Navigation Links
DavosLife: Vitamin E Tocotrienol Shows Increased Cancer Cell Apoptosis Without Toxicity in Phase 1 Pancreatic Cancer Trial
Date:5/30/2011

SINGAPORE, May 30, 2011 /PRNewswire-Asia/ -- Davos Life Science (DavosLife) has today announced preliminary results of a phase I clinical trial of its Natural e3 delta-tocotrienol (Natural e3) in patients with resectable pancreatic cancer. Tocotrienols are highly potent members of the Vitamin E family that have been found by researchers to inhibit the growth and survival of various types of cancer cells. This clinical trial revealed that Natural e3 was able to increase apoptosis (cell death) in pancreatic cancer tumours, with no toxicity. The study was carried out by researchers at The H. Lee Moffitt Cancer Center & Research Institute in Florida, United States, and supported by DavosLife and by the U.S. National Institute of Health. This data was presented by the Moffitt Cancer Center at the recent American Association for Cancer Research (AACR) Annual Meeting.

For a period of 2 weeks prior to surgery, 12 subjects received Natural e3, with 3 subjects at each dose level of 200 mg, 400 mg, 600 mg and 800 mg per day. This oral treatment occurred pre-surgery to examine the effect of Natural e3 on the resected pancreatic cancer tumour. To assess for toxicity, blood samples were collected pre-dose on day 1, day 8, on the day of the patients' surgery and 3-6 weeks post-surgery. This trial occurred between October 2009 and August 2010.

The Moffitt Cancer Center researchers, led by Dr Mokenge Malafa, found no adverse drug-related events in the patients and no change in the rate of post-operative complications at doses up to 800 mg per day. They also found that giving patients daily doses of Natural e3 greater than 200 mg increased apoptosis in the pancreatic tumours as well as increased expression of p27, an important kinase inhibitor involved in the regulation of the cell cycle. Reduced levels of p27 have been found in some types of cancers.

"Pancreatic cancer is a highly fatal form of cancer with average 5 year survival rates at less than 10%
'/>"/>

SOURCE Davos Life Science Pte Ltd
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing
2. Free Prostate Cancer Seminar in Lake Ridge, VA: Dr. Charles Snuffy Myers Announces Vitamin D Clinical Trials
3. Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12
4. Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Supplementation
5. Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin
6. Evidence Lacking in Multivitamin Study of Womens Risk of Cancer, Heart Disease or Death, Says Natural Products Association
7. Harvard Study Shows Folic Acid, B Vitamins in Animi-3(R) May Prevent Vision Loss
8. Researchers Say More Aggressive Vitamin D Supplementation Needed in Obese Cancer Patients
9. Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients
10. July 2009 Mayo Clinic Womens HealthSource Highlights Food Storage Safety, Energy Therapies and Vitamins and Minerals
11. VitaminSpice Appoints Dr. Richard F. Seelig as Director
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/13/2014)... , Dec. 11, 2014 Research and Markets ... addition of the "Drug Injection Devices to ... http://photos.prnewswire.com/prnh/20130307/600769 As ... an expanding list of health conditions, drug developers ... simplify the administration process and increase the efficiency ...
(Date:12/13/2014)... Dec. 12, 2014 HudsonAlpha Institute for ... X Ten sequencing system manufactured by Illumina, Inc. ... produce and analyze genomic data faster and at ... Institute,s commitment to research programs for genomics excellence ... Ten provides unprecedented capacity, speed and accuracy for ...
(Date:12/13/2014)... , Dec. 12, 2014  Novo Nordisk, a world leader ... announced a multi-year extension of their partnership, that will renew ... Novo Nordisk Chip Ganassi Racing entry, driven by Charlie ... Kimball, 29, from Camarillo, California , is ... history of INDYCAR to win a race at the most ...
Breaking Medicine Technology:Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... Interventional Radiology Treatment Relieves Pain From Herniated Disks; ... but With Fewer Complications, Shorter Recovery TimeSAN DIEGO, ... treatment--that safely and effectively uses oxygen/ozone to relieve ... the United States in the next few years, ...
... Minimally Invasive "Lumpectomy" -- as Effective as Surgery -- ... Mapping Biopsy Changed Patients, Management 70 Percent of the ... -- a minimally invasive interventional radiology treatment for prostate ... diseased tumors and can be considered a first-line treatment ...
Cached Medicine Technology:Oh, My Aching Back: Give Me a Shot of Ozone 2Oh, My Aching Back: Give Me a Shot of Ozone 3Oh, My Aching Back: Give Me a Shot of Ozone 4Oh, My Aching Back: Give Me a Shot of Ozone 5Freezing Prostate Cancer Does a Man's Body Good 2Freezing Prostate Cancer Does a Man's Body Good 3Freezing Prostate Cancer Does a Man's Body Good 4Freezing Prostate Cancer Does a Man's Body Good 5Freezing Prostate Cancer Does a Man's Body Good 6Freezing Prostate Cancer Does a Man's Body Good 7
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... , , , SEATTLE, Sept. ... actuarial firms, announced today that it has opened a new office ... Milliman offices, will continue to serve existing clients while expanding the ... "Milliman,s wide range of talents and sixty-plus years of ...
... , , RADNOR, ... will be the guest speaker at Feeling Blue Suicide Prevention Council,s ... Eric Hipple is a former National Football League (NFL) ... Hipple,s accomplishments include two playoff bids, a divisional championship, and the ...
... , SAN DIEGO, Sept. 22 ... that it has initiated a relationship with Kentucky Bioprocessing ... the active affinity agents immobilized within the Aethlon Hemopurifier(R). ... capture a broad-spectrum of viruses from blood and other ...
... , , , ... that it has received certification to the ISO 13485:2003 ... Surgical Adhesives. Receipt of the certification allows Cohera ... approval process for TissuGlu(R), the company,s novel internal surgical ...
... PITTSBURGH, Sept. 22 Precision Therapeutics today announced ... the Smart Business Magazine 2009 Pacesetters Award. This award ... who are setting the pace for the region. The ... their influence in the community-at-large as well as within their ...
... , , , ... FIRST(R) - BXN Mouthwash. It is the second in the FIRST(R) ... BLM. The active ingredients in FIRST(R) - BXN Mouthwash are ... Magic Mouthwash containing Benadryl(R), Xylocaine 2% viscous(R), and nystatin. The kits ...
Cached Medicine News:Health News:Milliman Announces the Opening of a New Office in San Juan, Puerto Rico 2Health News:Former NFL Quarterback to Speak at Local Nonprofit Fundraising Event 2Health News:Aethlon Medical Initiates Relationship to Establish Large Scale Production of Hemopurifier(R) Affinity Agents 2Health News:Aethlon Medical Initiates Relationship to Establish Large Scale Production of Hemopurifier(R) Affinity Agents 3Health News:Cohera Medical Receives ISO 13485 Certification: Company Meets International Standards for Design, Development and Manufacturing of Medical Devices 2Health News:Precision Therapeutics President and CEO Sean McDonald Recipient of 2009 Pacesetters Award 2Health News:CutisPharma Launches New Prescription Mouthwash Kit Adding to Product Line 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: