Navigation Links
Data Underscore Promise of Satori Pharmaceuticals' Gamma-Secretase Modulator Program in Treatment of Alzheimer's Disease
Date:7/18/2012

CAMBRIDGE, Mass., July 18, 2012 /PRNewswire/ -- Satori Pharmaceuticals, a company dedicated to developing life-changing therapeutics for Alzheimer's disease (AD), announced today that its lead compound, a gamma-secretase modulator (GSM), is efficacious in preclinical models following single or multi-day dosing. This oral presentation, as well as two poster presentations related to the characteristics of Satori's GSMs, was presented at the Alzheimer's Association International Conference (AAIC) in Vancouver, British Columbia.

"These findings help demonstrate that our lead development candidate – SPI-1865 – has the potential to be an efficacious new therapy for Alzheimer's disease," said Barbara Tate, Ph.D., Vice President of Research for Satori Pharmaceuticals. "SPI-1865 selectively reduces AB42 while sparing total AB, which serves to lower the ratio of this neurotoxic peptide to other AB peptides, returning the levels closer to the ratio seen in healthy human brains. This has advantages when compared with other classes of drugs that cannot selectively target this form of AB that is strongly implicated in plaque formation and neurodegeneration."

Satori gamma-secretase modulators are efficacious in wild type rodents following either acute or steady-state dosing

In an oral presentation on Sunday, July 15, lead study author Robyn M.B. Loureiro presented data that demonstrated Satori's GSM compounds are selective for AB42, penetrate the brain, and are dose responsive at achievable exposure levels.

Sprague-Dawley rats were dosed via oral gavage either in a single acute dose or once a day dosing for six days. Brain AB levels were measured 24 hours post final dose for effects on AB38, AB40 and AB42 using a sensitive plate based ELISA system (MSD). The brain and plasma exposure were assessed by LC/MS/MS.  

Notably, SPI-1865 is able to robustly and selectively reduce both AB42 and AB38 while sparing AB40 in vivo<
'/>"/>

SOURCE Satori Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Multi-Targeted Therapies - New Wave of Combination Therapies in Late Stage Development for Lung Cancer Offer Promise
2. Satori Pharmaceuticals to Present Data Highlighting Promise of Gamma-Secretase Modulators in Treatment of Alzheimers Disease
3. Drug Delivery Technologies Show Promise of Improving Clinical Outcomes for Patients at PODD: Partnership Opportunities in Drug Delivery Conference
4. Ampio Pharmaceuticals Announces Closing of Public Offering
5. Pharmaceuticals Play Key Role in Achieving ACO Quality, Cost Goals
6. Savient Pharmaceuticals to Hold Second Quarter 2012 Financial Results Conference Call on Wednesday, August 8, 2012
7. Conatus Pharmaceuticals Appoints Daniel Ripley As Head Of Corporate Development
8. Direct to Consumer (DTC) Advertising in Pharmaceuticals - Shift from Traditional Mass-Media Platforms towards Personalization via Online and Social Media
9. Valeant Pharmaceuticals To Announce 2012 Second Quarter Results On August 2, 2012
10. 81,200 Square Foot Lease Extension In San Diego Through 2018 Signed By Vertex Pharmaceuticals And BioMed Realty
11. Anthera Pharmaceuticals Provides Additional Data from the Recently Completed PEARL-SC Study of Blisibimod in the Proposed Phase 3 Population
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Oct. 21, 2014   BioNano Genomics , ... genomics research centers to purchase an Irys™ System ... National Cancer Institute (NCI), NIH Intramural Sequencing Center (NISC) ... Irys, obtaining a comprehensive view of a genome ... (NGS) does not deliver the scalability or reliability ...
(Date:10/22/2014)... 21, 2014 Abaxis, Inc. (NasdaqGS: ... analysis systems, today reported financial results for the second ... quarter overview: , Revenues of $53.9 million, up ... EPS of $0.24, up 33% over last year,s comparable ... from Abaxis Veterinary Reference Laboratories (AVRL) of $3.5 million, ...
(Date:10/22/2014)...   Surefire Medical , Inc., the developer of ... targeted delivery of embolization agents in minimally invasive direct-to-tumor ... John R. Daniels , MD of the University of ... Steven C. Katz , MD of the Roger ... Board (SAB).    "The role of the ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14Surefire Medical's Scientific Advisory Board Expands, Broadens Clinical Trial Expertise 2
... SAN MATEO, Calif., Dec. 21, 2011 Doximity, the largest ... has partnered with several expert network firms to power ... in the industry and collectively paid over $100 million ... ExpertFinder service, they can instantly search detailed CVs of ...
... Biotechnology Corporation (OTCBB: GNBT.OB) today announced that the ... Express breast cancer vaccine aired yesterday evening (December ... the Company,s website at www.generex.com or ... (Logo: http://photos.prnewswire.com/prnh/20110106/NY25057LOGO-b ) ...
Cached Medicine Technology:Doximity Launches ExpertFinder to Match Clinical Need with Clinical Experts 2Generex Announces Airing of Antigen Express Breast Cancer Vaccine Segment on Bloomberg Television 2Generex Announces Airing of Antigen Express Breast Cancer Vaccine Segment on Bloomberg Television 3
(Date:10/25/2014)... New York, New York (PRWEB) October 25, 2014 ... of transvaginal mesh lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) ... multidistrict litigation underway in U.S. District Court, Southern ... Motion for Summary Judgment on Punitive Damages in ... Florida plaintiffs. In a ruling issued on October ...
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Not getting ... of ulcerative colitis, a new study suggests. Those ... to eight hours per night may be more prone ... the intestines, researchers report. The study authors concluded that ... be considered among patients with inflammatory bowel diseases. ...
(Date:10/25/2014)... (HealthDay News) -- October,s shorter, darker days can trigger ... according to an expert. People affected by ... tired, lack motivation and even have trouble getting out ... suicide, said Dr. Angelos Halaris, a professor in the ... Chicago Stitch School of Medicine. "Seasonal affective disorder ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Isabel ... of Allied Health Professions (ASAHP) Conference on October 22-24 ... CEO will participate in a panel discussion on Technology ... , Isabel Healthcare provides a diagnostic decision support tool ... the diagnosis skills of students and clinical learners. The ...
(Date:10/22/2014)... RESTON, Va. (PRWEB) October 22, 2014 ... Healthcare Innovation , which is dedicated to distribute ... efficiency of healthcare delivery worldwide announced the development ... in which patients expect when receiving healthcare. These ... definition for patient-centered care: “providing care that is ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2
... & Decision is adding eClinical solutions to its established Life ... ... operations., PHILADELPHIA, Nov. 13 ... American,eClinical Division. This line of business will focus on providing,Pharmaceutical, Biotechnology, ...
... buyer for iFire Technology Corp., CALGARY, Nov. 13 ... third quarter ended September 30, 2007, it,recorded a net ... on revenues of,$7.8 million. In the same quarter last ... or 10 cents per share, on revenues of $8.2 ...
... TORONTO, CDA. A massive survey conducted by researchers ... states with high rates of income inequality are significantly ... completion of daily tasks such as dressing, bathing and ... personal income and education can affect ones health outcomes, ...
... calls vaccine ,family priority, this season , , TUESDAY, Nov. 13 ... Alias ) and the heart of husband Ben Affleck. ... to protect the health of the couple,s 2-year-old daughter, Violet. ... 100 children die every year from this disease -- these ...
... than six out of ten people with diabetes are ... serious foot problems that could lead to amputation, according ... International Journal of Clinical Practice. , Published to ... by the University of Dundee, has been welcomed by ...
... Stone formation is an important feature of chronic pancreatitis, ... large in size, highly irregular in shape and cause ... is not well-understood. It is very important to understand ... controlled before it causes obstruction and damage to the ...
Cached Medicine News:Health News:Business & Decision Brings its eClinical Life Sciences Industry offering to North America 2Health News:Business & Decision Brings its eClinical Life Sciences Industry offering to North America 3Health News:Westaim announces 2007 third quarter results 2Health News:Westaim announces 2007 third quarter results 3Health News:Westaim announces 2007 third quarter results 4Health News:Risk of disability rises in states with income inequality 2Health News:Jennifer Garner Puts Flu Shot in the Spotlight 2Health News:Jennifer Garner Puts Flu Shot in the Spotlight 3Health News:Jennifer Garner Puts Flu Shot in the Spotlight 4Health News:63 percent of diabetics risk serious foot problems by wearing the wrong-sized shoes 2Health News:The most important candidate genes for pancreatic stone formation 2
... Made with elastic fabric, these head ... you need to begin testing. Each Electro-Cap ... to the International 10-20 System. When you ... you are using with your head cap ...
... orbital implant was conceived by Arthur C. ... a comprehensive review of the literature on ... dating back to 1885 (Mules 1885). This ... the performance of contemporary implants, allowed Perry ...
... Evisceration. The new MEDPOR PLUS ... MEDPOR Spheres with a bioactive glass ... throughout the sphere structure, promotes more ... PLUS sphere., ,MEDPOR is a biocompatible ...
... The STAAR Collamer ICL and the TORIC ... Made of Collamer, STAARs proprietary collagen copolymer, ... the ciliary sulcus. This unique material contains ... excellent biocompatibility and superior optical capability. The ...
Medicine Products: