Navigation Links
Degarelix (FIRMAGON(R)) vs Leuprolide (Lupron Depot(R)) in Patients With Advanced Prostate Cancer: Further Analysis From a Phase III Pivotal Trial
Date:12/4/2009

"time to event" was defined as the number of days from first dosing to the first occurrence of PSA recurrence or death. PSA recurrences were analyzed by baseline PSA level.

PSA recurrence was 12.9% for leuprolide 7.5 mg/month patients compared to 7.7% with the approved degarelix 240/80 regimen. The probability of completing the study without experiencing PSA recurrence by day 364 was 91.1% (95% CI: 85.9-94.5) for degarelix and 85.9% (95% CI: 79.9-90.2) for leuprolide 7.5 mg/mo. The probability of completing the study without dying by day 364 was 97.4% (95% CI: 93.8-98.9) for degarelix versus 95.1% (95% CI: 90.7-97.4) for leuprolide 7.5 mg/mo. In patients with baseline PSA >20 ng/mL, risk of PSA recurrence was lower for patients receiving degarelix compared with leuprolide (p=0.04). The risk of PSA recurrence was comparable in patients with baseline PSA >50 ng/mL (p=0.10).

At Day 3 of treatment, the degarelix group achieved a 90 percent decrease in median testosterone levels compared with the leuprolide group, which experienced a 65 percent increase in median testosterone levels. Degarelix was as effective as leuprolide in suppressing testosterone levels from Day 28 to the end of the study (Day 364), with 97.2% of the degarelix patients maintaining medical castrate levels compared with 96.4% for leuprolide.

About FIRMAGON

FIRMAGON is an injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced prostate cancer. As a receptor antagonist, FIRMAGON reversibly binds to the GnRH receptors in the pituitary gland, immediately suppressing the secretion of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and subsequently, testosterone levels.(1-4)

FIRMAGON also reduces levels of prostate-specific antigen (PSA). Unlike luteinizing hormone-releasing hormone (LHRH) agonists, such as leup
'/>"/>

SOURCE Ferring Pharmaceuticals Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy
2. BSGI Makes Significant Impact on Detection of Breast Cancer in Patients with Negative Mammographic Findings
3. Sanofi-aventis: Multaq(R) Approved in the European Union for Patients With Atrial Fibrillation
4. Unindicated CT Series Result in Unnecessary Radiation Exposure for Patients
5. Philips Responds to Industry Concerns With Focus on Radiation Dose Management Products Designed for Clinicians and Patients
6. Caldolor(R) (Ibuprofen) Injection Demonstrates Significant Fever Reduction in Hospitalized Burn Patients
7. Proteon Initiates Second Phase 1/2 Clinical Study of PRT-201 in Hemodialysis Patients
8. Echo Therapeutics Announces Positive Results of a Clinical Study Testing Symphony(TM) tCGM System in Patients with Type 1 and Type 2 Diabetes
9. Quark Reports Progress of siRNA Clinical Programs; 300 Patients Dosed With Quark Pharmaceuticals siRNA Drugs In Multiple Fully Enrolled Clinical Trials
10. New Updates to AHA/ACC/SCAI Clinical Guidelines Recommend Treatment with Effient(R) for Patients with Acute Coronary Syndromes Managed with PCI
11. Mersana Therapeutics Provides Clinical Update from Ongoing Phase 1 Study of XMT-1001 in Patients with Advanced Solid Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... 2014   Cypher Genomics, Inc., the genome ... Patrick Ravenel as chief technology officer. Ravenel has ... experience and a proven track record of designing and ... "Patrick has been recognized as a top designer and ... known industry-wide for delivering innovative products that operate at ...
(Date:10/1/2014)...   Royal Philips (NYSE: ... and eCareCompanion telehealth applications have received 510(k) clearance ... A part of Philips Hospital to Home,s ... are focused on patient care within the home ... available through the cloud-based digital health platform, which ...
(Date:10/1/2014)... WOONSOCKET, R.I. , Oct. 1, 2014  CVS ... Pharmacists Month for their role in changing the way ... and improve quality in the Company,s retail pharmacies, mail ... "Last month, we changed our company name to CVS ... our expertise in driving the innovations needed to shape ...
Breaking Medicine Technology:Cypher Genomics Appoints J. Patrick Ravenel Chief Technology Officer 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 2CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 3
... (Pink Sheets: APHY ), a pharmacy service healthcare ... medication fulfillment solutions to sufferers of chronic pain, is pleased ... from an existing shareholder which can be converted in whole ... the holder,s option into a maximum of 500 shares of ...
... Sept. 14 ICAP Ocean Tomo , ... (IAP.L) and the world,s premier patent auction firm, ... detection and classification at the upcoming Fall ... 11th. (Logo:   http://photos.prnewswire.com/prnh/20100614/CG20517LOGO ) ...
Cached Medicine Technology:Assured Pharmacy Receives $500,000 in Debt Financing 2Assured Pharmacy Receives $500,000 in Debt Financing 3Skin Lesion Identification System to Auction on November 11th at ICAP Ocean Tomo's Fall 2010 Live IP Auction 2Skin Lesion Identification System to Auction on November 11th at ICAP Ocean Tomo's Fall 2010 Live IP Auction 3
(Date:10/1/2014)... occasion of the Leishmaniasis East Africa Platform meeting, ... leishmaniasis experts, results of a pharmacovigilance or ... carried out by MSF, DNDi, and national partners ... to key decision makers in order to boost ... combination of Sodium Stibogluconate and Paromomycin (SSG&PM) in ...
(Date:10/1/2014)... 01, 2014 October is national Breast ... early detection plans while raising money for breast cancer ... Cancer Awareness Month in the effort to find ... promote the importance of having access to clean, healthy ... be linked to certain forms of cancer. , ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Dr. Saj ... and prosthodontists, is traveling to Chennai, India, tomorrow ... on Oct. 2 and 3. , Dr. Jivraj is ... Hills and Oxnard, Calif., and one of the world’s ... restoration and replacement. He is speaking to the Indian ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Two bicyclists ... take them across the country in an effort to ... military families. The cyclists, a father-daughter team, plan ... beginning in Blaine, Washington and finishing in Key West ... Hope For The Warriors®, a national nonprofit organization that ...
(Date:10/1/2014)... 01, 2014 After undergoing a trial-and-error ... of commerce to join, Living Well Assisted Living at ... in Marin County, the home of its headquarters. , ... moment, and the thought of adding one more activity ... keep looking for the right chamber to join because ...
Breaking Medicine News(10 mins):Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 3Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 4Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 5Health News:Father-Daughter Cycling Duo to Ride Cross-Country to Benefit Hope For The Warriors 2Health News:Living Well Joins San Rafael Chamber of Commerce 2Health News:Living Well Joins San Rafael Chamber of Commerce 3
... at the Congressional Gold Medal ceremony in the Capitol ... Below are the,Speaker,s remarks:, "Good morning. It is ... the House and Senate to honor Dr. Michael DeBakey. ... Representative Al,Green, and others who worked with them for ...
... CHAPEL HILL, N.C., April 23 Global leaders ... as a powerful tool for competing in today,s ... firm Best Practices, LLC.,The study further reveals -- ... strategic process of transforming raw competitive data,into actionable ...
... Foundation (EGPAF), a world leader in the fight against ... totaling $1 million to researchers to support the development ... MD, PhD, professor of medicine at the University of ... Luzuriaga, MD, professor of pediatrics and director of the ...
... FDAnews and Industry Directions Launch New Study, ... FDAnews and Industry Directions Inc., in close,association with ... manufacturers to respond to a new survey on ... company objectives,business processes and practices, information systems and ...
... protein prevents inflammation, hints of new treatments for disease ... they may have discovered how tumors develop in the ... for gastric cancer. , In a study done on ... Ludwig Institute for Cancer Research (LICR) found that blocking ...
... (NYSE: RAI ) will webcast its conference call ... April 30,2008. The call will begin at 9:30 a.m. ... Reynolds American management team will,discuss RAI,s first-quarter results., ... a listen-only basis,at http://www.ReynoldsAmerican.com . Registration for the ...
Cached Medicine News:Health News:Pelosi: 'By Literally Fixing Broken Hearts, Dr. DeBakey Has Given Hope and Health to Millions' 2Health News:Complimentary Excerpt Available from Best Practices: Pharmaceutical Competitive Intelligence Excellence - Optimizing Data Collection within Approved Guidelines 2Health News:UMass Medical School researchers awarded pediatric HIV vaccine development grant 2Health News:UMass Medical School researchers awarded pediatric HIV vaccine development grant 3Health News:Risk Management: Best Practices for Medical Device Profitability 2Health News:Scientists Discover How Stomach Tumors Form 2Health News:RAI to Webcast First Quarter 2008 Earnings Conference Call 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: