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Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis
Date:9/5/2008

VIENNA, Va., Sept. 5 /PRNewswire-FirstCall/ -- CEL-SCI Corporation (Amex: CVM) announced today that it presented new rheumatoid arthritis data at the Marcus Evans conference on Immunogenicity in Amsterdam. The data, presented by Dr. Daniel Zimmerman, Senior Vice President of Research, Cellular Immunology of CEL-SCI, indicate that CEL-SCI's rheumatoid arthritis vaccine CEL-2000 prevents or retards the permanent tissue damage caused by rheumatoid arthritis in an animal model of the disease. These new findings further support previous positive results announced for this vaccine in June 2008. The data were derived from a histopathological analysis of tissues samples collected in comparative studies of CEL-2000 and Enbrel(R) that were conducted in a well established animal model of rheumatoid arthritis. Enbrel is a leading treatment for people with rheumatoid arthritis.

In the studies, the mice were injected with collagen on days 0 and 21 to induce the disease. Once the mice reached a significant and uniform disease state, therapy with Enbrel or CEL-2000 was initiated and continued for 28 days. CEL-2000 was administered only twice and Enbrel was administered either every day for the first 14 days (for the histopathology and immunology studies) or every other day over the entire study period of 28 days (for the immunology studies only).

Dr. Zimmerman reported previously that in studies conducted in mice treated similarly, CEL-2000 was equivalent or possibly superior to Enbrel in slowing disease progression and lessening symptoms. The new data presented today indicate that, in mice vaccinated with CEL-2000 after appearance of visible disease, statistically significant less inflammation and permanent damage with regard to 1) bone ero
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SOURCE CEL-SCI Corporation
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