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Data for Investigational Tiotropium Show Improved Lung Function and Sustained Bronchodilation in Patients with Moderate Asthma Severity
Date:9/10/2013

RIDGEFIELD, Conn., Sept. 10, 2013 /PRNewswire/ -- Boehringer Ingelheim will present a pooled analysis of new data from the Phase 3 UniTinA-asthma® program at the European Respiratory Society (ERS) Annual Congress 2013 in Barcelona. The data from the individual MezzoTinA-asthma® Phase 3 studies (NCT01340209 and NCT00565266), from which the pooled data are derived, show the addition of tiotropium delivered via the Respimat® inhaler to medium-dose maintenance inhaled corticosteroid (ICS) therapy (defined as 400-800 mcg budesonide/day or equivalent) improved lung function and provided sustained bronchodilation over 24 hours in patients with moderate asthma and airflow limitation. Tiotropium is being investigated to determine the medicine's efficacy in treating asthma patients and is not currently approved for this indication.

These new data from the MezzoTinA-asthma® Phase 3 studies also showed the addition of once-daily tiotropium delivered via the Respimat® inhaler provided a statistically significant improvement in asthma control responder rate, as measured by the Asthma Control Questionnaire (ACQ).

"These results give us insight into the potential efficacy of tiotropium in the subset of asthma patients who remain symptomatic despite using medium-dose ICS and show that the addition of tiotropium may provide improvements in asthma control and lung function that could be clinically meaningful," said lead study author Professor Huib A.M. Kerstjens of the University Medical Centre, Groningen, The Netherlands. "A significant proportion of asthma patients trea
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SOURCE Boehringer Ingelheim
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