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Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia
Date:4/28/2009

o. While finasteride is a known inhibitor of 5-alpha reductase, the enzyme that converts testosterone to DHT, D-3263 is not an inhibitor of this enzyme suggesting that the two agents may act by different means to affect androgen metabolism and prostate hyperplasia.

"BPH is a condition that affects a significant number of men, and based on the preclinical data announced today demonstrating the drug's ability to reduce the size and weight of the prostate, we believe that D-3263 may be able to impact this disease," said David Urdal, Ph.D., chief scientific officer of Dendreon. "We are also exploring the role of TRPM8 in cancer, given that TRPM8 is upregulated on cancer cells. A Phase 1 clinical trial to evaluate this molecule against multiple types of solid tumors has been recently initiated."

About TRPM8

TRPM8 (also known as TRPP8) was identified through Dendreon's in-house discovery efforts. It is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP proteins. In normal human tissues, TRPM8 is expressed predominantly in the prostate, a gland in the male reproductive system. It is over-expressed in prostate hyperplasia and multiple types of cancer including prostate cancer, breast cancer, colon cancer and lung cancer. In recent years, it has emerged that TRP channels play a diverse and key role in cell biology and in pathology. Dendreon has synthesized small molecule agonists including D3263 that activate the TRPM8 ion channel and induce cell death.

About Dendreon

Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development and commercialization of novel therapeutics. The Company applies its expertise in antigen identification, engineering and cell processing to produce active cellular immunotherapy pr
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SOURCE Dendreon Corporation
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