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Depression Therapeutics - Pipeline Assessment and Market Forecasts to 2018

imary Efficacy Endpoint 43

Table 20: SNRIs Approved for Depression 44

Table 21: MADRS Total Score Mean Change from Baseline to Endpoint 47

Table 22: Depression Therapeutics, Phase III Pipeline, 2011 50

Table 23: Depression Therapeutics, Phase II Pipeline, 2011 50

Table 24: Depression Therapeutics, Phase I Pipeline, 2011 51

Table 25: Depression Therapeutics, Pre-clinical Pipeline, 2011 52

Table 26: Depression Therapeutics – Most Promising Drugs Under Clinical Development, 2011 57

Table 27: Lu AA21004 Efficacy Measure 57

Table 28: Treatment-Related Adverse Events 58

Table 29: AGO178, Active Comparator Study 59

Table 30: Depression Therapeutics, Clinical Trials by Country, 2011 61

Table 31: Depression Therapeutics, Clinical Trials by Phase, 2011 62

Table 32: Depression Therapeutics, Clinical Trials by Status, 2011 63

Table 33: Depression Therapeutics, Overall Sponsors, 2011 64

Table 34: Depression Therapeutics, Prominent Sponsors, 2011 65

Table 35: Depression Therapeutics, Top Companies Participating in Therapeutics Clinical Trials, 2011 66

Table 36: Lundbeck A/S – Depression, Pipeline Products, 2011 70

Table 37: Novartis, Depression Pipeline, 2011 72

Table 38: AstraZeneca PLC, Depression Pipeline, 2011 73

Table 39: Eli Lilly and Company, Depression Pipeline, 2011 74

Table 40: Targacept Inc., Depression Pipeline, 2011 76

Table 41: Depression Therapeutics, Global, Deals, 2009-2011 77

List of Figures

Figure 1: DSM-IV Diagnostic Criteria for Depression 8

Figure 2: Total Estimated Cost of Brain Disorders in Europe by Disease Area 10

Figure 3: Economic Burden Associated with Depression 10

Figure 4: Relationship Between Major Depression and Cardiovascular Disease 12

Figure 5: Serotonergic Systems in Alteration of Depression 13

Figure 6: Alterations of Norad

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