Navigation Links
DelMar Pharmaceuticals to Present Interim Clinical Data on VAL-083 in Refractory Glioblastoma at Society for Neuro-Oncology (SNO) Annual Meeting
Date:11/15/2012

ption," added Mr. Bacha.

About VAL-083
VAL-083 represents a 'first in class' small-molecule chemotherapeutic. VAL-083 has been assessed in multiple NCI-sponsored clinical studies in various cancers including lung, brain, cervical, ovarian tumors and leukemia.  Published pre-clinical and clinical data suggest that VAL-083 may be active against a range of tumor types.  VAL-083 is approved as a cancer chemotherapeutic in China for the treatment of chronic myelogenous leukemia and lung cancer

Based on published research, the mechanism of action of VAL-083 is understood to be a bi-functional alkylating agent; however, the functional groups associated with alkylating events has been shown to differ from other alkylating agents used in the treatment of GBM.

VAL-083 has previously demonstrated activity in cyclophosphamide, BCNU and phenylanine mustard resistant cell lines and no evidence of cross-resistance has been encountered in published clinical studies.  Based on the presumed alkylating functionality of VAL-083, published literature suggests that DNA repair mechanisms associated with Temodar and nitrosourea resistance, such as 06-methylguanine methyltransferace (MGMT), may not confer resistance to VAL-083. 

VAL-083 readily crosses the blood brain barrier where it maintains a long half-life in comparison to the plasma.  Published preclinical and clinical research demonstrates that VAL-083 is selective for brain tumor tissue.

VAL-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.  In general, tumor regression was achieved following therapy in greater than 40% of patients treated and stabilization was achieved in an additional 20% - 30%.  In published clinical studies, VAL-083 has previously been shown to have a statistically significant impact on median survival in high grade gliomas when combined with radiation vs. radiation
'/>"/>

SOURCE Del Mar Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Auspex Pharmaceuticals Receives U.S. Patent on Novel JAK Inhibitor SD-900
2. Access Pharmaceuticals To Host Third Quarter Investor Call on Wednesday, November 28th
3. Ground Zero Pharmaceuticals, Inc. (GZP) Announces Enhanced Biosimilars and Personalized Medicine Initiatives for its Clients
4. Cardioxyl Pharmaceuticals Raises $28 Million In Series B Financing Led By OrbiMed Advisors
5. Savara Pharmaceuticals AeroVanc Granted U.S. Orphan Drug Designation for the Treatment of MRSA Lung Infection in Cystic Fibrosis Patients
6. Edison Pharmaceuticals Announces Initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
7. Frost & Sullivan: Lack of Proper Price Regulation for Pharmaceuticals
8. Jazz Pharmaceuticals Announces Participation In Three Investor Conferences In November
9. Achillion Pharmaceuticals, Inc. Hosts the HCV Connection Media Briefing at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
10. Omthera Pharmaceuticals Presents Data From Analysis Of EVOLVE Trial Showing That Epanova Lowers ApoC-III, A Key Predictor of Cardiovascular Risk
11. Jazz Pharmaceuticals Announces Third Quarter 2012 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... und SAN DIEGO , ... Company, Ltd. (nachstehend Daiichi Sankyo) (TSE: 4568) ... ) gaben heute gemeinsam eine definitive Fusionsvereinbarung ... Aktienkapital von Ambit Biosciences für 15 US-Dollar ... und anschließenden Zusammenschluss mit einem Tochterunternehmen von ...
(Date:9/29/2014)... , September 29, 2014 The ... 21.1 billion by 2018, recording a CAGR of 8.8% ... Delivery Devices Market - Global Industry Analysis, Size, Share, ... Research, a U.S.-based market intelligence company. The ... benefit from an increasing occurrence of cardiovascular diseases, diabetic ...
(Date:9/29/2014)... PRINCETON N.J. , Sept. 29, 2014 /PRNewswire/ ... agents for medical imaging, has received a Drug ... Drug Administration for its assistance in preventing or ... being recognized for its efforts related to the ... the new drug application, submitting several post-approval supplements ...
Breaking Medicine Technology:Daiichi Sankyo wird Ambit Biosciences übernehmen 2Daiichi Sankyo wird Ambit Biosciences übernehmen 3Daiichi Sankyo wird Ambit Biosciences übernehmen 4Daiichi Sankyo wird Ambit Biosciences übernehmen 5Daiichi Sankyo wird Ambit Biosciences übernehmen 6Daiichi Sankyo wird Ambit Biosciences übernehmen 7Daiichi Sankyo wird Ambit Biosciences übernehmen 8Global Implantable Drug Delivery Devices Market to Grow at 8.8% CAGR to US$ 21.1 billion by 2018: Transparency Market Research 2Global Implantable Drug Delivery Devices Market to Grow at 8.8% CAGR to US$ 21.1 billion by 2018: Transparency Market Research 3Global Implantable Drug Delivery Devices Market to Grow at 8.8% CAGR to US$ 21.1 billion by 2018: Transparency Market Research 4Guerbet Receives FDA's Drug Shortage Assistance Award: Recognized for contributions to address a shortage of Ethiodol (ethiodized oil) injection 2
... RESEARCH TRIANGLE PARK, N.C., Oct. 16 Liquidia,Technologies ... founder,and University of North Carolina-Chapel Hill professor, Joseph ... DeSimone will discuss drug delivery,applications of the PRINT(TM) ... (Logo: http://www.newscom.com/cgi-bin/prnh/20060614/CLW002LOGO ), -- ...
... went to see Dr. Peter Hersey, a medical oncologist ... was told he only had three,to six months to ... one,of the most difficult to treat forms of cancer. ... previously treated,area of his face and nothing was helping ...
Cached Medicine Technology:Targeted Nanoparticles Offer Promise in the Battle Against Cancer 2Recipient of Melanoma Drug in Development Celebrates Two Cancer-Free Years 2
(Date:9/30/2014)... 2014 From October 12-15, MMS, ... the 2014 SHSMD Connections Annual Conference in San Diego, ... & Market Development (SHSMD) is proud to host the ... and communications, and strategic planning professionals in San Diego ... , The conference is a four-day event designed ...
(Date:9/30/2014)... IN (PRWEB) September 30, 2014 ... Ron Receveur encourages all persons who have received dental ... in a recent blog post. , The post, which ... with dental implants that if they don’t brush and ... same way people lose their natural teeth: the bone ...
(Date:9/30/2014)... “Biology and botany are having an ... it’s about naming rights.” , In Homeostasis: ... the Bryan William Brickner Blog, the focus is ... Health (PubMed). The post highlights five cannabinoid system ... aging with THC, the wake-inducing effects of CBD, ...
(Date:9/30/2014)... September 30, 2014 Named a ... East Longmeadow facility has officially announced that they ... that combines advanced medical technology with supportive, ... one of the only non-hospital options available in ... The primary focus of this Ventilator Program ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 American Medical ... a collaborative agreement to raise awareness about Alzheimer’s disease ... IDs for people with these brain disorders. , American ... generated by AFA to the foundation to support its ... their families. The ID bracelets and necklaces can be ...
Breaking Medicine News(10 mins):Health News:MMS, Inc. (Medical Marketing Service) to Attend the 2014 SHSMD Connections Annual Conference in October 2Health News:All on Four Dental Implants Dentist Writes Blog on Preventing Gum Disease 2Health News:All on Four Dental Implants Dentist Writes Blog on Preventing Gum Disease 3Health News:Homeostasis: Publius’ Sleep Political Cannabinoid Science ~ New on the Bryan William Brickner Blog 2Health News:Wingate Healthcare Announces New Ventilator Care Program at East Longmeadow Facility 2Health News:Wingate Healthcare Announces New Ventilator Care Program at East Longmeadow Facility 3Health News:American Medical ID and Alzheimer’s Foundation of America Team up to Increase Awareness about Alzheimer’s Disease and Related Dementias 2Health News:American Medical ID and Alzheimer’s Foundation of America Team up to Increase Awareness about Alzheimer’s Disease and Related Dementias 3
... study by a Swedish researcher on the effects of the ... likely to occur when they have their period. The// researcher ... fluctuations causing the levels of relaxin (a hormone which relaxes ... studied for the research and it was seen that women ...
... from fatty foods that we eat. A certain amount// of cholesterol ... keep the body healthy but a high level can lead to ... a build up of small fatty lumps developing on the inside ... are at greater risk if we smoke, have high blood pressure ...
... a press release the Ministry of Health has indicated the current ... on Dengue// the Ministry has confirmed reports of 9453 cases ... upto 12 .30 hrs. ,In Delhi and NCR - ... of 2872 cases and 59 deaths have been reported from Delhi, ...
... access to a high-profile detainee at Guantanamo Bay, Cuba, ... secrets" whose revelation could "cause extremely grave damage", the ... at secret CIA prisons must not be allowed to ... even to their lawyers, the Post reported.,A lawyer at ...
... medical problems and surgeries in space before astronauts start moving ... a person develops a problem say, in Mars? He or ... time simply because it takes over three years to reach ... little difference in the dose of general anesthesia needed to ...
... industry which has been simmering in the trans-fat controversy for ... their sticky ally- the hydrogenated// vegetable oils! This is perhaps ... & Spencer, Asda, Sainsbury’s and Tesco have already communicated their ... British Medical Journal has urged the Government to bring in ...
Cached Medicine News:Health News:Researchers explore medicine in space 2Health News:Researchers explore medicine in space 3
Full Handle Laseredge Crescent Blade Knife, angled double bevel. Blade tip dimension: 12.7 mm x 2.0 mm x 3.8 mm....
Full Handle Laseredge Crescent Blade Knife, angled bevel up. Blade tip dimension: 12.7 mm x 2.0 mm x 3.8 mm....
Full Handle Laseredge Stab Blade Knife, 45 blade. Blade tip dimension: 8.9 mm x 1.9 mm x 1.9 mm....
Full Handle Laseredge Stab Blade Knife, 15 blade. Blade tip dimension: 3 mm x 1.0 mm x 3.0 mm....
Medicine Products: