Navigation Links
Data Published in the Journal of Interventional Cardiology Demonstrate Effectiveness and Safety of OrbusNeich's Genous™ Stent in Diabetic Patients
Date:3/23/2011

HONG KONG, March 23, 2011 /PRNewswire/ -- OrbusNeich today announced that 12-month outcomes data from a subset analysis of the global e-HEALING registry were published online ahead of print in the Journal of Interventional Cardiology and demonstrated the effectiveness and safety of the company's Genous Stent in diabetic patients, with low definite and probable stent thrombosis (ST) comparable to non-diabetics.

The study investigated the 1,236 diabetic patients from the e-HEALING registry, including 273 insulin requiring diabetics (IRD) and 963 non-insulin requiring diabetics (NIRD), and compared this cohort to the non-diabetic study participants.

The investigators found a target vessel failure (TVF) rate of 10 percent in diabetics, compared to 7.9 percent in non-diabetics. The TVF rates were 13.4 percent and 9 percent in IRD and NIRD, respectively. The higher TVF rates were driven mainly by a higher mortality hazard in both diabetic subgroups when compared to non-diabetics. The target lesion revascularization (TLR) rates were comparable in diabetics and non-diabetics, with 6.4 percent in diabetics versus 5.4 percent in non-diabetics. Definite or probable ST occurred in 1.1 percent of both diabetics and non-diabetics.

"Diabetics treated with percutaneous coronary intervention remain a high-risk subgroup," said Peter Damman, M.D., of the Academic Medical Center in Amsterdam and lead author of the paper. "These data show that Genous provides an effective alternative for managing thrombotic risk in this challenging group of patients."

The primary outcome for the e-HEALING registry was TVF at 12-month follow-up. TVF was defined as the composite of cardiac death or myocardial infarction (MI), unless unequivocally attributed to a non-target vessel, and target vessel revascularization (TVR).  

The median age of the diabetic cohort was 64 years, 73 percent were male, and the mean body mass index (BMI) was 28.3. In diabetics, an average of 1.4 lesions per patient was treated, with an average of 1.1 Genous Stents per lesion. Off all lesions, 10 percent were bifurcation lesions, 97 percent were de novo lesions, and 48 percent were type B2/C lesions.

Michael Kutryk, M.D., Ph.D., clinician scientist and an interventional cardiologist at St. Michael's Hospital, as well as an assistant professor at the University of Toronto, added, "Patients with cardiovascular risk factors, including diabetes, have a reduced number of circulating endothelial progenitor cells (EPCs) that is due to either a direct influence on the mobilization and half-life of the EPCs or to a depletion of these cells caused by continuous endothelial damage or dysfunction. Capturing circulating EPCs with the unique Genous technology promotes and restores the natural healing process that is impaired in diabetics."

About Genous

Genous is OrbusNeich's patented EPC capture technology that promotes the accelerated natural healing of the vessel wall after the implantation of blood-contact devices such as stents. The technology consists of an antibody surface coating that attracts EPCs circulating in the blood to the device to form an endothelial layer that provides protection against thrombosis and modulates restenosis.

The Genous Stent, which  has been commercially available in more than 60 countries since 2005, has been proven as a safe, effective alternative to drug-eluting stents and is supported by data from more than 5,000 patients in company-sponsored clinical studies. There is a growing body of evidence from multiple clinical studies that the Genous Stent is effective for patients who are non-responsive to or cannot tolerate long-term dual antiplatelet therapy.

About OrbusNeich

OrbusNeich is a global company that designs, develops, manufactures and markets innovative medical devices for the treatment of vascular diseases. Current products are the world's first pro-healing stent, the Genous Stent, as well as other stents and balloons marketed under the names of Azule™, R stent, Scoreflex™, Sapphire™, Sapphire II and Sapphire NC. Development stage products include the Combo™ Bio-engineered Sirolimus Eluting Stent, or Combo Stent, which combines the Genous pro-healing technology for rapid endothelial coverage with an abluminal sirolimus drug elution for the control of neointimal proliferation. OrbusNeich is headquartered in Hong Kong and has operations in Shenzhen, China; Fort Lauderdale, Fla.; Hoevelaken, The Netherlands; and Tokyo, Japan. OrbusNeich, which has provided medical devices to physicians through its predecessor companies since 1979, supplies products today to interventional cardiologists in more than 60 countries. For more information, visit www.OrbusNeich.com.  Follow OrbusNeich on Twitter at www.twitter.com/OrbusNeich.


'/>"/>
SOURCE OrbusNeich
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Positive Findings From Excellagen Matrix Clinical Study Published in Peer-Reviewed Journal Wound Repair and Regeneration
2. German High Court Rules in Favor of AmniSure® as New European Guidelines Published
3. Results Published in The Lancet Demonstrate Superiority of XGEVA™ (Denosumab) in the Prevention of Bone Complications for Men With Bone Metastases From Advanced Prostate Cancer
4. Analysis of Calipers Phase I EPA ToxCast™ Data Published in Leading Scientific Journal
5. Published Data From e-HEALING Registry Demonstrate Good Clinical Outcomes With Low Incidence of Repeat Revascularization and Stent Thrombosis for OrbusNeichs Genous™ Stent
6. Caldolor® Rapid Infusion Shown to be Safe and Well Tolerated in Newly Published Clinical Study
7. CHAMPION Study Published in The Lancet
8. Data on DermTechs Non-invasive Test for Melanoma Are Published in the British Journal of Dermatology
9. New Published Study Finds Noninvasive Masimo PVI Accurately Predicts Fluid Responsiveness in Intensive Care Patients
10. Newly Published Data Demonstrates Caldolor® Significantly Reduces Pain and Morphine Use in Post-Operative Patients
11. First Five-Year Outcomes Published on CyberKnife Radiosurgery for Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/7/2017)...  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... it will be participating in the Morgan Stanley 15 ... Hyatt hotel in New York.  Zimmer Biomet will present ... Time. A live webcast of the presentation ... at http://investor.zimmerbiomet.com .   ...
(Date:9/6/2017)... --  PDI , a leader in infection prevention products ... session focused on the role of chlorhexidine gluconate (CHG) ... 2017 Annual Scientific Meeting of the Association for Vascular ... Phoenix Convention Center in ... also feature PDI,s Prevantics® Device Swab as ...
(Date:9/5/2017)... Inc. has announced another milestone in their continued growth and success of the ... demands of customer engagements regionally.  ... office is located at 318 West Adams Street, Suite 1528, Chicago, IL ... Xyntek's recently opened Midwest office ... In addition ...
Breaking Medicine Technology:
(Date:9/19/2017)... ... September 19, 2017 , ... The Workgroup for ... health IT to create efficiencies in healthcare information exchange and a trusted advisor to ... their latest industry white paper, entitled Barriers to Adoption of the ERA and ...
(Date:9/19/2017)... ... September 19, 2017 , ... Big ... recognized for its September 2016 donation of dog beds to the K9 officers ... awards and honors for its contribution from city and state officials. , ...
(Date:9/19/2017)... , ... September 19, 2017 , ... Driving Dynamics Inc., ... Training Company by Training Industry Inc. as part of its mission to continually monitor ... Selection to the first annual 2017 Top 20 Health and Safety Training Companies list ...
(Date:9/19/2017)... ... September 19, 2017 , ... The ... annual PAINWeek National Conference. On October 7, at the Hilton Providence, 21 Atwells ... program providing busy clinicians and allied healthcare practitioners with 6.0 hours of relevant, ...
(Date:9/19/2017)... Boca Raton (PRWEB) , ... September 19, 2017 ... ... under the El Naturalista brand, developed by ACPG Laboratories, is coming soon to ... years in Spain, and El Naturalista is a trusted, well-respected brand reliant on ...
Breaking Medicine News(10 mins):