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De nouvelles directives recommandent la fidaxomicine pour tous les patients pouvant suivre un traitement antibiotique par voie orale pour une infection à Clostridium difficile
Date:10/29/2013

sociée à un taux de mortalité pouvant atteindre 14 % chez les personnes âgées. [15] Par ailleurs, les patients cancéreux hospitalisés traités pour une ICD subissent des séjours prolongés en hôpital.[16] Des maladies rénales progressives sont associées à une durée plus longue de résolution des diarrhées, des taux de guérison moins élevés et une incidence plus élevée de récurrence chez les patients traités pour une ICD.[14] Les patients hospitalisés à long terme courent un risque particulièrement important avec un taux de récurrence pouvant atteindre 50 % au cours d'une période de six mois lorsque l'ICD a été contractée pendant la période d'hospitalisation.[17] Des taux de mortalité pouvant atteindre 45 % des patients en soins intensifs de plus de 65 ans ont été signalés.[18] Conformément à la nouvelle version du document de directives de traitement ESCMID, DIFICLIR est recommandé pour les patients pouvant suivre un traitement antibiotique par voie orale, dans ces sous-populations de patients vulnérables.

« L'ICD est potentiellement fatale et a un impact majeur sur la santé et la qualité de vie des patients. Nous espérons que le respect de ces recommandations permettra une meilleure gestion de l'ICD et le traitement des récurrences », déclare Ken Jones, PDG d'Astellas Pharma Europe Ltd.

Le document précédent de directives de l'ESCMID a été publié en 2009[19] et a fait l'objet d'une application importante en milieu clinique. Cependant, avec le développement de nouveaux traitements de l'ICD, une mise à jour de ce document était nécessaire pour uniformise
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SOURCE Astellas Pharma Europe Ltd
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