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Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet
Date:9/25/2008

PRINCETON, N.J., Sept. 25 /PRNewswire/ -- Data from a 52-week phase 3 study (LEADTM 3) of Novo Nordisk's (NYSE: NVO) liraglutide, a once-daily human GLP-1 analog, were published online today in The Lancet. The study showed that liraglutide, when taken alone, produces statistically significant and sustained improvements in blood sugar control in patients with early type 2 diabetes, as compared with glimepiride, a widely used oral anti-diabetic drug. Moreover, the treatment with liraglutide led to weight loss, reduced systolic blood pressure and lowered rates of hypoglycemia after 52 weeks of treatment.

"Publication of this data in The Lancet means that more physicians will have access to these key results on liraglutide's efficacy as monotherapy in the treatment of type 2 diabetes," said principal study investigator Alan Garber, MD, Professor of Medicine, Biochemistry & Molecular Biology, and Molecular & Cellular Biology Division of Diabetes, Endocrinology & Metabolism, Baylor College of Medicine, Texas. "In addition to effective glycemic control for at least one year, liraglutide treatment also led to a number of other clinical benefits when given to patients early on in the course of their disease."

Type 2 diabetes is a progressive disease. Many treatments are effective early on in the course of the disease but do not maintain their effectiveness. After 52 weeks of treatment, 62% of treatment-naive patients treated with liraglutide 1.8 mg achieved an average reduction in blood sugar below the American Diabetes Association target for HbA1c of less than 7% and maintained this reduction over the 52-week study period.

In addition, patients treated with liraglutide had significant weight loss. A mean weight loss of 2.05+/-
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SOURCE Novo Nordisk
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