Navigation Links
DelMar Pharmaceuticals to Present Interim Clinical Data on VAL-083 in Refractory Glioblastoma at Society for Neuro-Oncology (SNO) Annual Meeting
Date:11/15/2012

armacokinetics and anti-tumor activity of VAL-083 in patients with histologically confirmed initial diagnosis of primary WHO Grade IV malignant glioma (GBM), now recurrent.  Patients with prior low-grade glioma or anaplastic glioma are eligible, if histologic assessment demonstrates transformation to GBM.  Patients with secondary brain tumors due to CNS metastases are also eligible for the study.

GBM patients must have been previously treated for GBM with surgery and/or radiation, if appropriate, and must have failed both Bevacizumab (Avastin®) and temozolomide (Temodar®), unless either or both are contra-indicated. 

Response to therapy and disease progression will be evaluated by MRI prior to each treatment cycle.  An initial phase of the study will involve dose escalation cohorts until a maximum tolerated dose (MTD) is established in the context of modern care.  Once the modernized dosing regimen has been established, additional patients will be enrolled at the MTD (or other selected optimum dosing regimen).

DelMar Pharma is conducting the study under the direction of Dr. Howard Burris at the Sarah Cannon Research Institute in Nashville, Tennessee with a second center in Sarasota, Florida. 

Please refer to clinicaltrials.gov identifier NCT01478178 for further details on this clinical trial.

About DelMar Pharma
Del Mar Pharmaceuticals was founded in 2010 to develop and commercialize proven cancer therapies in new orphan drug indications where patients are failing modern targeted or biologic treatments. The Company's lead asset, VAL-083, is currently undergoing clinical trials in the United States as a potential treatment for refractory glioblastoma multiforme (GBM), the most common and aggressive form of brain cancer.  VAL-083 benefits from extensive clinical research sponsored by the US National Cancer Institute, and is currently approved for the treatment o
'/>"/>

SOURCE Del Mar Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Auspex Pharmaceuticals Receives U.S. Patent on Novel JAK Inhibitor SD-900
2. Access Pharmaceuticals To Host Third Quarter Investor Call on Wednesday, November 28th
3. Ground Zero Pharmaceuticals, Inc. (GZP) Announces Enhanced Biosimilars and Personalized Medicine Initiatives for its Clients
4. Cardioxyl Pharmaceuticals Raises $28 Million In Series B Financing Led By OrbiMed Advisors
5. Savara Pharmaceuticals AeroVanc Granted U.S. Orphan Drug Designation for the Treatment of MRSA Lung Infection in Cystic Fibrosis Patients
6. Edison Pharmaceuticals Announces Initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
7. Frost & Sullivan: Lack of Proper Price Regulation for Pharmaceuticals
8. Jazz Pharmaceuticals Announces Participation In Three Investor Conferences In November
9. Achillion Pharmaceuticals, Inc. Hosts the HCV Connection Media Briefing at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
10. Omthera Pharmaceuticals Presents Data From Analysis Of EVOLVE Trial Showing That Epanova Lowers ApoC-III, A Key Predictor of Cardiovascular Risk
11. Jazz Pharmaceuticals Announces Third Quarter 2012 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... Calif. , Jan. 14, 2014 The Brandeis Medical Center, ... Angeles a premier and affordable laser tattoo removal experience ... Dr. Brandeis, focus is in providing high quality cosmetic services with ... patients. " Southern California has seen ...
(Date:1/14/2014)... Emergency Critical Care, a LifeCentre partner practice, located at 165 Fort ... first in Loudoun County to receive a ... M. Barnes , Medical Director, is a well-seasoned veterinarian of more ... , are avid scuba divers. "As altitude skiers and hikers, we ...
(Date:1/14/2014)... Oligomerix, Inc. , a privately held company pioneering the ... and related neurodegenerative disorders, announced today the relocation of ... as of January 15, 2014 and expanded lease ... College. Oligomerix, which is focused on the ...
Breaking Medicine Technology:Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... WOONSOCKET, R.I., Feb. 14, 2012  CVS Caremark (NYSE: ... impact study of CVS Caremark,s contribution to the ... company,s national headquarters is located.  According to the ... for CVS Caremark, the company,s Rhode Island operations ...
... Feb. 14, 2012 Watson Pharmaceuticals, Inc. (NYSE: ... $1.5 billion for the fourth quarter ended December 31, 2011, ... a non-GAAP basis, net income for the fourth quarter 2011 ... 93 percent, compared to $116.5 million or $0.93 per share ...
Cached Medicine Technology:Report: CVS Caremark Contributes Billions to Rhode Island Economy 2Report: CVS Caremark Contributes Billions to Rhode Island Economy 3Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 2Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 3Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 4Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 5Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 6Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 7Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 8Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 9Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 10Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 11Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 12Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 13Watson Full Year 2011 Net Revenue Increases 29% to $4.58 Billion; 14
(Date:4/18/2014)... School of Medicine researchers have been awarded two-year grants ... Nordisk announced this month. Of the 110 initial submissions ... Science Forum Program, only four projects were funded, three ... are Jonathan Powell, M.D., Ph.D.; G. William Wong, Ph.D.; ... a professor of oncology, will use his $500,000 proof ...
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/18/2014)... A discovery by Northwestern Medicine scientists could lead to ... scarring in people with scleroderma. , Fibrosis, or ... tightening of the skin and lungs can lead to ... The concept for new therapeutic options centers on findings ... Medicine-Rheumatology, who identified the role that a specific protein ...
(Date:4/17/2014)... Scientists have identified the first genetic variant specifically ... sub-type accounting for around 10-15 per cent of ... study of the breast cancer sub-type, called invasive ... genetic causes of this particular kind of breast ... The research, published today (Thursday) in the journal ...
(Date:4/17/2014)... According to a study published today in PLOS ... world where malaria is common can mount an immune ... them to avoid repeated bouts of high fever and ... in their bloodstream. The findings may help researchers develop ... by the malaria parasite. , Each year, approximately 200 ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:New clues on tissue scarring in scleroderma 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2
... Sayre Area School District in Bradford County today became ... H1N1 influenza vaccine to its student population, the Department ... reminded all parents that immunizations play a significant role ... disproportionately affecting school-aged children, with almost two-thirds of all ...
... into diseases and treatments, experts say , FRIDAY, Oct. ... detailed map of the human epigenome, gaining greater understanding ... past, we,ve been limited to viewing small snippets of ... Genomic Analysis Laboratory at the Salk Institute for Biological ...
... RATON, Fla., Oct. 16 Although stem cells sounds ... for quite some time. In today,s advanced medical ... orthopedic conditions including osteoarthritis of the hip knee and ... rotator cuff tears, and various back conditions including ...
... physicians will be using electronic prescribing and other health ... million federal grant secured by U.S. Senator Patrick Leahy. ... Technology Leaders, Inc. (VITL), will provide incentives to physicians ... In June, Vermont was cited by Surescripts as the ...
... DALLAS, Oct. 16 John Killian, Chairman of Parent ... the United States focused on finding a cure for Duchenne ... that the 5th Annual Sam,s Family Fun Day ... 10am to 2pm on Flagpole Hill at White Rock Lake. ...
... The Avon Foundation for Women is marking Breast ... celebrations, and tributes. Throughout October, the Foundation will call ... save lives, and raise millions of dollars for the ... the sale of fundraising products, Avon Walks for Breast ...
Cached Medicine News:Health News:Pennsylvania Department of Health Announces First School to Begin Administering H1N1 Vaccine to Students 2Health News:Scientists Provide First Map of Complete Human Epigenome 2Health News:Stem Cell and PRP Therapy for Orthopedic Conditions 2Health News:Stem Cell and PRP Therapy for Orthopedic Conditions 3Health News:Leahy Secures Funds to Support Adoption of Electronic Prescribing in Vermont 2Health News:Leahy Secures Funds to Support Adoption of Electronic Prescribing in Vermont 3Health News:Leahy Secures Funds to Support Adoption of Electronic Prescribing in Vermont 4Health News:Leahy Secures Funds to Support Adoption of Electronic Prescribing in Vermont 5Health News:Sam's Day Celebrates 5 Year Anniversary; Local Family Event Will Benefit Largest U.S. Non-Profit Fighting Duchenne Muscular Dystrophy 2Health News:Sam's Day Celebrates 5 Year Anniversary; Local Family Event Will Benefit Largest U.S. Non-Profit Fighting Duchenne Muscular Dystrophy 3Health News:Photos: Avon Foundation for Women Celebrates Breast Cancer Awareness Month 2Health News:Photos: Avon Foundation for Women Celebrates Breast Cancer Awareness Month 3
... CardioDirect12-S is the stress testing system from ... turn-key system including treadmill or bicycle ergometer, ... BP option. It uses the same CardioDirect ... resting ECG. ,The system is ...
... monitor, store and measure data during the performance ... organize the amount of information detected during the ... and printout of an extremely flexible final report. ... small portable ECG recorder (ECT 12 no ...
... Marco's CP-690E Automatic Chart Projector makes refracting ... you program up to 33 charts in any ... examination in a darkened room simply by pressing ... to the next chart. In addition, the CP-690E's ...
... Ultimate in Stability. ... stabilizer features superior arm ... in the clamp/turret mechanism. ... features the ultimate flexibility ...
Medicine Products: