Navigation Links
DelMar Pharmaceuticals Announces Completion Of $10.5 Million Oversubscribed Offering And Appointment Of Investor Relations Consultant
Date:3/7/2013

083 represents a 'first in class' small-molecule chemotherapeutic. VAL-083 has been assessed in multiple NCI-sponsored clinical studies in various cancers including lung, brain, cervical, ovarian tumors and leukemia.  Published pre-clinical and clinical data suggest that VAL-083 may be active against a range of tumor types.  VAL-083 is approved as a cancer chemotherapeutic in China for the treatment of chronic myelogenous leukemia and lung cancer

Based on published research, the mechanism of action of VAL-083 is understood to be a bi-functional alkylating agent; however, the functional groups associated with alkylating events has been shown to differ from other alkylating agents used in the treatment of GBM.

VAL-083 has previously demonstrated activity in cyclophosphamide, BCNU and phenylanine mustard resistant cell lines and no evidence of cross-resistance has been encountered in published clinical studies.  Based on the presumed alkylating functionality of VAL-083, published literature suggests that DNA repair mechanisms associated with Temodar and nitrosourea resistance, such as 06-methylguanine methyltransferace (MGMT), may not confer resistance to VAL-083. 

VAL-083 readily crosses the blood brain barrier where it maintains a long half-life in comparison to the plasma.  Published preclinical and clinical research demonstrates that VAL-083 is selective for brain tumor tissue.

VAL-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.  In general, tumor regression was achieved following therapy in greater than 40% of patients treated and stabilization was achieved in an additional 20% - 30%.  In published clinical studies, VAL-083 has previously been shown to have a statistically significant impact on median survival in high grade gliomas when combined with radiation vs. radiation alone. 

The mai
'/>"/>

SOURCE DelMar Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. DelMar Pharmaceuticals Announces Appointment of John K. Bell to Board of Directors
2. DelMar Pharmaceuticals Announces $1.6 Million Closing in Private Placement
3. DelMar Pharmaceuticals Announces $1.0 Million Third Closing in Private Placement
4. DelMar Pharmaceuticals to Present Interim Clinical Data on VAL-083 in Refractory Glioblastoma at Society for Neuro-Oncology (SNO) Annual Meeting
5. AcelRx Pharmaceuticals to Hold Fourth Quarter 2012 Financial Results Conference Call and Webcast on March 12, 2013
6. Cadence Pharmaceuticals Reports Fourth Quarter and Full Year 2012 Financial Results
7. Inovio Pharmaceuticals Prices $15.1 Million Offering of Common Stock and Warrants
8. Receptos Determines Novel GPCR Structure, Achieves Key Milestone in Collaboration with Ono Pharmaceuticals
9. AVANIR PHARMACEUTICALS ANNOUNCES RESEARCH COLLABORATION WITH DEPARTMENT OF VETERANS AFFAIRS FOR SCREENING PSEUDOBULBAR AFFECT (PBA) SYMPTOMS IN VETERANS WITH TRAUMATIC BRAIN INJURY
10. Cylene Pharmaceuticals and TetraGene Enter Agreement for Quarfloxin and Anticancer Quadruplex Technologies
11. Isis Pharmaceuticals to Present at the Barclays Global Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... and BOSTON , May 24, 2013 ... company, is pleased to announce that it has engaged Mr ... Company,s business development capabilities in Japan and ... years of experience in business development, licensing and alliance management in ... Pharma ( Japan ), Nippon Roche and Tanabe Seiyaku ...
(Date:5/23/2013)... PARÍS, 24 de mayo de 2013  Volcano ... desarrollador y fabricante de herramientas de precisión para ... tratamiento de la enfermedad vascular periférica y coronaria, ... ( Ad enosine V asodilator I ... durante la sesión de ensayo clínico hot line ...
(Date:5/23/2013)... , May 23, 2013  Haemonetics Corporation (NYSE: ... , CFO & EVP-Business Development, will present at The Deutsche ... Boston, MA on May 29, 2013 ... ) The public may access Mr. Lindop,s ... About Haemonetics Haemonetics (NYSE: HAE ...
Breaking Medicine Technology:Heptares Augments Business Development Capabilities in Japan and Other Asian Territories 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6
(Date:5/24/2013)... Range Kleen Mfg. strives to “TCOTC.” Our number one ... President's desk to the Shipping Dock.” We hold high in ... passion while creating excellence and quality being results oriented. It ... the right thing and what better way to help with ... , Throughout the year Range Kleen donates to numerous local ...
(Date:5/24/2013)... 2013 This week is National EMS ... efforts to provide the best emergency care and to ... week is also to educate the public that all ... Citizens are the first link, and a very important ... CPR after a cardiac arrest can triple a victim’s ...
(Date:5/24/2013)... hospitalized for heart failure appear to have better odds ... the morning, a new study finds. Death rates ... patients admitted in January, on Fridays and overnight, according ... findings Saturday in Portugal at the annual meeting of ... Cardiology. "The fact that patients admitted right ...
(Date:5/24/2013)... 2013 KC and Monica Craichy, Founders of ... FreeRide836. Their oldest sons, Kyle and Austin Craichy, will be ... and several professional kiteboarders. , KC Craichy said he is ... miraculously come together such that virtually everyone who planned to ... 20 kite boarders will meet at Matheson Hammock Park and ...
(Date:5/24/2013)... May 24 (HealthDay News) -- New research suggests ... among people with insomnia. Every additional hour ... 72 percent drop in the likelihood of moderate ... from the University of Pennsylvania. "We ... between sleep duration and suicide risk," study author, ...
Breaking Medicine News(10 mins):Health News:Range Kleen Partners with Berndes in Red Cross Promotion: Taking Care of Oklahoma 2Health News:Acadian Medics Reunite with Miracle Baby 2Health News:Monday Best Time for Hospitalization With Heart Failure, Study Says 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:Sleep Duration Linked to Suicidal Thoughts in People With Insomnia 2
... ... In addition to its archiving solutions for email, file and ... solution to complete its unified archiving solutions for all enterprise messaging ... ensure a seamless integration of all file types, and that the ...
... ... United States have become less satisfied with their health insurers, according to ... Hit hard by the recession, employers of all sizes are taking a ... from it. They are looking to their health plan providers for ...
... ... and five medical office buildings on 11 acres in Mesquite, Texas. , ... Mesquite, Texas (PRWEB) January 19, 2010 -- A ... via sealed bid auction on Friday, February 5. The property will be available ...
... ... Dr.Gulani releases his slogan for eye surgeons worldwide and hindsight could soon be 20/10. He believes ... such vision goals for most of their patients. , ... (PRWEB) January 19, 2010 -- 20/20 vision has been the hallmark of perfect vision. ...
... ... a dental tourism facilitator specializing only in dentistry that is dedicated to helping patients ... ... After years of expensive visits to the dentist, Jeff Apton emerged from retirement to ...
... , LOS ANGELES , ... three regional Hospital Associations, and the National Health Foundation, announced ... million dollar effort to improve the quality and consistency of ... launch of Patient Safety First... a California Partnership ...
Cached Medicine News:Health News:MessageSolution Unveils Enterprise Class Lotus Quickr Archiving Solution at IBM's Lotusphere 2010 2Health News:MessageSolution Unveils Enterprise Class Lotus Quickr Archiving Solution at IBM's Lotusphere 2010 3Health News:MessageSolution Unveils Enterprise Class Lotus Quickr Archiving Solution at IBM's Lotusphere 2010 4Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 2Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 3Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 4Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 5Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 6Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 7Health News:Former Hospital and Office Buildings in Mesquite, Texas, up for Sealed Bid Auction from Sperry Van Ness Accelerated Marketing 2Health News:20/10 Vision in the Year 2010: Is "HD Vision" Beyond 20/20 a Reality? 2Health News:20/10 Vision in the Year 2010: Is "HD Vision" Beyond 20/20 a Reality? 3Health News:Snatched from the Jaws of Retirement: Spiraling Treatment Costs Push Senior To Start Pan American Dental Tours 2Health News:Snatched from the Jaws of Retirement: Spiraling Treatment Costs Push Senior To Start Pan American Dental Tours 3Health News:Anthem Blue Cross Partners With California Regional Hospital Associations and The National Health Foundation To Launch an Historic Three-Year Statewide Patient Safety Collaborative 2Health News:Anthem Blue Cross Partners With California Regional Hospital Associations and The National Health Foundation To Launch an Historic Three-Year Statewide Patient Safety Collaborative 3Health News:Anthem Blue Cross Partners With California Regional Hospital Associations and The National Health Foundation To Launch an Historic Three-Year Statewide Patient Safety Collaborative 4Health News:Anthem Blue Cross Partners With California Regional Hospital Associations and The National Health Foundation To Launch an Historic Three-Year Statewide Patient Safety Collaborative 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: