Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic H...( - Data Presented at American Urol...),Health

- Data Presented at American Urological Association Annual Meeting -

SEATTLE and ORLANDO, Fla., May 21 /PRNewswire-FirstCall/ -- Researchers from Dendreon Corporation (Nasdaq: DNDN) today presented preclinical data demonstrating the potential of D-3263, Dendreon's orally bioavailable small molecule, which targets Trp-p8 (a transmembrane cation channel protein also known as Trp-M8), to treat benign prostatic hyperplasia (BPH).

The abstract (#2041), "Preclinical Validation of the Trp-p8 Ion Channel as a Target for Benign Prostatic Hyperplasia," is being presented at the American Urological Association's 2008 Annual Meeting in Orlando, Fla., on Wednesday, May 21, 2008, at 2:50 PM ET.

In a preclinical study, BPH was induced through subcutaneous injection of testosterone propionate (TP). One week prior to initiation of testosterone, either D-3263 or finasteride, a current treatment for BPH, was administered daily for four weeks. Following treatment, blood was sampled, prostates were collected and weighed, and cross sections were stained with Trp-p8 antibody.

"We are encouraged by these data which demonstrate the potential for D-3263, our lead small molecule targeting Trp-p8, to serve as a drug candidate for the potential treatment of BPH -- a disease affecting a substantial number of men between 50 and 60 years of age," said David Urdal, chief scientific officer of Dendreon. "We had previously shown that D-3263 specifically kills cancer cells that express Trp-p8, and we look forward to filing an investigational new drug application later this year to initiate a study examining D-3263 in advanced cancer, including prostate cancer."

Results showed that the BPH-induced prostates expressed significantly higher le
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