Navigation Links
Data Published in the New England Journal of Medicine for Vedolizumab, an Investigational New Drug from Takeda for Moderately to Severely Active Ulcerative Colitis and Crohn's Disease
Date:8/21/2013

ocorticoid-free remission was seen in 31.7 percent and 28.8 percent of patients taking oral glucocorticoids at baseline randomized, respectively, to vedolizumab every eight weeks or every four weeks versus 15.9 percent of patients receiving placebo at week 52 (p=0.02, p=0.04, respectively).

The safety population in GEMINI II comprised 1,115 patients for weeks 0-52. The most common adverse events reported in the 814-patient vedolizumab arm (˃8.0 percent) were Crohn's disease exacerbation, arthralgia, pyrexia, nasopharyngitis, headache, nausea and abdominal pain. The most common adverse events reported in the 301-patient placebo arm (greater than or equal to 8.0 percent) were Crohn's disease exacerbation, headache, arthralgia, pyrexia, abdominal pain, nausea, and nasopharyngitis. Five deaths occurred during the study period, four among patients receiving vedolizumab (one death each from Crohn's disease with sepsis, intentional overdose of prescription medication, myocarditis, and septic shock) and one in the placebo group (from bronchopneumonia).

About the GEMINI™ Studies          
Announced in early 2009, the GEMINI Studies™ is a Phase 3 program evaluating the effect of vedolizumab on clinical response and remission (along with effect on mucosal healing in UC), and long-term safety in moderately to severely active CD and UC patients who had failed at least one conventional therapy or a TNFalpha antagonist. The GEMINI program consists of four separate studies – a placebo-controlled induction and maintenance study in patients with UC (GEMINI I), a placebo-controlled induction and maintenance study in patients with CD (GEMINI II), a placebo-controlled induction study in patients with CD (GEMINI III) and an open-label long-term safety study in patients with either CD or UC (GEMINI LTS).

About Crohn's disease and ulcerative colitis
Crohn's disease (CD) and ul
'/>"/>

SOURCE Takeda Pharmaceutical Company Limited
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. 1st Case Report of Using Single-Site Cannulation ECMO to Treat SynCardia Total Artificial Heart Patient Published in Journal of Cardiothoracic Surgery
2. Mechanism for Cardiac Effects of Trevena Angiotensin Receptor Biased Ligands Examined in Published Study
3. Leadership Through Research Collaboration Is Reflected In Articles Published In Alzheimers Association Journal
4. Depression Study Published on BCM-95 Curcumin
5. Ibrutinib Phase 2 Study Results in Patients with Mantle Cell Lymphoma Published in The New England Journal of Medicine
6. Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine
7. BioElectronics New Patent Published
8. Benefits of Using Hologics Breast Tomosynthesis Mammography Technology Supported in Published Italian Study
9. Clinical Results for Orameds Oral Diabetes Treatment Published in Peer Reviewed Journal PLOS ONE
10. Study Published in European Radiology Further Supports the Use of Hologics Breast Tomosynthesis in Cancer Screening in Practices Using Double Reads
11. Data on SEEKs Novel Immunotherapy for HIV Published in Virology Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... -- Research and Markets ( ... "The New Trends of Global Preclinical Development ... The report, The New Trends of Global ... the current development states and the future growth ... The report is designed to reveal the latest ...
(Date:7/7/2015)... 2015  The Arentz Law Group is currently investigating cases ... .  Women who have taken Zyban while pregnant, and given ... encouraged to contact the law firm immediately for a ... in the American Journal of Obstetrics & Gynecology  showed ... risk of giving birth to a child with " left ...
(Date:7/7/2015)... NEWTOWN, Pennsylvania , 7. Juli 2015 /PRNewswire/ ... Spezial-Dienstleistungen und -Technik für klinische Studien, gab heute ... (Medici) ein führendes Unternehmen bei Gewinnung und Erhalt ... umfasst die Tochtergesellschaften MediciGlobal , Ltd. und ... L2FU® auch einen Dienst zum Auffinden von ...
Breaking Medicine Technology:New Trends in the 2015 Global Preclinical Development Outsourcing Market 2New Trends in the 2015 Global Preclinical Development Outsourcing Market 3New Trends in the 2015 Global Preclinical Development Outsourcing Market 4New Trends in the 2015 Global Preclinical Development Outsourcing Market 5Smoking cessation drug linked to birth defects when taken during pregnancy 2BioClinica übernimmt MediciGroup 2BioClinica übernimmt MediciGroup 3BioClinica übernimmt MediciGroup 4
... is the number one cause of all recent agents ... to 74 years of age, according to Transitions Optical,s ... diagnosed by a primary healthcare provider like an internist, ... the ocular signs of the disease. ...
... Nov. 17, 2010 Reportlinker.com announces that a new ... European Markets for Wound and Tissue Management ... In 2009, the total European wound and tissue management ... European markets for wound and tissue management covers 15 ...
Cached Medicine Technology:The Truth About Diabetes and Visual Complications Unveiled 2The Truth About Diabetes and Visual Complications Unveiled 3Reportlinker Adds European Markets for Wound and Tissue Management 2011 2Reportlinker Adds European Markets for Wound and Tissue Management 2011 3Reportlinker Adds European Markets for Wound and Tissue Management 2011 4Reportlinker Adds European Markets for Wound and Tissue Management 2011 5Reportlinker Adds European Markets for Wound and Tissue Management 2011 6Reportlinker Adds European Markets for Wound and Tissue Management 2011 7Reportlinker Adds European Markets for Wound and Tissue Management 2011 8Reportlinker Adds European Markets for Wound and Tissue Management 2011 9Reportlinker Adds European Markets for Wound and Tissue Management 2011 10Reportlinker Adds European Markets for Wound and Tissue Management 2011 11Reportlinker Adds European Markets for Wound and Tissue Management 2011 12Reportlinker Adds European Markets for Wound and Tissue Management 2011 13Reportlinker Adds European Markets for Wound and Tissue Management 2011 14Reportlinker Adds European Markets for Wound and Tissue Management 2011 15Reportlinker Adds European Markets for Wound and Tissue Management 2011 16Reportlinker Adds European Markets for Wound and Tissue Management 2011 17Reportlinker Adds European Markets for Wound and Tissue Management 2011 18Reportlinker Adds European Markets for Wound and Tissue Management 2011 19Reportlinker Adds European Markets for Wound and Tissue Management 2011 20Reportlinker Adds European Markets for Wound and Tissue Management 2011 21Reportlinker Adds European Markets for Wound and Tissue Management 2011 22Reportlinker Adds European Markets for Wound and Tissue Management 2011 23
(Date:7/7/2015)... ... July 07, 2015 , ... This week Northeast ... brand new website. The website’s goal is to provide patients with detailed information ... tools, including requesting appointments online. , Part of the center’s rebranding efforts, the ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... two firms have merged to form Camber Collective. Camber Collective provides strategic ... merger combines SwitchPoint’s strategy consulting expertise with Hope Consulting’s deep experience in ...
(Date:7/7/2015)... ... July 07, 2015 , ... Greatist today ... website that helps active people find the most fun activities to do with friends. ... for millennials. It also increases Greatist’s opportunity for events, e-commerce, and brand partnerships. , ...
(Date:7/7/2015)... ... July 07, 2015 , ... Quadrino Law Group is pleased to announce ... New York 11747. The new facility is a state of the art building, ... Richard Quadrino, the firm's CEO and founder, said, "We are pleased to service our ...
(Date:7/7/2015)... ... , ... SC&H Group, a leading audit, tax, and consulting firm, recently hosted ... through company-wide volunteering efforts. , On an annual basis, in coordination with Business ... need throughout Baltimore and Washington D.C. , This year, SC&H Group’s team ...
Breaking Medicine News(10 mins):Health News:Northeast Nebraska Imaging Launches New Patient Friendly Website 2Health News:SwitchPoint and Hope Consulting Have Merged to Form Camber Collective 2Health News:Greatist Acquires Active Lifestyle Brand Blood, Sweat & Cheers 2Health News:SC&H Group Celebrates 9th Annual Day of Service 2
... --, LAKE FOREST, Ill., Feb. 28 Hospira, Inc.,(NYSE: ... reported results for the fourth quarter and full,year ended Dec. 31, ... percent to $946.1 million in the fourth ... last year. Net sales excluding Mayne Pharma ...
... Run Ads in Heavy Rotation Through Primary, ... of Ohio,s crucial,primary vote Tuesday, the National Nurses ... campaign across Ohio with,an emphatic message to the ... support real healthcare reform., The 60-second radio ...
... effective treatment for lowering cholesterol, are widely used ... large clinical trials. Although side effects are usually ... have been reported. Tendon impairment has been reported ... studies. A new study published in the March ...
... Thomson Research Award Ceremony Celebrates the Best in Australian ... Held at the National Press Club on 2 April, ... of The Thomson Corporation (NYSE: TOC ; TSX: ... research and business,communities, today announced it will honor Australia,s ...
... Actavis Group, the,international generic pharmaceuticals company, has ... Food & Drug Administration., The four products ... equivalent of,Bontril(R) tablets by Valeant Pharmaceuticals, are indicated ... of Phendimetrazine tartrate tablets,had annual sales of US$3.1 ...
... Pictures Television,International,s (SPTI) Latin American advertising sales group ... detection campaign in,support of Latin American women. The ... and SPTI,s powerful media,reach to assist Latin America ... is called "SER," which means "to be" in ...
Cached Medicine News:Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 2Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 3Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 4Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 5Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 6Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 7Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 8Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 9Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 10Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 11Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 12Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 13Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 14Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 15Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 16Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 17Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 18Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 19Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 20Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 21Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 22Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 23Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 24Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 25Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 26Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 27Health News:Hospira Reports Fourth-Quarter and Full-Year 2007 Results 28Health News:Nurses Launch Major Ohio Radio Ad Campaign Telling Candidates: Stop Selling Insurance and Back Real Reform 2Health News:Nurses Launch Major Ohio Radio Ad Campaign Telling Candidates: Stop Selling Insurance and Back Real Reform 3Health News:Tendon complications, though rare, linked to statins 2Health News:Thomson Scientific To Honor Australia's Top Researchers With Dedicated Australian Research Day 2Health News:Thomson Scientific To Honor Australia's Top Researchers With Dedicated Australian Research Day 3Health News:Actavis Extends Portfolio With Four New Products in the U.S. 2Health News:Novartis and Sony Pictures Television International's Latin American Advertising Sales Group Launch Partnership to Create Multi-Media Platform for Breast Cancer Awareness, Detection, and Treatment in Latin America 2Health News:Novartis and Sony Pictures Television International's Latin American Advertising Sales Group Launch Partnership to Create Multi-Media Platform for Breast Cancer Awareness, Detection, and Treatment in Latin America 3
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
... provide a broad selection of ... a wide variety of ophthalmic ... is packaged sterile, complete with ... switch in the "off " ...
... provide a broad selection of ... a wide variety of ophthalmic ... is packaged sterile, complete with ... switch in the "off " ...
Medicine Products: