Navigation Links
Data from Study of Elderly Depressed Patients are Reported for Investigational Compound Lu AA21004 on Symptoms of Major Depressive Disorder (MDD)
Date:5/8/2012

ring additional options to people who suffer from the challenging and diverse symptoms of depression."

"These study results contribute to the growing understanding of the compound," said Stephen Brannan, M.D., Development Therapeutic Area Head, CNS, at Takeda. "Lundbeck and Takeda are committed to further investigating Lu AA21004 to better understand its mechanism of action in depression."

The study was a multi-national, randomized, double-blind, placebo-controlled, active-reference, fixed-dose study in elderly patients (n=452) with recurrent MDD, assessing the efficacy and tolerability of Lu AA21004 5 mg/day.  The primary endpoint was mean change from baseline in the 24-item Hamilton Depression Rating Scale (HAM-D24) total score, a measure of the severity of MDD.  These patients, aged 65 years or older, with a current major depressive episode (MDE) of at least 4-week duration, at least one previous MDE before the age of 60 years, a MADRS total score of 26 or more and a Mini Mental State Examination score of <24, were randomly assigned (1:1:1) to Lu AA21004 5 mg/day, duloxetine 60mg/day (active reference), or placebo for 8 weeks.

Withdrawal rates due to adverse events were 5.8% (Lu AA21004) and 2.8% (placebo). Nausea was reported with a significantly higher incidence for Lu AA21004 (21.8%) than for placebo (8.3%).

About Lu AA21004

Lu AA21004 is under investigation as a multimodal anti-depressant that is thought to work through a combination of two complementary mechanisms of actions: receptor activity modulation and reuptake inhibition.

In vitro studies indicate that LuAA21004 is a 5-HT3 and 5-HT7 receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the SERT. In vivo non-clinical studies have demonstrated that LuAA21004 modulates neuronal firing and neurotransmitter release in multiple systems, resulting in enhanced levels of serotonin, noradrenaline, dopamine,
'/>"/>

SOURCE H. Lundbeck A/S; Takeda Global Research & Development Center, Inc., U.S.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 24, 2014 Kinex Pharmaceuticals ... with KX2-361 at Roswell Park Cancer Institute. ... molecule drug that has shown potent inhibitory activity against ... those that are resistant to Temozolomide (T98G), the most ... In a well-established brain tumor mouse model, KX2-361 consistently ...
(Date:12/24/2014)... FLINT, Mich. , Dec. 24, 2014  Diplomat ... largest independent specialty pharmacy, is proud to announce ... and quality at Diplomat, will take office as the ... 2015. The formal induction ceremony will take place Feb. ... which will be held at the Renaissance Center in ...
(Date:12/24/2014)... Echo Therapeutics, Inc. (NASDAQ: ... skin permeation, continuous glucose monitoring and associated technologies, ... has been appointed Chief Executive Officer effective December ... years of experience in the medical device, pharmaceutical ... as Vice President, Business Development, Otsuka Pharmaceuticals as well ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... Healthcare Products Association (CHPA), representing makers of over-the-counter ... U.S. Food and Drug Administration (FDA) efforts to ... right amount of medicine. Today, the FDA,s Nonprescription ... enhancing the labels of all OTC single-ingredient pediatric ...
... 2011 Eli Lilly and Company (NYSE: LLY ... scientific and medical officer of the American Diabetes Association, has ... from his current role in late-July. In his ... for Lilly Diabetes in advocacy and clinical science communities and ...
Cached Medicine Technology:OTC Industry Supports FDA Advisory Committee Recommendations on New Dosing Instructions 2OTC Industry Supports FDA Advisory Committee Recommendations on New Dosing Instructions 3David M. Kendall, M.D., Named Distinguished Medical Fellow at Lilly 2David M. Kendall, M.D., Named Distinguished Medical Fellow at Lilly 3
(Date:12/25/2014)... Dallas, TX (PRWEB) December 26, 2014 ... and Market Analysis to 2023” focuses on the ... commercial opportunities in the colorectal cancer market. Stivarga ... treatment of colon or rectal cancer. Boehringer Ingelheim ... inhibitor, for the treatment of refractory CRC in ...
(Date:12/25/2014)... Dylan Queen, a famous online company supplying women’s special ... prom dresses, most of which are priced under $200. ... the promotion is valid until Jan. 22, 2015; the ... market. , The prom dresses in this new collection ... strapless, empire strapless chiffon, one shoulder, floor-length, V-neck beading, ...
(Date:12/25/2014)... When head lice hits a home or school, parents and ... of it while keeping it from taking over the house ... solution right in their neighborhood: Lice Troopers . Expanding ... spectrum head lice screening and treatment services to families and ... Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , The ...
(Date:12/25/2014)... WEDNESDAY, Dec. 24, 2014 (HealthDay News) -- Among early ... treatment, less than half of one percent will eventually ... new analysis reveals. The finding comes from a ... between 1998 and 2007, and it suggests that the ... double what experts had previously thought. "The frequency ...
(Date:12/25/2014)... Aliso Viejo, California (PRWEB) December 25, 2014 ... the release of ProFire 5k. A fully customizable business ... X . , “Adding the ProFire 5k business tool, ... style” Said Christina Austin, CEO of Pixel Film Studios. ... the look and style to add professionalism to a ...
Breaking Medicine News(10 mins):Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2
... an easy,fun and inexpensive way to stay fit have ... Vol.2 ( www.kideosyncrasy.com ) is a fun tool for,teaching ... jam-packed with live-action;,kids-teaching-kids how to easily step into fun ... on nutrition and exercise, Kideosyncrasy,promotes health and fitness in ...
... Board recognized at National Capital Philanthropy Day Awards , ... ... -- James W. Lintott, chairman of the board of the ... as "Outstanding Fundraising Volunteer" at the National Capital Philanthropy Day ...
... one Year Anniversary as a Non-Smoker 60 Pounds Lighter. What Joe did ... or lose 60 pounds but to do both within one year is truly ... to turn his life around and improve his quality of life; he has ... ...
... 19 Household budget cutbacks are becoming commonplace as most ... health care needs should not be among the forfeited services. ... have cut back on medical visits to save money and ... serious consequences. , , "During ...
... giving antiretroviral therapy (ART) immediately to those found infected with ... report in the New England Journal of Medicine . ... at an average age of 7 weeks made them four ... compared with postponing ART until signs of illness or a ...
... Gives Atria Senior Living Honorable Mention While Atria Defends Against ... Nov. 19 On Nov. 17, the Employer ... winners of its "2008 Great California Workplaces Award," giving Honorable ... assisted living providers. , , ...
Cached Medicine News:Health News:Give Kids the Gift of Fun and Fitness This Holiday Season 2Health News:James W. Lintott Named Outstanding Fundraising Volunteer Of The Year 2Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 2Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 3Health News:Even in Poor Economy, Consumers Urged to Prioritize Health Care 2Health News:Landmark study defines benefits of early HIV testing and treatment for infected infants 2Health News:Landmark study defines benefits of early HIV testing and treatment for infected infants 3Health News:'Great California Workplace Award' Goes to Company Facing Lawsuits, Possible Federal Complaint 2
... holes and additional electrode tip insulation, ... dissection with decreased risk of collateral ... ,Flexible design options allow the choice ... multiple tip designs. Optimize specific surgical ...
... Enhanced features including aspiration holes and ... laparoscopic procedures requiring precise dissection with ... increased suction demands. ,Flexible design ... and nonretractable electrodes and multiple tip ...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Medicine Products: