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Data for Investigational Tiotropium Show Improved Lung Function and Sustained Bronchodilation in Patients with Moderate Asthma Severity
Date:9/10/2013

the pooled MezzoTinA-asthma® results.

In the individual trials and the pooled analysis being presented at ERS, the mean change in peak FEV1 at 24 weeks from baseline versus placebo was significantly improved for all three active treatments:MezzoTinA-
asthma® 1

MezzoTinA-
asthma® 2

Pooled AnalysisAdjusted mean
FEV1 AUC0-3
difference from
placebo

Adjusted mean
FEV1 AUC0-3
difference from
placebo

Adjusted mean
FEV1 AUC0-3
difference from
placeboTiotropium 2.5 mcg

236 mL
(P < 0.0001)

211 mL
(P < 0.0001)

223 mL

(P < 0.0001)Tiotropium  5 mcg

198 mL
(P < 0.0001)

169 mL
(P < 0.0001)

185 mL
(P < 0.0001)Salmeterol 50 mcg

213 mL
(P < 0.0001)

176 mL
(P < 0.0001)

196 mL
(P < 0.0001)Additionally, the mean change in trough FEV1 at 24 weeks from baseline versus placebo in the individual trials, as well as in the pooled data being presented at ERS, was significantly improved for all three active treatments:MezzoTinA-
asthma® 1

MezzoTinA-
asthma® 2

Pooled AnalysisAdjusted mean
trough FEV1
difference from
placebo

Adjusted mean
trough FEV1
difference from
placebo

Adjusted mean
trough FEV1
difference from
placeboTiotropium 2.5 mcg

185 mL
(P < 0.0001)

176 mL
(P < 0.0001)

180 mL

(P < 0.0001)Tiotropium  5 mcg

152 mL
(P < 0.0001)

133 mL
(P < 0.0001)

146 mL
(P < 0.0001)Salmete
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SOURCE Boehringer Ingelheim
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