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Deadly E. Coli Strain Sequenced With Roche GS Junior System by HPA Scientists - Provides Community Most Complete Assembly to Date
Date:6/15/2011

BRANFORD, Connecticut, June 15, 2011 /PRNewswire/ --


The deadly E. coli O104 strain that has killed dozens and hospitalized thousands across Europe has been sequenced using 454 Life Sciences' benchtop GS Junior sequencing system to generate the "most accurate and detailed genetic analysis to date" of this particularly virulent strain.[1] The sequencing was performed by scientists at the UK's Health Protection Agency and the data has been uploaded onto the National Centre for Biotechnology Information (NCBI) website for use by the scientific community.[2]

The results suggest that the strain has a unique combination of features containing genes from two different types of E. coli as well as its own genes. The sequencing assembly shows that the strain contains two extrachromosomal elements or plasmids which may factor into its pathogenicity. In essence, this strain of E. coli may have 'picked up' some extra genetic material along the way.

"Despite the availability of short read sequencing data from this E. coli outbreak strain for over a week, the short fragmented assembly has offered only limited information on gene order and gene composition," said Chinnappa Kodira, Director of Genomics at 454 Life Sciences. "This long contiguous assembly enables much better characterization of genome structure, horizontal gene transfer and pathogenic islands which are crucial for understanding the emergence of new virulent bacterial strains." The addition of this new long read sequence data from the GS Junior System offers the community the most contiguous sequence to date, and provides a comprehensive assembly on which subsequent genomic analysis can be performed.

The long shotgun reads generated using the 454 Sequencing System allowed the HPA scientists to assemble almost the entire genome into a comprehensive and detailed genomic map of this pathogen
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SOURCE Roche Diagnostics GmbH
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