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Data Underscore Promise of Satori Pharmaceuticals' Gamma-Secretase Modulator Program in Treatment of Alzheimer's Disease
Date:7/18/2012

CAMBRIDGE, Mass., July 18, 2012 /PRNewswire/ -- Satori Pharmaceuticals, a company dedicated to developing life-changing therapeutics for Alzheimer's disease (AD), announced today that its lead compound, a gamma-secretase modulator (GSM), is efficacious in preclinical models following single or multi-day dosing. This oral presentation, as well as two poster presentations related to the characteristics of Satori's GSMs, was presented at the Alzheimer's Association International Conference (AAIC) in Vancouver, British Columbia.

"These findings help demonstrate that our lead development candidate – SPI-1865 – has the potential to be an efficacious new therapy for Alzheimer's disease," said Barbara Tate, Ph.D., Vice President of Research for Satori Pharmaceuticals. "SPI-1865 selectively reduces AB42 while sparing total AB, which serves to lower the ratio of this neurotoxic peptide to other AB peptides, returning the levels closer to the ratio seen in healthy human brains. This has advantages when compared with other classes of drugs that cannot selectively target this form of AB that is strongly implicated in plaque formation and neurodegeneration."

Satori gamma-secretase modulators are efficacious in wild type rodents following either acute or steady-state dosing

In an oral presentation on Sunday, July 15, lead study author Robyn M.B. Loureiro presented data that demonstrated Satori's GSM compounds are selective for AB42, penetrate the brain, and are dose responsive at achievable exposure levels.

Sprague-Dawley rats were dosed via oral gavage either in a single acute dose or once a day dosing for six days. Brain AB levels were measured 24 hours post final dose for effects on AB38, AB40 and AB42 using a sensitive plate based ELISA system (MSD). The brain and plasma exposure were assessed by LC/MS/MS.  

Notably, SPI-1865 is able to robustly and selectively reduce both AB42 and AB38 while sparing AB40 in vivo<
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SOURCE Satori Pharmaceuticals
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