Navigation Links
DelMar Pharmaceuticals Presents Interim Phase 1/2 Clinical Data for VAL-083 in Glioblastoma at Society for Neuro-Oncology Annual Meeting
Date:11/22/2013

ion of mandated safety observation period with Cohort 4 (10mg/m2). 

- Pharmacokinetic analysis demonstrates a dose-dependent plasma exposure. 

The poster entitled "Phase I/II study of VAL-083 in patients with recurrent malignant glioma or progressive-secondary brain tumor," will be presented today from 7 p.m. to 9 p.m.

In August, DelMar received notice of allowance from the U.S. Food and Drug Administration (FDA) that will enable the company to alter the dose-escalation of its ongoing Phase 1/2 of VAL-083 in refractory glioblastoma multiforme (GBM) patients.  After an extensive safety review of patients treated to date, the FDA allowed the revised dosing regimen detailed in the following chart, which enables the trial to reach higher doses and complete the dose-escalation portion of the clinical trial more quickly.  The revised dosing scheme also permits dosing above 30mg/m2 if VAL-083 is safe and well tolerated at that dose.  Dose Escalation
Scheme (mg/m2)Patients
Treated Status OriginalRevised1.51.53

Completed – No DLT3.03.04*

Completed – No DLT5.05.010*

Completed – No DLT10.010.03

No DLT**15.020.020.03

(planned)

Enrollment scheduled Dec

201325.030.030.03

(planned)

To be initiated subject to

no DLT in 20mg/m2 dose*Cohorts 2 and 3 were expanded to allow for patient demand

and to gather additional data on CNS metastases patients.

 

** Observation period for final patient in this cohort ongoing"From previous controlled clinical trials sponsored by the U.S. National Cancer Institute (NCI), we have seen promising safety and efficacy data for VAL-083 in glioblastoma," said Mr. Bacha.  "With our accelerated dose escalation plan compared to the NCI's dosing sche
'/>"/>

SOURCE DelMar Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. DelMar Pharmaceuticals to Present Interim Clinical Data for VAL-083 in Glioblastoma at Society of Neuro-Oncology
2. DelMar Pharmaceuticals Gives Quarterly Shareholder Update
3. DelMar Pharmaceuticals Presents Data Supporting VAL-083 as a Potential Treatment for Three Chemotherapy Resistant Cancers
4. DelMar Pharma reviews glioblastoma clinical trials and new therapeutic development on CEOLIVE.TV
5. DelMar Pharmaceuticals and Guangxi Wuzhou Pharmaceuticals Establish Clinical Advisory Board in China
6. DelMar Pharmaceuticals To Present At The 15th Annual Rodman & Renshaw Global Investment Conference
7. DelMar Pharmaceuticals, Inc. Investor Presentation Now Available for On-demand Viewing at RetailInvestorConferences.com
8. DelMar Pharmaceuticals Presents Additional Clinical Data from Ongoing Brain Cancer Study at ASCO
9. DelMar Pharmaceuticals, Inc. to Webcast, Live, at RetailInvestorConferences.com June 6th
10. DelMar Pharmaceuticals to Present Clinical Trials Data for VAL-083 Brain Cancer Trial at the American Society of Clinical Oncology (ASCO) Annual Meeting
11. DelMar Pharmaceuticals, Inc. Provides Corporate Update for the Quarter Ended March 31, 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 23, 2014  Medical Science Liaisons play a large ... between the medical device industry and key stakeholders, the ... coming years as the device industry relies on them ... research by benchmarking firm, Best Practices, LLC, one area ... edge is by harnessing new technology to enable education. ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) ... Blood Glucose Market" report to their offering. ... market insight focuses on the developments in the self-monitoring ... . Reimbursement analysis and the effects of competitive ... than 73 SMBG meters have been performed, based on ...
(Date:12/22/2014)... Cyberonics, Inc. (NASDAQ: CYBX ), a ... of epilepsy, today announced it will participate in the 33 ... 14, 2015, in San Francisco . ... Officer, will speak at 11:00 AM Pacific Time.  A live ... on the Investor Relations link on the Cyberonics home page ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... Verathon Inc. is pleased to announce the launch ... www.verathon.com . Developed with help from physicians, nurses ... offers an array of innovative features and detailed ... get the product information they need.  The site ...
... Radiologic (vRad), a technology-enabled national radiology practice, has again ... market segment by independent research and consulting firm KLAS. ... interviews conducted by KLAS and is published in the ... Software & Professional Services report. In ...
Cached Medicine Technology:Verathon® Maker of BladderScan® and GlideScope® Medical Instruments Launches New Website 2Virtual Radiologic Ranked #1 for Teleradiology Services for Third Consecutive Year 2
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a comprehensive ... and marketing of a series of induction heating equipment. ... series of induction brazing equipments . , According ... brazing refers to the joining of two or ... The manager says that there are fundamental differences in ...
(Date:12/25/2014)... The click strand woven bamboo flooring ... Today, the business announces a click strand woven ... 30, 2015. , Click strand woven bamboo flooring ... a well-known brand in the bamboo industry. It ... reliable bamboo flooring supplier. , “We are happy ...
(Date:12/25/2014)... “Every three months the trends for evening ... dress will be one of the hottest styles in the ... Today, the company releases 26 A-line sweetheart evening dresses, and ... , “We are trying our best to help a ... designs. Along with affordable prices, we provide discounted delivery costs ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Recently, ... discounts on all its wedding dresses. BellasDress has chosen ... more for gift choices for the holiday season. ... can pick suitable wedding gowns here at discount prices. ... shopping experience at its website. , “All ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2
... ... & Me, - to find the most inspiring young users of FM technology. , ... Murten, Switzerland (PRWEB) February 11, 2009 -- Phonak, leading ... Me , - in order to track down the most inspiring young users of FM technology. ...
... CHARLOTTE, N.C. , Feb. 8 Medical teams from ... Haiti . Through an agreement with the Department of the Navy, CHS ... providing care to victims of the January earthquake. , The first ... will remain in Haiti for two weeks.  Navy medical officials ...
... (PSA) screening in the U.S. than in a European ... a new brief communication published online February 8 in ... To compare the PSA screening performance in a ... M. Wever, MSc, Department of Public Health, Erasmus Medical ...
... the experimental drug dimebon (latrepirdine) in people with Huntington,s disease ... is the conclusion of a study published today in the ... the first clinical trial that has focused on what is ... of Rochester Medical Center neurologist Karl Kieburtz, M.D., the lead ...
... the regimen is followed, , MONDAY, Feb. 8 (HealthDay News) ... oil, whole grains, fish and fruit -- may protect aging ... finds , Other studies have already found that such diets ... death. , The latest study was led by Dr. ...
... ENGLEWOOD, Colo. , Feb. 8 /PRNewswire/ -- ... a new, colorful dinosaur-themed indoor playground at MCGHealth Children,s Medical ... playground is certainly a place for fun, it has also ... needs of our patients," reports Barbara Meeks , Vice ...
Cached Medicine News:Health News:Phonak Asks Young FM Users to Tell Their Stories on YouTube 2Health News:Carolinas HealthCare System Volunteers to Join Navy Rescue Mission in Haiti 2Health News:Carolinas HealthCare System Volunteers to Join Navy Rescue Mission in Haiti 3Health News:Lower detection of prostate cancer with PSA screening in US than in a European randomized trial 2Health News:Drug shows promise for Huntington's disease 2Health News:Mediterranean Diet May Help Keep You Smarter 2Health News:Active Play Aids Recovery, Makes Hospital Stay Easier 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: