Navigation Links
Data Support use of SuperGen's CLIMB Technology in Lead Development and Optimization
Date:10/25/2007

Proprietary technology identifies small molecule JAK2 and Pim kinase

inhibitors

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced data as part of a series of presentations at the 2007 AACR-NCI-EORTC International Conference that describe how its proprietary CLIMB technology was used in lead development and design of small molecule JAK2 and Pim kinase inhibitors (Posters C200 and C208).

Poster C200 (Abstract No. 907)

Effect of small molecule inhibitors of JAK2 kinase on modulating signaling cascades downstream of cytokine receptors

Janus kinases (JAKs) are critical to a number of intracellular signaling pathways. Dysregulation of JAK2 signaling has been implicated in myoproliferative disorders, leukemia, lymphoma and various solid tumors. Utilizing CLIMB, SuperGen's proprietary technology, scientists used a JAK2 crystal structure to build several models that were made into a substrate for screening a large, virtual small molecule library. This process generated a subset of leads that were screened using in silico algorithms to identify "druggable" candidates to pursue.

Poster C208 (Abstract No. 985)

A small molecule inhibitor of Pim-1 kinase with activity in both hematological and solid tumor malignancies

Pim-1 kinase is involved in signaling pathways as a potent inhibitor of programmed cell death (apoptosis). Pim-1 is over expressed in many cancer types, including AML, CML, bladder and oral cancers. Scientists used SuperGen's CLIMB technology to build a model that allowed for the prediction of small molecule inhibitors. Leads were screened to identify those with inhibitory activity with low nanomolar IC50 concentrations. Data support further development of the lead compounds in liquid a
'/>"/>

SOURCE SuperGen Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
2. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
3. Pharmacyclics Announces Interim Results From Two Ongoing Phase 2 Trials Supporting Potential of Xcytrin Plus Chemotherapy to Treat Recurrent Non-Small Cell Lung Cancer
4. Infertile Voice Supports Stem Cell Research: RESOLVE Calls for Patient Options in Using Frozen Embryos
5. President Bush Ignores Americas Plea for Support of Stem Cell Research
6. Vastox Awarded £400,000 Grant to Support R&D at Carbohydrate Chemistry Facility
7. Diabetes drug supported by Mexican Diabetes Federation
8. Data Showing that ReGens Colostrinin Supports Healthy Cognitive Function Presented at the 2007 International Congress on Natural Medicine in Australia
9. Newly Published Data from Large Study Support Cardiovascular Safety of Avandia (Rosiglitazone Maleate)
10. Investigation Findings, Corroborated by Empirical Evidence of the Schisandra Berry as Cardio-Tonic in Traditional Chinese Medicine for Hundreds of Years, Support the Use of Schisandrin B in the Prevention and Treatment of IHD
11. Independent publication supports the profile of CeNeS phase II compound, CNS 5161
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)...  Actavis plc (NYSE: ACT ) ... complete response letter from the U.S. Food and ... (NDA) for the fixed-dose combination (FDC) of nebivolol ... Photo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO ... of a complete response letter, Actavis remains committed ...
(Date:12/24/2014)... 24, 2014  The International Trade Commission (ITC) issued its ... BMC Medical. In a notice issued on December 23, the ... patent on its humidifier was invalid. BMC President, ... "We are very excited with the ITC,s decision in this ... have taken since the very beginning on the key patents ...
(Date:12/24/2014)... Dec. 23, 2014 PuraMed BioScience®, Inc., (OTC ... (OTC) medicinal and healthcare products, announced it received the ... a hemp-based, advanced headache relief product, for planned distribution ... Colorado , Washington State ... With the MigraPure H Advanced headache relief gel formulation ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
... BEND, Oregon, December 15 Bend Research Inc. announced,today that its ... used in technologies developed by the firm to enhance the oral,bioavailability ... clients may now reference a Type V Drug Master File (DMF),for ... , "We,re excited about this new development ...
... , MALVERN, Pa., Dec. 14 Fujirebio Diagnostics Inc., ... the Year by the Eastern Technology Council at a gala ... December 3, 2009. , The Eastern Technology Council ... association. Known as "The Academy Awards" of the Technology and ...
Cached Medicine Technology:Bend Research Clients May Now Reference Key Safety Document for Important Solubility Excipient 2Fujirebio Diagnostics Named Life Sciences Company of the Year 2
(Date:12/26/2014)... (PRWEB) December 26, 2014 “Many people ... with personal injury claim issues and phone calls with ... released an article featuring their free eBook on ... helpful eBook on pedestrian and bicycle auto accident claims ... is fully capable of professionally handling their case while ...
(Date:12/25/2014)... The microscopy market is estimated ... reach $5,756.0 million by 2019. Optical microscopy is ... electron microscopes product segment is expected to show ... Rising focus on nanotechnology, technological advancements, and increasing ... market. , Get Full Copy of Report @ ...
(Date:12/25/2014)... New York (PRWEB) December 25, 2014 ... 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue ... reports. According to an Order issued in the U.S. ... the Court will convene an open conference on January ... and United States Courthouse in West Palm Beach, Florida. ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
(Date:12/25/2014)... Dennis Thompson HealthDay ... Very sick children with complex chronic illnesses can receive effective, ... "medical home," with easy access to a team of dedicated ... less likely to become seriously ill and need either hospitalization ... treatment at an enhanced medical home clinic at the University ...
Breaking Medicine News(10 mins):Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3
... Watch Policy against preparing for Bird flu epidemic may be ... taking intensified precautionary measures for curbing in case of a ... India to beef up // its precautionary measures to ... threat this winter from china due to spread from migratory ...
... Virginia Commonwealth University have found that increased levels of ... responsible for increasing the risk of heart disease in ... inflammation of the supporting tissue that surrounds the teeth. ... host of diseases including diabetes and cardiovascular disease. The ...
... funded survey indicates that the ageing population in Kerala which ... a day and most are non-vegetarians. ,Almost ... in Kerala eat three meals a day, according to ‘Kerala ... some interesting problem with the health of the elderly population. ...
... facing a new threat of bird flu panic fallowing ... ministry is undergoing tests for isolating// and identification of ... were no earlier reports on isolation of the virulent ... are confident that the strain is not spread from ...
... says that squinting at your computer screens is bad for the ... to eye strain, irritation and tearing // . Researchers at the ... they put themselves at risk for dry eye. ,"People ... display, and that squinting makes the blink rate go way down," ...
... in the December 1, 2005, issue of the International ... of radiation therapy // and chemotherapy could ... ,The journal, which is the official publication ... (ASTRO), adds that this combination approach is better than ...
Cached Medicine News:Health News:Severe Gum Disease Triples Heart Disease Risk 2Health News:Three meals daily Keeps 'Kerala's elderly Healthy 2Health News:Radiation And Chemotherapy, A Better Option For Head And Neck Cancer 2
ISI Self-Supporting Arm Table offers the easy accessibility for surgeons, technicians and equipment during upper extremity surgeries....
MagPrep® Streptavidin Beads are encapsulated super-paramagnetic polystyrol particles coated with streptavidin. The beads have a diameter of 1 m and are provided as a stabilized aqueous suspensio...
BioVintages Biotin-Trapper™ Streptavidin Magnetic Beads (1 mm - 2 mm) are designed for single-step capture of biotinylated molecules such as DNA, RNA or protein from cell lysates or hybridizatio...
QuantumPlex is a bead kit for multiple analyte-detection research applications in flow cytometry. The beads may be analyzed with any standard cytometer and do not require the use of specialized softw...
Medicine Products: