Navigation Links
Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia
Date:4/28/2009

o. While finasteride is a known inhibitor of 5-alpha reductase, the enzyme that converts testosterone to DHT, D-3263 is not an inhibitor of this enzyme suggesting that the two agents may act by different means to affect androgen metabolism and prostate hyperplasia.

"BPH is a condition that affects a significant number of men, and based on the preclinical data announced today demonstrating the drug's ability to reduce the size and weight of the prostate, we believe that D-3263 may be able to impact this disease," said David Urdal, Ph.D., chief scientific officer of Dendreon. "We are also exploring the role of TRPM8 in cancer, given that TRPM8 is upregulated on cancer cells. A Phase 1 clinical trial to evaluate this molecule against multiple types of solid tumors has been recently initiated."

About TRPM8

TRPM8 (also known as TRPP8) was identified through Dendreon's in-house discovery efforts. It is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP proteins. In normal human tissues, TRPM8 is expressed predominantly in the prostate, a gland in the male reproductive system. It is over-expressed in prostate hyperplasia and multiple types of cancer including prostate cancer, breast cancer, colon cancer and lung cancer. In recent years, it has emerged that TRP channels play a diverse and key role in cell biology and in pathology. Dendreon has synthesized small molecule agonists including D3263 that activate the TRPM8 ion channel and induce cell death.

About Dendreon

Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development and commercialization of novel therapeutics. The Company applies its expertise in antigen identification, engineering and cell processing to produce active cellular immunotherapy pr
'/>"/>

SOURCE Dendreon Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer
2. Dendreon to Hold a Conference Call Tomorrow at 9:00 AM ET to Discuss Final Results of Phase 3 PROVENGE IMPACT Trial
3. Dendreon Presents Integrated Analysis of Clinical Data from NEUVENGE Trials at Chemotherapy Foundation Symposium
4. Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial
5. Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial
6. Dendreon Expects Interim Data Analysis for Phase 3 PROVENGE IMPACT Trial in October
7. Dendreon Initiates Phase 2 Trial of PROVENGE in Patients With Localized Prostate Cancer Prior to Surgery
8. Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic Hyperplasia
9. Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival
10. Dendreon Completes Target Enrollment of 500 Patients in Phase 3 IMPACT Study of Provenge(R) For Advanced Prostate Cancer
11. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... , December 15, 2014 Investor-Edge has ... ZGNX ), Eli Lilly and Company (NYSE: ... (NYSE: SNY ), and Novartis AG (NYSE: ... be accessed at: http://investor-edge.com/register . On Friday, ... 1.16%, the Dow Jones Industrial Average lost 1.79%, to finish ...
(Date:12/15/2014)... Dec. 15, 2014  Stephen Squires, CEO and founder ... Materials Corp (OTCQB:QTMM), will be speaking at the ... (RCQM) on December 16th, 2014. The RCQM launch continues ... in attracting top faculty and students and by inviting ... research. "We have a long association ...
(Date:12/15/2014)...  The Government of Ghana has endorsed ... (GBF) and Terumo BCT to respond to the emerging Ebola crisis ... long-term health system capacity to the citizens of Ghana ... Ebola Readiness and Resilience Initiative (GERRI) is a multi-agency effort designed ... the possible arrival of the Ebola epidemic , Provide new ...
Breaking Medicine Technology:Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 2Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 3Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 4Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 5Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 2Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 4Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 5Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 6
... 14, 2010 VIVUS, Inc. (Nasdaq: VVUS ) ... effort to secure regulatory approval for QNEXA® in the U.S., ... (FDA) designed to address items in the FDA,s Complete Response ... announced that the Endocrine and Metabolic Division of the FDA ...
... Science, Inc. (OTC Bulletin Board: CBIS ) a ... to announce it has signed a lease for a new ... Colorado. The 6,600 sq. ft. core facility at 2422 S. ... offices, administrative personnel, as well as the Lab Division core ...
Cached Medicine Technology:VIVUS Submits Briefing Document to FDA, Announces Follow-up Meeting to Discuss QNEXA® 2VIVUS Submits Briefing Document to FDA, Announces Follow-up Meeting to Discuss QNEXA® 3Cannabis Science Signs Lease for New 6,600 sq. ft. Corporate Headquarters and Laboratory Facility 2Cannabis Science Signs Lease for New 6,600 sq. ft. Corporate Headquarters and Laboratory Facility 3
(Date:12/17/2014)... Nwe is the co-author of a new weight loss book ... the Ace Medical Weight Loss Center in Rock Hill, SC. ... the industry of weight loss, and how several fad diets ... television shows, however, she says the topic of obesity is ... basic laughs, which she believes impacts whether Americans view it ...
(Date:12/17/2014)... December 17, 2014 In its comprehensive ... and its Argus Claim Review division have recently identified ... most common ways savings are achieved on behalf of ... millions of dollars in savings to Argus each year, ... , As explained by Tom Doney, Cypress president and ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... one worrisome phenomenon is when an illness that originated in ... as zoonosis -- is not uncommon and keeps researchers on ... disease might make inroads into the human population. A ... the culprits in this case were guinea pigs. More specifically, ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... improve overall health, but a growing body of evidence shows ... review finds. In fact, the benefits were similar to ... researcher Paula Chu, a doctoral candidate at Harvard University,s Health ... trials, found that people randomly assigned to take yoga classes ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), ... a new study providing evidence on the impact of ... children. , Sufficient enough evidence already exists showing a ... juice drinks, with the onset of tooth decay. One ... listed as 100% fruit juice, meaning it is completely ...
Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 3Health News:Yoga May Cut Heart Disease Risk Factors 2Health News:Yoga May Cut Heart Disease Risk Factors 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2
... that one in five men in their 40s has ... year and that young black men are more likely than ... published in the September 15, 2008 issue of CANCER ... valuable information as experts discuss possible changes to prostate cancer ...
... chemical might lead to drug treatments for humans , , SUNDAY, ... of mice resistant to diet-induced obesity. , The findings ... in people. They also shed light on the brain circuitry ... energy (i.e., food) an animal takes in and how quickly ...
... leading provider of enterprise portal connectivity solutions, announced ... Health Centre and Dr. Jay Wallin of Mount ... the monthly educational series reThinking eHealth. The session, ... physicians share ways their facilities have improved provider ...
... second shot now recommended , , FRIDAY, Aug. 8 (HealthDay News) ... United States in 1995, medical experts hoped it would be ... of a child,s first birthday giving lifelong immunity. , Now, ... protection from a single immunization fades over time, and that ...
... of Miley Cyrus and,the Jonas Brothers will have more ... artists take the stage with other performers at Disney,s,Concert ... programs at City of Hope. It will be held ... Tickets for the concert will,be available Saturday, August 16 ...
... TORONTO, Aug. 8 /PRNewswire/ - IntelliPharmaCeutics is pleased ... this press release to,the Company, include IntelliPharmaCeutics Ltd. ... has been very active with drug development work ... in Toronto, Canada. We,presently have 34 staff employed ...
Cached Medicine News:Health News:1 in 5 young men has had recent prostate cancer test 2Health News:Scientists Create Mice Resistant to Obesity 2Health News:Scientists Create Mice Resistant to Obesity 3Health News:Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction 2Health News:Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction 3Health News:Give the Providers What They Want: Two Physicians Share Ways Their Facilities Have Improved Provider Satisfaction 4Health News:Chickenpox Protection: Get That Booster 2Health News:Chickenpox Protection: Get That Booster 3Health News:The Walt Disney Company Is Presenting Miley Cyrus, Jonas Brothers and Demi Lovato in a Special Concert to Benefit City of Hope on September 14 2Health News:The Walt Disney Company Is Presenting Miley Cyrus, Jonas Brothers and Demi Lovato in a Special Concert to Benefit City of Hope on September 14 3Health News:IntelliPharmaCeutics Provides Update on Activities 2Health News:IntelliPharmaCeutics Provides Update on Activities 3Health News:IntelliPharmaCeutics Provides Update on Activities 4
...
...
Rhoton Curettes, titanium, length 191 mm, straight....
Sundt Slim-Line Temporary Vessel Clips used for temporary vascular occlusion during intracranial surgical procedures. Non-magnetic, MP35N, MRI compatible, gold color. Bayonet....
Medicine Products: