Navigation Links
Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial
Date:10/6/2008

- Conference Call Scheduled for 9:00 AM ET Today -

SEATTLE, Oct. 6 /PRNewswire-FirstCall/ -- Dendreon Corporation (Nasdaq: DNDN) announced today that it has completed the planned interim analysis of the Phase 3, randomized, double-blind, placebo-controlled IMPACT (IMmunotherapy for Prostate AdenoCarcinoma Treatment, also known as D9902B) clinical trial designed to assess the safety and efficacy of the investigational active cellular immunotherapy PROVENGE(R) (sipuleucel-T) in men with metastatic androgen-independent prostate cancer. While Dendreon remains blinded to the data, the independent data monitoring committee (IDMC) reported to Dendreon a 20 percent reduction in the risk of death in the PROVENGE arm relative to placebo (Hazard Ratio= 0.80; 95% Confidence Interval [0.610-1.051]). The IDMC observed no safety concerns and recommended that the study continue to its final analysis.

"The treatment effect we have observed in this interim analysis is consistent with that observed in the integrated analysis of our previous Phase 3 trials in this patient population when analyzed at a similar 24-month follow-up time," said Mitchell H. Gold, M.D., president and chief executive officer of Dendreon. "Given the delayed treatment effect we have seen in previous studies, we are pleased to see evidence suggesting a prolongation of survival in the PROVENGE arm at the time of the interim analysis, as well as a favorable safety profile."

At the final analysis, which is anticipated in the middle of 2009, if the study demonstrates approximately a 22 percent reduction in the risk of death, based on 304 events, the company would expect the study to meet its primary endpoint of overall survival.

"We look forward to the final results next year and the opportunity to make PROVENGE available to the many men with advanced prostate cancer who currently have few appealing treatment options," said Dr. Gold.

The IMPACT trial is a randomized,
'/>"/>

SOURCE Dendreon Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial
2. Dendreon Expects Interim Data Analysis for Phase 3 PROVENGE IMPACT Trial in October
3. Dendreon Initiates Phase 2 Trial of PROVENGE in Patients With Localized Prostate Cancer Prior to Surgery
4. Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic Hyperplasia
5. Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival
6. Dendreon Completes Target Enrollment of 500 Patients in Phase 3 IMPACT Study of Provenge(R) For Advanced Prostate Cancer
7. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
8. The Childrens Hospital of Philadelphia Announces New Regional Participant in The National Childrens Study
9. Lilly Announces Initiation of Second Global Phase III Trial of Investigational Alzheimers Disease Compound
10. Resurgent Health and Medical Announces That Childrens Hospitals and Clinics of Minnesota has Ordered 25 CleanTech Automated Handwashing Systems
11. Bioheart Announces 35 Leading U.S. Heart Failure Centers Engaged in Phase II/III Marvel Trial of Myogenic Cells for Treating Advanced Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... ORLANDO, Fla. , July 28, 2014 /PRNewswire/ ... "Company"), a biopharmaceutical company focused on the development, ... that it has filed definitive proxy materials with ... its 2014 Annual Meeting of Shareholders to be ... a.m., East Standard Time. The record date for ...
(Date:7/28/2014)... 2014 ResMed (NYSE: RMD ), ... cura dei disturbi respiratori del sonno (SDB) e altre ... in Germania contro il produttore Taiwanese di dispositivi medicali, ... apparecchiature da indossare in testa, che violano i brevetti, ... La sentenza della Corte Regionale Distrettuale di ...
(Date:7/28/2014)... (NYSE: RMD ), an innovator and pioneer ... and other chronic respiratory conditions, has won a permanent ... medical device manufacturer APEX Medical Corp. (APEX), prohibiting sales ... 220 masks.  The judgment was entered by the Regional ... appealable, and applies throughout Germany.  The ...
Breaking Medicine Technology:TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 3ResMed riceve un'ingiunzione permanente contro APEX in Germania, continua a far valere i propri diritti per i brevetti in Europa 2ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2
(Date:7/29/2014)... WA (PRWEB) July 29, 2014 Award-winning inventor ... , a flatulence neutralizer specifically designed to absorb embarrassing odors ... charcoal that can easily be stored in a desk drawer. ... use the PoofPad, users will simply sit on the pad ... gas at the office and then BAM, someone appears out ...
(Date:7/29/2014)... 2014 Riverdale Urgent Care is making ... Through their presence at local events, partnerships and other ... than just a medical service for the Riverdale neighborhood. ... in support of Riverdale RiverFest and South Riverdale Street ... features local musicians and entertainers, arts and crafts, boat ...
(Date:7/29/2014)... July 29, 2014 Lean and Lovely, an ... for women who want to wear a bikini in the ... Stevenson, prompting an investigative review. , “Our Lean and ... for women at all fitness levels. Neither your age nor ... unfit your body is at the beginning, you will achieve ...
(Date:7/29/2014)... Current Back2Basics long-term drug rehab resident Jon B. ... his first six months of sobriety. , This was ... foot, once on the other– which was how he became ... ago and was prescribed drugs that I didn’t take properly.” ... home who’d recently completed the program. The six-month long residential ...
(Date:7/29/2014)... 29, 2014 PeopleKeys today announced that ... teach students how to train and certify others in ... Behavioral Consultant Trainer , will be taught by PeopleKeys ... Training John Schindell as a live Tele-course over the ... The Certified Behavioral Consultant Trainer course will use a ...
Breaking Medicine News(10 mins):Health News:Award-Winning Inventor Michael Croix Launches an Indiegogo Campaign for PoofPad 2Health News:Award-Winning Inventor Michael Croix Launches an Indiegogo Campaign for PoofPad 3Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 2Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 3Health News:Lean and Lovely: Review Examining Neghar Fonooni’s Program Released 2Health News:Back2Basics Sober Living Resident Overcomes Obstacle in Early Sobriety 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 3
... contaminated fish are enormous and especially children and women ... much// and which fish they eat says-"The Madison Declaration ... of the international science journal Ambio. ,Developed ... Global Pollutant last August in Madison, Wis., the declaration ...
... of different biomolecules (DNA, proteins, etc.) has been created ... technology makes possible the development of low-cost clinical bedside ... customizable particles, could also be used for disease monitoring, ... are thinner than the width of a human hair, ...
... variety of autoimmune diseases that are aggravated when one ... cell, malfunctions. In humans, one cause of this malfunction ... the immune cells’ ability to function. In a new ... the National Academy of Sciences, researchers at the University ...
... bulb turning on in the head. Scientists have reversed this ... light shines on it. ,The unexpected result, reported ... heads. ,"This is daydreaming at this point, but ... implanted light to stop seizures," says senior author Steven Mennerick, ...
... mothers' beliefs about diarrhea can lead to inappropriate treatment ... University undergraduate in Africa concluded the research. ... records – revealed that a “large proportion” of the ... a rudimentary understanding of how best to either prevent ...
... American Academy of Neurology finds that epidural steroid injections ... for lower back pain// that radiates down a leg, ... ,To develop the guideline, the authors analyzed scientific studies ... epidural steroid injections may provide some short-term pain relief ...
Cached Medicine News:Health News:Methylmercury in Marine Fish Pose Health Risks to Pregnant Women and Elderly Men 2Health News:Methylmercury in Marine Fish Pose Health Risks to Pregnant Women and Elderly Men 3Health News:A New Inexpensive Technology for Multiplexed Detection 2Health News:A New Inexpensive Technology for Multiplexed Detection 3Health News:Researchers Discover New Molecular Path to Fight Autoimmune Diseases 2Health News:Light-activated Compound May Be of Help for Epileptics in Future 2Health News:Light-activated Compound May Be of Help for Epileptics in Future 3Health News:Mothers in African Study Undereducated on Diarrhea 2Health News:Mothers in African Study Undereducated on Diarrhea 3
Kleinert-Kutz Single Skin Hook, Large...
Medium....
Goldman single hook....
These products are supplied non-sterile and must be sterilized before use. For insertion through the smokevac and nezhat-dorsey trumpet valve in conjunction with the universal instrument insert adapt...
Medicine Products: