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Del Mar CEO Delivers Keynote Address at International Drug Discovery Science and Technology Conference
Date:11/8/2012

VANCOUVER, British Columbia, Nov. 8, 2012 /PRNewswire/ -- Del Mar Pharmaceuticals (BC) Ltd. (DelMar) today announced that Mr. Jeffrey Bacha, the Company's President & CEO, delivered the keynote address entitled VAL-083 a Novel Chemotherapeutic Agent Developed in China for CML and Lung Cancer Shows Potential to Surpass Standard of Care in Glioblastoma Multiforme at the 2012 International Drug Discovery Science and Technology Conference in Nanjing, China.

In his address, Mr. Bacha highlighted DelMar's ongoing Phase I/II clinical trial with VAL-083 as a potential new therapy for patients suffering from glioblastoma multiforme (GBM), the most common and aggressive form of brain cancer.

The trial, which is being conducted under an investigational new drug application (IND), in the United States is designed to evaluate the safety, tolerability and anti-tumor activity of VAL-083 in GBM patients who have failed front line therapy with Temodar™ and second-line therapy with Avastin™.  According to published data, approximately half of patients diagnosed with GBM will fail both front and second line therapy.  Currently, there are no approved treatments for these patients.

"DelMar has developed new data to re-position the dosing regimen for GBM in the context of modern care," stated Mr. Bacha in his address.  "We believe that this approach will provide benefit to patients who currently have very limited treatment options."

VAL-083, known as "DAG for Injection" in China, represents a first-in-class bi-functional alkylating agent.  The drug benefits from prior extensive clinical research sponsored by the United States National Cancer Institute (NCI), and is approved as a cancer chemotherapeutic in China for the treatment of chronic myelogenous leukemia (CML) and lung cancer.  Previous pre-clinical and clinical studies sponsored by the NCI suggest that VAL-083 may have activity against a range of tumor
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SOURCE Del Mar Pharmaceuticals
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