Navigation Links
Data Support use of SuperGen's CLIMB Technology in Lead Development and Optimization
Date:10/25/2007

Proprietary technology identifies small molecule JAK2 and Pim kinase

inhibitors

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced data as part of a series of presentations at the 2007 AACR-NCI-EORTC International Conference that describe how its proprietary CLIMB technology was used in lead development and design of small molecule JAK2 and Pim kinase inhibitors (Posters C200 and C208).

Poster C200 (Abstract No. 907)

Effect of small molecule inhibitors of JAK2 kinase on modulating signaling cascades downstream of cytokine receptors

Janus kinases (JAKs) are critical to a number of intracellular signaling pathways. Dysregulation of JAK2 signaling has been implicated in myoproliferative disorders, leukemia, lymphoma and various solid tumors. Utilizing CLIMB, SuperGen's proprietary technology, scientists used a JAK2 crystal structure to build several models that were made into a substrate for screening a large, virtual small molecule library. This process generated a subset of leads that were screened using in silico algorithms to identify "druggable" candidates to pursue.

Poster C208 (Abstract No. 985)

A small molecule inhibitor of Pim-1 kinase with activity in both hematological and solid tumor malignancies

Pim-1 kinase is involved in signaling pathways as a potent inhibitor of programmed cell death (apoptosis). Pim-1 is over expressed in many cancer types, including AML, CML, bladder and oral cancers. Scientists used SuperGen's CLIMB technology to build a model that allowed for the prediction of small molecule inhibitors. Leads were screened to identify those with inhibitory activity with low nanomolar IC50 concentrations. Data support further development of the lead compounds in liquid a
'/>"/>

SOURCE SuperGen Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
2. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
3. Pharmacyclics Announces Interim Results From Two Ongoing Phase 2 Trials Supporting Potential of Xcytrin Plus Chemotherapy to Treat Recurrent Non-Small Cell Lung Cancer
4. Infertile Voice Supports Stem Cell Research: RESOLVE Calls for Patient Options in Using Frozen Embryos
5. President Bush Ignores Americas Plea for Support of Stem Cell Research
6. Vastox Awarded £400,000 Grant to Support R&D at Carbohydrate Chemistry Facility
7. Diabetes drug supported by Mexican Diabetes Federation
8. Data Showing that ReGens Colostrinin Supports Healthy Cognitive Function Presented at the 2007 International Congress on Natural Medicine in Australia
9. Newly Published Data from Large Study Support Cardiovascular Safety of Avandia (Rosiglitazone Maleate)
10. Investigation Findings, Corroborated by Empirical Evidence of the Schisandra Berry as Cardio-Tonic in Traditional Chinese Medicine for Hundreds of Years, Support the Use of Schisandrin B in the Prevention and Treatment of IHD
11. Independent publication supports the profile of CeNeS phase II compound, CNS 5161
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Jan. 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, ... the Journal of Drugs in Dermatology (JDD) ... (ODAC). The event is January 17-20, 2014, at the Omni Orlando ... The ODAC is a distinguished event ...
(Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... Drug Forecast and Market Analysis to 2022 ... PharmaPoint: Atopic Dermatitis - India Drug Forecast ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5
(Date:7/9/2014)... the Perelman School of Medicine at the University of ... have received an $8 million grant from the National ... light therapy (PDT) in patients with malignant pleural mesothelioma, ... manifests itself in the lining of the lungs and ... grant will fund a clinical trial and additional studies ...
(Date:7/9/2014)... metabolism of stromal support cells and immune cells ... types in the development of diseases could open ... That was the conclusion of a review article by ... journal Nature . , Prof. Peter Carmeliet: "Consider ... metabolism of cancer cells has been examined in minute ...
(Date:7/9/2014)... personal and subjective, the human brain turns them ... across different senses, situations and even people, reports ... Anderson. , "We discovered that fine-grained patterns of ... of the brain associated with emotional processing, act ... subjective feeling," says Anderson, associate professor of human ...
(Date:7/9/2014)... for more than watching World Cup highlights, Brian Williams ... landing in unfortunate positions on railings. A University of ... Online Journal shows that YouTube also allows researchers, ... public on topics of skin cancer and prevention. , ... the future of how we communicate around the world," ...
(Date:7/9/2014)... labels handed out by pharmacists may be misread ... according to new research by the University of ... Blind)., The study, published recently in the ... prescription medications dispensed by pharmacies do not consistently ... simply following recommended guidelines for font size, use ...
Breaking Medicine News(10 mins):Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Wake-up call for more research into cell metabolism 2Health News:Study cracks how the brain processes emotions 2Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... conference organized in London by the Breast Cancer Campaign charity ... killer disease. //Instead it may become a long-term manageable disorder ... breast cancer patients has increased due to the significant developments ... revealed at the conference that the recurrence of the cancer ...
... with medical consultations and patients are seen tapping the ... medial ailments, especially ones they would like to hide ... infections scored very high on the search list and ... share of attention.NHS direct, the helpline is known to ...
... treatment was potentially beneficial in slowing and preventing ... (AMD). A recent study, the Complications of Age-Related ... from the National Eye Institute (NEI) of the ... laser treatment is ineffective in preventing complications of ...
... A recent research has found that more stress can lead ... restrain the cancer. //, ,A remarkable finding suggests that ... growth of cancer. Norepinephrine, a hormone released during stress stimulates ... tissue around tumor cells. This enables the cells to move ...
... a drug commonly prescribed to treat seizures and migraine ... stones//, researchers at UT Southwestern Medical Center have found. ... how the long-term use of topiramate affects kidney-stone formation ... Journal of Kidney Diseases. ,Several case reports ...
... major depression can become symptom-free if they are willing ... to determine which work best for them, which may ... the mix. ,The largest study on treatments for ... 67 percent of patients achieved a full remission of ...
Cached Medicine News:Health News:Breast Cancer may no longer be a killer disease 2Health News:People with early AMD not benefited by Laser Treatment 2Health News:More Stress, More Cancer 2Health News:More Stress, More Cancer 3Health News:Drug Prescribed for Migraines and Seizures Increases Risk of Kidney Stones 2Health News:Drug Prescribed for Migraines and Seizures Increases Risk of Kidney Stones 3Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 2Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 3
Sabre 180, 230V, 50Hz is a powerful niche generator....
High performance capabilities in a multipurpose generator, blended cut modes, simultaneous independent coagulation, low voltage coagulation, valleylab REM safety substantially reduces the risk of pat...
Lorgnette pinhole occluder...
Black multi-pinhole occluder...
Medicine Products: