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Data for Investigational Tiotropium Show Improved Lung Function and Sustained Bronchodilation in Patients with Moderate Asthma Severity
Date:9/10/2013

rol 50 mcg

123 mL
(P < 0.0001)

106 mL
(P < 0.0001)

114 mL
(P < 0.0001)To characterize the treatment response as greater than or equal to 0.5, measured by the ACQ, treatment with tiotropium (either 2.5 mcg or 5 mcg) resulted in a statistically significant improvement in the ACQ responder rate at 24 weeks compared with placebo and comparable to that of salmeterol. ACQ responder rates, performed on the pooled MezzoTinA-asthma results, were as follows:

  • Placebo: 57.7 percent (n=299/518)
  • Tiotropium 2.5 mcg once daily: 64.5 percent (n=332/515; P = 0.03)
  • Tiotropium 5 mcg once daily: 64.3 percent (n=330/513; P = 0.03)
  • Salmeterol 50 mcg twice daily: 66.5 percent (n=356/535; P = 0.004)
  • Patients in the MezzoTinA-asthma® studies were permitted to receive additional background therapy, including antihistamines, nasal steroids and leukotriene modifiers. Long-acting beta agonists (LABAs) were not permitted during the study (salmeterol was included as an active comparator for the trial).

    Adverse events were balanced across the four treatment groups groups in the pooled analysis with 58.2 percent of patients receiving tiotropium 2.5 mcg once daily reporting an adverse event compared to 57.3 percent of patients in the tiotropium 5 mcg once daily group, 54.3 percent of patients who received salmeterol 50 mcg twice daily and 59.1 percent of patients receiving placebo. The most commonly reported adverse events* were asthma, peak expiratory flow (PEF) rate decreased, nasopharyngitis and upper respiratory tract infection.

    About the UniTinA-Asthma® Clinical Trial Program
    The MezzoTinA-asthma® studies are a part of the comprehensive Phase 3 trial program, UniTinA-asthma®, which includes a number of clinical trials in adults, adolescents and pediatric patients across dif
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    SOURCE Boehringer Ingelheim
    Copyright©2012 PR Newswire.
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