Navigation Links
Data Show Aerovance's Aerovant(TM) Inhalation Powder is Well Tolerated in Asthma Patients
Date:10/7/2008

BERKELEY, Calif., Oct. 7 /PRNewswire/ -- Aerovance Inc. today reported pharmacokinetic (PK) and safety data from a Phase I trial of its Aerovant inhalation powder that demonstrate good tolerability with no evidence of local irritancy following asthma patients' inhalation of a single 10 mg dose.

This 10 mg dose will be the highest of three doses investigated in Aerovance's Phase IIb dose-ranging study, which is scheduled to begin early next year. Evidence gathered from nonclinical and clinical studies indicates the primary action of Aerovant is local to the lung, while the PK data confirm that the dry powder inhaler achieved the targeted lung dose. The data were presented by E. Burmeister Getz, Ph.D, at the European Respiratory Society (ERS) Annual Congress in Berlin.

"We are encouraged by the PK and safety data that demonstrate Aerovant's potential for treating uncontrolled asthma when delivered as an inhalation powder," said Mark Perry, Aerovance's president and chief executive officer. "The conclusions presented, along with our efficacy and safety data from previous clinical studies, validate the benefits of delivering Aerovant directly to the lung. Similar to the most widely used asthma medications, Aerovant will be delivered as a dry powder, a method of administration that doctors and asthma patients have embraced."

Ten subjects with mild-to-moderate asthma participated in the study and were administered a single 10 mg dose of Aerovant inhalation powder via the EZ Aer(TM) Inhaler. Serial measurements of PK and lung function (FEV1) were collected over a 24-hour period post dosing. Results indicated that time to peak blood concentration was two hours, in agreement with nebulization of 60 mg Aerovant solution. Half-life in the blood, three hours, was similarly unaffected by formulation and dose level. Using blood concentrations as a surrogate measure of lung dose, the PK data estimate a 3.2-mg dose to the lung was achieved, thus hitting
'/>"/>

SOURCE Aerovance Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. PARIs eFlow Included in Gileads NDA Submission for Aztreonam Lysine for Inhalation
2. Data from Three Clinical Trials for Perforomist(TM) Inhalation Solution to be Presented at CHEST 2007 on October 24, 2007
3. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
4. IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients
5. Novel Xeloda(R) Dosing Schedule May Offer Well-Tolerated Alternative for Treatment of Advanced Breast Cancer
6. Data Presented at AAN Show That Lacosamide Significantly Reduced Pain and was Generally Well Tolerated in Patients With Diabetic Neuropathic Pain
7. Update From Mipomersen Extended Dosing Study Continues to Show That Mipomersen Is Well Tolerated and Maintains Activity in Patients Treated for Up to 16 Months
8. Multiple Dose Clinical Trial of TorreyPines Therapeutics Tezampanel Demonstrates Compound is Safe and Well-Tolerated
9. IDM Pharma Announces IDM-2101 Updated Phase 2 Results Show Treatment Well Tolerated With Positive Survival Trend in Lung Cancer Patients
10. Study Shows VAPRISOL(R) is Effective in Increasing Serum Sodium Levels and Well-Tolerated in Patients With Euvolemic or Hypervolemic Hyponatremia
11. Neupro(R) (Rotigotine Transdermal System) Effective in Controlling Early Morning Motor Impairment and Generally Well-Tolerated for Long-Term Use in Patients with Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... FAIRFAX, Va. , Aug. 21, 2014 /PRNewswire/ ... real-time quality and Manufacturing Intelligence , today ... Intelligence Conference. The event will be held Oct. ... Mile, and is designed to showcase the necessity ... use of metrics and Manufacturing Intelligence to gain ...
(Date:8/21/2014)... 2014 CVS Caremark Corporation (NYSE: CVS ... and consideration payable in connection with its previously announced cash ... for (1) any and all of its 6.250% Senior Notes ... to a maximum amount of its 6.125% Senior Notes due ... due 2017 (collectively, the "Maximum Tender Offer Notes" and together ...
(Date:8/21/2014)... TORONTO , Aug. 21, 2014 /CNW/ - Bedrocan ... appointed three independent members to its Board of ... care experience of the company, a leading licensed ... . Internationally, Bedrocan has 13 years, experience ... patients in seven countries, including Canada. ...
Breaking Medicine Technology:InfinityQS to Host Manufacturing Intelligence Conference in Chicago 2CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 2CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 3CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 4CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 5CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 6Senior Life Sciences Executives Join Bedrocan as Independent Directors 2Senior Life Sciences Executives Join Bedrocan as Independent Directors 3
... SKILLMAN, N.J., Oct. 1 The Great Comebacks® ... Celebrating its 25th anniversary this year, the ... of adults and young people who have overcome ... , The awards are sponsored by ConvaTec, a ...
... Oct. 1 Echo Therapeutics, Inc. (OTC Bulletin Board: ... needle-free Symphony(TM) tCGM System as a non-invasive, wireless, transdermal ... System for transdermal drug delivery, announced today that Patrick ... present at the 4th Annual JMP Securities Healthcare Conference ...
Cached Medicine Technology:The Great Comebacks(R) Program Announces 2009 Regional Awards Recipients 2The Great Comebacks(R) Program Announces 2009 Regional Awards Recipients 3The Great Comebacks(R) Program Announces 2009 Regional Awards Recipients 4Echo Therapeutics to Present at 4th Annual JMP Securities Healthcare Conference 2
(Date:8/21/2014)... August 21, 2014 Pulmonary Hypertension ... an Education Forum for PH patients and families ... Pulmonary Hypertension Association – the country’s ... ways to prevent and cure pulmonary hypertension (PH) ... the functioning of the heart and can lead ...
(Date:8/21/2014)... August 21, 2014 The City of ... for entertainment and programming for its inaugural “Re:Imagine Garden ... October 12, 2014, from 11 a.m. to 4 p.m., ... all cars and the downtown will be filled with ... by Community Arts Resources (CARS), for all to enjoy. ...
(Date:8/21/2014)... Dennis Thompson HealthDay Reporter ... A combination of therapy and antidepressants appears to best ... study reports. Four out of five people suffering ... full recovery when treated with cognitive therapy plus antidepressant ... combination didn,t work much better than drugs alone in ...
(Date:8/21/2014)... is to focus on her body in terms of ... her as a complete human being with thoughts and ... in the media, how does it affect individual romantic ... Quarterly , a SAGE journal, finds that more objectification ... incidents of sexual pressure and coercion., Researchers Laura R. ...
(Date:8/21/2014)... The world wound care market is expected ... reach USD 18.3 billion by 2019, posting a CAGR ... such growth include governments’ contribution to the development of ... surging ageing population. However, the growth could be restrained ... North America leads the global wound care market, with ...
Breaking Medicine News(10 mins):Health News:Pulmonary Hypertension Association Goes On the Road to Houston With an Education Forum for PH Patients and Families to Help Fight Rare Lung Disease 2Health News:Pulmonary Hypertension Association Goes On the Road to Houston With an Education Forum for PH Patients and Families to Help Fight Rare Lung Disease 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 4Health News:Talk Therapy Plus Meds May Be Best for Severe Depression 2Health News:Talk Therapy Plus Meds May Be Best for Severe Depression 3Health News:Objectification in romantic relationships related to sexual pressure and coercion 2Health News:Global Wound Care Market to Post 3.2% CAGR Through 2019, Says MarketsandMarkets in Its New Report Published at MarketPublishers.com 2Health News:Global Wound Care Market to Post 3.2% CAGR Through 2019, Says MarketsandMarkets in Its New Report Published at MarketPublishers.com 3
... from the United Kingdom cured well-established prostate tumors in ... effects. This novel cancer treatment approach encourages the immune ... from toxic chemotherapies and radiation treatments. Such a treatment ... free with fewer side effects than those experienced from ...
... , SATURDAY, June 18 (HealthDay News) -- Whether they ... should never be in close proximity to a running lawn ... a running lawn mower. And children under the age of ... lawn mower or walk-behind mower," Dr. Edwin Harris, pediatric podiatrist ...
... News) -- Last year, more people died than were born ... shows. This trend, known as natural decrease, is the ... in fertility levels. Researchers from the Carsey Institute at the ... are particularly hard hit by natural population decrease, which is ...
... The first three patients to undergo an investigational surgical ... own stem cells continue to do well, reports the ... The "TGI-PVG IDE" clinical trial initiated at UofL ... man-made bypass grafts to better the chances at saving ...
... , FRIDAY, June 17 (HealthDay News) -- ... reveals that doctors may overprescribe antibiotics to patients receiving ... McMaster University in Ontario, Canada, found that patients younger ... are at greatest risk for misuse of the drugs. ...
... News) -- Foster care boosts language development in young children ... looked at more than 100 children who had lived in ... in foster homes when they were about 22 months old, ... groups were compared to about 60 young children who lived ...
Cached Medicine News:Health News:Mayo Clinic researchers use human vaccine to cure prostate cancer in mice 2Health News:Adults Reminded to Keep Kids Away From Lawn Mowers 2Health News:Deaths Exceed Births in 24% of U.S. Communities: Report 2Health News:University of Louisville surgeons perform first prosthetic bypass graft with patient's stem cells at point-of-care 2Health News:University of Louisville surgeons perform first prosthetic bypass graft with patient's stem cells at point-of-care 3Health News:University of Louisville surgeons perform first prosthetic bypass graft with patient's stem cells at point-of-care 4Health News:Docs Overprescribing Antibiotics for Home-Care Patients: Study 2Health News:Language Delays Seen in Kids in Institutions Beyond Age 2 2
... the ProtecPoint Exit Alerting System, instantly ... and assets (e.g. medical equipment), with ... facility. With this form of exit ... savings, operating efficiencies, and overall peace ...
... Context-sensitive medicine is the ability of ... in pre-determined ways based on what is ... the associations a Radianse indoor positioning solution ... and it requires identity, location and time ...
... ability to track the movement of ... assets can be done. VerdaSee's "intellishelvess" ... Continuous cycle counting is possible with ... (RFID) technology makes this possible. VerdaSee ...
Agility has delivered a RFID-enabled mobile asset management program....
Medicine Products: