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Depression Study Published on BCM-95 Curcumin
Date:7/11/2013

on on its own at the same level as the drug, and even better results when combined with the drug. This may be meaningful for the health of millions of people."

The study included 3 arms of 20 volunteers diagnosed with major depressive disorder receiving either BCM-95 Curcumin, 500 mg capsules twice daily; fluoxetine 20 mg daily, or the combination of BCM-95 Curcumin twice daily with fluoxetine once daily. Results were assessed using the clinically validated Hamilton Rating Scale for Depression (HAM-D17 scale). This scale is used to rate the severity of  depression by evaluating mood, feelings of guilt, suicide ideation, insomnia, agitation or motor retardation, anxiety, weight loss, and other somatic symptoms.

The authors reported that curcumin was well tolerated by all the patients. The proportion of responders as measured by the HAM-D17 scale was higher in the combination group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups, however, these data were not statistically significant (P = 0.58) from one another. Therefore, the BCM-95 Curcumin worked as well as the prescription drug fluoxetine in terms of changes in the HAM-D17 score from baseline to six weeks of treatment. This study provides the first human clinical indication that curcumin may be used as an effective and safe treatment for patients with MDD without concurrent suicidal ideation or other psychotic disorders.

The study was made available online in July in advance of publication in the journal Phytotherapy Research. Phytotherapy Research is a monthly, international journal for the publication of original research papers on medicinal plant research. Key areas of interest are pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. The journal is indexed in the National Institutes of Health (NIH) National Library of Medicine's (NLM) electronic database, Medline,
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SOURCE Ajay Goel, Ph.D.
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