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Data Show FLECTOR(R) Patch Yields Significant Pain Reduction for Acute Strains, Sprains and Contusions
Date:5/8/2008

CTOR(R) Patch results in minimal systemic absorption of diclofenac, one of the best selling and most widely used orally administered NSAIDs worldwide."

Acute pain is a common problem, with one in four adult Americans suffering an episode of pain lasting longer than 24 hours.(1)

Efficacy and Tolerability of FLECTOR(R) Patch in the Treatment of Minor Soft Tissue Injury Pain (Abstract #8332/Poster #278)(2)

The efficacy and tolerability of FLECTOR(R) Patch was evaluated in a randomized, double-blind, placebo-controlled, parallel-group trial of 418 patients, aged 18-65 years who rated the minor soft tissue injuries they sustained within seven days of study entry as having a pain intensity of greater than or equal to five on a zero to 10 scale. Patients self-administered FLECTOR(R) Patch every 12 hours to the injury site. The primary study outcome was post-treatment pain, expressed as a proportion of the baseline pain score, which was recorded on a visual analog scale of zero to 10 in a diary, twice-daily for 14 days, or until pain resolution. The secondary study outcomes included end-of-treatment Investigator Global Assessment of Response to Therapy (a five-point scale, "none" to "excellent"), and time to pain resolution (four scores less than or equal to two).

Patients treated with FLECTOR(R) Patch experienced improved mean pain scores (40.4 percent of baseline score) versus patients using placebo patch (47.4 percent, p<0.05); overall pain reduction was 14.8 percent. FLECTOR(R) Patch patients also reached pain resolution three days sooner than those in the placebo patch group (median, 10.0 versus 13.5 days, p=0.01). Additionally, at the conclusion of the study, the Investigator Global Assessment of Response to Therapy significantly favored the FLECTOR(R) Patch: patient response to treatment was rated "good" to "excellent" for 57.8 percent of FLECTOR(R) Patch patients, versus 48.4 percent of placebo patch patients, and a "no"/"poor" response w
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SOURCE Alpharma Inc.
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