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Dendreon Announces Presentation of PROVENGE Data at the 25th International Society for Biological Therapy of Cancer Annual Meeting
Date:10/1/2010

SEATTLE and WASHINGTON, Oct. 1 /PRNewswire/ -- Dendreon Corporation (Nasdaq: DNDN) today announced the following PROVENGE® (sipuleucel-T) data presentations taking place at the 25th International Society for Biological Therapy of Cancer (iSBTc) annual meeting in Washington, D.C.

  • "Sipulecel-T Immune Parameters and Correlation with Overall Survival." Session 2 of the Symposium on Immuno-Oncology Biomarkers, 2010 and Beyond: Correlation of Immunity to Clinical Response and Potency Assays from 10:00 a.m. to 12:00 p.m. EDT on Thursday, September 30, 2010.
  • "Progress in the Active Immunotherapy of Prostate Cancer: Sipuleucel-T, an Autologous Cellular Immunotherapy." Plenary Session: Dendritic Cells and Cancer from 9:15 to 9:45 a.m. EDT on Saturday, October 2, 2010.
  • "Characterization of Antigen Specific T-cell Activation and Cytokine Expression Induced by Sipuleucel-T." Poster presentation from 7:00 – 7:45 p.m. EDT on Saturday, October 2, 2010.

Data presented at the iSBTc annual meeting include data from the pivotal Phase 3 IMPACT study in which PROVENGE demonstrated a statistically significant improvement in overall survival compared to control in men with asymptomatic or minimally symptomatic metastatic castrate resistant prostate cancer (mCRPC).  

"The analyses from the pivotal Phase 3 IMPACT trial examining a subset of patients showed an enhanced immune response in patients treated with PROVENGE," said Mark Frohlich, M.D., senior vice president of clinical affairs and chief medical officer of Dendreon. "These findings provide further understanding of PROVENGE's proposed mechanism of action designed to stimulate a patient's immune system to identify and attack prostate cancer cells."

PROVENGE is the first product in a new therapeutic class known as autologous cellular immunotherapi
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SOURCE Dendreon Corporation
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2. Dendreon Completes Target Enrollment of 500 Patients in Phase 3 IMPACT Study of Provenge(R) For Advanced Prostate Cancer
3. Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival
4. Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic Hyperplasia
5. Dendreon Initiates Phase 2 Trial of PROVENGE in Patients With Localized Prostate Cancer Prior to Surgery
6. Dendreon Expects Interim Data Analysis for Phase 3 PROVENGE IMPACT Trial in October
7. Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial
8. Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial
9. Dendreon Presents Integrated Analysis of Clinical Data from NEUVENGE Trials at Chemotherapy Foundation Symposium
10. Dendreon to Hold a Conference Call Tomorrow at 9:00 AM ET to Discuss Final Results of Phase 3 PROVENGE IMPACT Trial
11. Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer
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