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Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases
Date:7/7/2009

cancer, for which denosumab is administered twice yearly subcutaneously at a 60 mg dose. The Prolia(TM) trade name is only for these indications and may not apply for other indications of denosumab.

(1) Capanna R, Coia LR, Coleman R. et al. eds. Textbook of Bone Metastases. Hoboken, NJ: Edition: John Wiley and Sons; 2005:105.

(2) Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002 Aug;2(8):584-93.

(3) Schulman K and Kohles J. Cancer. 2007;109:2334-2342

(4) GVD/Barber ISPOR 2008 Poster; Schulman 2007; Delea et al. 2006

    Amgen, Thousand Oaks
    Lisa Rooney, 805-447-6437 (media)
    Arvind Sood, 805-447-1060 (investors)

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