Navigation Links
Data Show Aerovance's Aerovant(TM) Inhalation Powder is Well Tolerated in Asthma Patients
Date:10/7/2008

BERKELEY, Calif., Oct. 7 /PRNewswire/ -- Aerovance Inc. today reported pharmacokinetic (PK) and safety data from a Phase I trial of its Aerovant inhalation powder that demonstrate good tolerability with no evidence of local irritancy following asthma patients' inhalation of a single 10 mg dose.

This 10 mg dose will be the highest of three doses investigated in Aerovance's Phase IIb dose-ranging study, which is scheduled to begin early next year. Evidence gathered from nonclinical and clinical studies indicates the primary action of Aerovant is local to the lung, while the PK data confirm that the dry powder inhaler achieved the targeted lung dose. The data were presented by E. Burmeister Getz, Ph.D, at the European Respiratory Society (ERS) Annual Congress in Berlin.

"We are encouraged by the PK and safety data that demonstrate Aerovant's potential for treating uncontrolled asthma when delivered as an inhalation powder," said Mark Perry, Aerovance's president and chief executive officer. "The conclusions presented, along with our efficacy and safety data from previous clinical studies, validate the benefits of delivering Aerovant directly to the lung. Similar to the most widely used asthma medications, Aerovant will be delivered as a dry powder, a method of administration that doctors and asthma patients have embraced."

Ten subjects with mild-to-moderate asthma participated in the study and were administered a single 10 mg dose of Aerovant inhalation powder via the EZ Aer(TM) Inhaler. Serial measurements of PK and lung function (FEV1) were collected over a 24-hour period post dosing. Results indicated that time to peak blood concentration was two hours, in agreement with nebulization of 60 mg Aerovant solution. Half-life in the blood, three hours, was similarly unaffected by formulation and dose level. Using blood concentrations as a surrogate measure of lung dose, the PK data estimate a 3.2-mg dose to the lung was achieved, thus hitting
'/>"/>

SOURCE Aerovance Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. PARIs eFlow Included in Gileads NDA Submission for Aztreonam Lysine for Inhalation
2. Data from Three Clinical Trials for Perforomist(TM) Inhalation Solution to be Presented at CHEST 2007 on October 24, 2007
3. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
4. IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients
5. Novel Xeloda(R) Dosing Schedule May Offer Well-Tolerated Alternative for Treatment of Advanced Breast Cancer
6. Data Presented at AAN Show That Lacosamide Significantly Reduced Pain and was Generally Well Tolerated in Patients With Diabetic Neuropathic Pain
7. Update From Mipomersen Extended Dosing Study Continues to Show That Mipomersen Is Well Tolerated and Maintains Activity in Patients Treated for Up to 16 Months
8. Multiple Dose Clinical Trial of TorreyPines Therapeutics Tezampanel Demonstrates Compound is Safe and Well-Tolerated
9. IDM Pharma Announces IDM-2101 Updated Phase 2 Results Show Treatment Well Tolerated With Positive Survival Trend in Lung Cancer Patients
10. Study Shows VAPRISOL(R) is Effective in Increasing Serum Sodium Levels and Well-Tolerated in Patients With Euvolemic or Hypervolemic Hyponatremia
11. Neupro(R) (Rotigotine Transdermal System) Effective in Controlling Early Morning Motor Impairment and Generally Well-Tolerated for Long-Term Use in Patients with Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... SHANGHAI , Oct. 22, 2014 /PRNewswire/ ... FMI ) and WuXi PharmaTech (Cayman) Inc. (NYSE: ... Foundation Medicine,s comprehensive genomic profiling to biopharmaceutical companies conducting ... Under the terms of the collaboration, Foundation ... laboratory component of Foundation Medicine,s FoundationOne® assay at the ...
(Date:10/20/2014)... 2014  Luoxis Diagnostics, Inc., a subsidiary of ... that its academic collaborators will present several peer-reviewed ... its novel RedoxSYS Diagnostic System, a first-in-class platform ... in response to injury or illness.  A poster ... clinical marker will be presented by Christopher ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
Breaking Medicine Technology:Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 2Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 3Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 4Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
(Date:10/22/2014)... For Dr. Iris Hunter, a job is more ... of her life’s mission. Her extensive experience in the nonprofit ... FirstLight HomeCare, make it clear that Hunter’s mission is to ... work makes a difference in the lives of others,” Hunter ... much research, I felt ready to start on this journey ...
(Date:10/22/2014)... Lexington, Kentucky (PRWEB) October 22, 2014 ... an agreement that will change the current location of ... Road to South Limestone across from the University of ... be a state-of-the-art ambulatory care center, owned and operated ... meet the orthopaedic needs of children and their families ...
(Date:10/22/2014)... With the Affordable Care Act (ACA) open ... American Institutes for Research (AIR) finds that three out of ... insurance, but 42 percent say they are not likely or ... up for coverage. , The AIR survey found wide gaps ... to calculate correctly how much they owe for a routine ...
(Date:10/22/2014)... Healthcare professionals who are looking for ... home or on-the-go via laptops, tablets or mobile ... premium Seminar-on-Demand CE courses. The new courses add ... hours of CE course offerings, allowing therapy ... such a diverse library, there’s something for everyone. ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Lintelus, Inc., ... Sr. Vice President of Sales, will be speaking on ... Meetings Technology Expo on October 28, at the Holiday ... hosting a booth as well as a Tech Demo ... Meeting can create a more engaging event experience. , ...
Breaking Medicine News(10 mins):Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2
... , MIAMI, Dec. 7 A ... sent parents searching frantically for gifts made in the USA. ... so-called educational toys are suspect. Renowned parenting expert Dr. Jeffrey ... developing brains, retarding language development and shortening attention spans. Moreover, ...
... ... – the internet’s first, social networking community developed by, and dedicated to, persons with ... with others of like minds, circumstances and situations while maintaining as much, or as ... ...
... 7 The National Health Service (NHS), which manages 500 ... the value of an engaged staff: healthier and happier patients. ... of care, many NHS hospitals are teaming up with international ... leaders. , "Staff engagement is essential to meeting the financial ...
... , WEST PALM BEACH, Fla., Dec. 7 The Cubicle ... to publicize the first major innovation in hospital privacy curtains ... already saving hospitals millions in maintenance costs. , TransMedia ... to elevate Cubicle Curtain Factory,s profile in print, broadcast, online ...
... , BOCA RATON, Fla., Dec. 7 With more ... and homeopathic remedies for people and their pets, Native Remedies, ... The company,s two brands, Native Remedies ( www.nativeremedies.com ) and ... guaranteed products that promote health and wellness - naturally. ...
... ... health care costs is the neglect to use low-tech strategies to prevent ... after it has arisen," reports a groundbreaking review in the November 2009 ... Mindfulness Meditation can improve health and wellbeing by: ameliorating pain, decreasing stress ...
Cached Medicine News:Health News:Top 10 Toys That Will Scar Your Child for Life 2Health News:Social Networking Community Reaches Out to Persons With Illnesses and Disabilities 2Health News:Social Networking Community Reaches Out to Persons With Illnesses and Disabilities 3Health News:Social Networking Community Reaches Out to Persons With Illnesses and Disabilities 4Health News:The NHS to Improve Patient Care by Better Engaging Staff 2Health News:Cubicle Curtain Factory Retains TransMedia Group to Promote First Privacy Curtain to Reduce Hospital Maintenance Cost 2Health News:Native Remedies and PetAlive.com Hires TransMedia Group to Herald Herbal for People and Pets 2Health News:The Role of Mindfulness Meditation in Health Care Reform 2Health News:The Role of Mindfulness Meditation in Health Care Reform 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: