZeneca Submits sNDAs for SEROQUEL XR(TM) for the Treatment of Bipolar Mania and Bipolar Depression
10. BrainCells Inc. Initiates Phase 2 Clinical Trial with BCI-540 for Depression with Anxiety
11. Study Demonstrates Lexapro(R) Significantly Improves Depression Symptoms in Adolescents
Post Your Comments:
(Date:6/26/2016)... Australia,s successful biotechnology scientists, Dr Graham ... Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). Noxopharm is seeking ... ASX. Noxopharm is a clinic-ready company with its first ... study later this year. NOX66 ... cancer patients - the ability of cancers to become resistant to ...
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) announced ... Act of 1976, as amended ("HSR"), with respect to ... CPXX ) expired effective June 24, 2016, ... previously announced on May 31, 2016, Jazz Pharmaceuticals and ... Jazz Pharmaceuticals has commenced a tender offer for all ...
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
Breaking Medicine News(10 mins):