Navigation Links
Data Published by Researchers from The Scripps Research Institute Demonstrate Potential for MYC Inhibitor Licensed by Sorrento Therapeutics
Date:8/18/2014

SAN DIEGO, Aug. 18, 2014 /PRNewswire/ -- Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento), a late-stage clinical oncology company developing new treatments for cancer and its associated pain, today announced that data published in the Proceedings of the National Academy of Sciences (PNAS)1 demonstrate the potential for the MYC inhibitors that Sorrento licensed from The Scripps Research Institute (TSRI)2. The TSRI research team, led by Professors Kim D. Janda and Peter K. Vogt, reported in the study that function of the MYC regulator could be inhibited with small molecule compounds in cell culture and importantly in an experimental cancer animal model.

The MYC protein is a transcriptional factor, meaning it controls gene expression and has been recognized as an important determinant of cancer metabolism and protein synthesis. It is involved as a dominant factor in most human cancers and is rarely mutated, but rather its "gain of function" results from overexpression or gene amplification. Abnormal MYC activity is believed to be a key factor in breast, lung, colon, hematologic and other cancers, including Burkitt's lymphoma, a fast-growing cancer that tends to strike children.

The small molecule MYC inhibitors interfere with the protein-protein interaction (PPI) between MYC and its obligatory dimerization partner, Max, preventing sequence-specific binding to DNA and subsequent initiation of oncogenic transformation. The unregulated expression of genes involved in cell proliferation, a key step in cancer growth, follows.

On July 21, 2014, Sorrento announced that preclinical development of a MYC inhibitor would be supported by a Phase 1 Small Business Technology Transfer Research (STTR) grant received from the National Cancer Institute (NCI), a
'/>"/>

SOURCE Sorrento Therapeutics, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers
2. Newly-Published Study Confirms Stretta to be Valuable GERD Treatment
3. Newly Published Survey Shows Drug Shortages Still Have Major Impact on Patient Care
4. Romosozumab Phase 2 Data Published In New England Journal Of Medicine Show Significant Increases In Bone Mineral Density At Both Spine And Hip
5. Ibrutinib Data Published in The Lancet Oncology Suggest a Positive Effect in Previously Untreated Chronic Lymphocytic Leukemia Patients Over Age 65
6. Paper Published in American Journal of Cardiology Demonstrates Favorable Vascular Healing Following MiStent SES Implantation
7. New Findings Published In Circulation: Heart Failure Show Potential Utility Of Cardioxyls HNO Donors As Novel Treatments For Heart Failure
8. Case Report on 14-Year-Old Pediatric Patient Bridged to Transplant with SynCardia Total Artificial Heart Published in the Journal Perfusion
9. KaloBios KB001 Anti-Pseudomonas Antibody Study Published in Pediatric Pulmonology
10. New Edition of Popular Guide to Health Economic Evaluation Published by OHE
11. Newly-Published Study Concludes Stretta May Be More Desirable GERD Treatment than Chronic PPI Use or Anti-Reflux Surgery in Some Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... March 26, 2015 According ... Drug Safety Software Market by Functionality (Adverse Event Reporting, ... (SAAS)), End-user (Pharma & Biotech Companies, CROs, BPOs) ... the Pharmacovigilance and Drug Safety Software Market is ... during 2014-2019, and is expected to reach a ...
(Date:3/26/2015)... , March 26, 2015 DePuy Synthes ... with Radlink, Inc., an emerging global leader in ... guidance with its hip replacement systems. The agreement ... help improve patient outcomes, increase patient satisfaction and ... the 81st annual meeting of the American Academy ...
(Date:3/26/2015)... Mass. , March 26, 2015 /PRNewswire/ ... announced that it will present preclinical and ... at the 2015 American Association for Cancer ... 18-22, 2015 at the Pennsylvania Convention Center in Philadelphia. The presentations ... engineering and nanoliposomal technology platforms, as well ...
Breaking Medicine Technology:Pharmacovigilance and Drug Safety Software Market Worth $154.1 Million by 2019 2Pharmacovigilance and Drug Safety Software Market Worth $154.1 Million by 2019 3Pharmacovigilance and Drug Safety Software Market Worth $154.1 Million by 2019 4DePuy Synthes Companies Announces Exclusive Agreement With Radlink To Help Address Key Challenges In Hip Replacement 2DePuy Synthes Companies Announces Exclusive Agreement With Radlink To Help Address Key Challenges In Hip Replacement 3Merrimack to Highlight Extensive Oncology Pipeline at the 2015 American Association for Cancer Research Annual Meeting 2Merrimack to Highlight Extensive Oncology Pipeline at the 2015 American Association for Cancer Research Annual Meeting 3
... of the tools used to prevent deep vein ... putting patients at,risk for potentially-deadly blood clots, according ... findings appear in the September issue of the ... increased risk for blood clots after surgery,because blood ...
... Pa., Aug. 19 Particle Sciences Inc. ... and,pilot production capabilities with the installation of ... core of the pilot line,comprising a Haake ... enables the production of high-quality drug loaded ...
Cached Medicine Technology:Dallas Researchers Find Compression Stockings Improperly Used 2Particle Sciences Expands Its Combination Product Capabilities 2
(Date:3/26/2015)... FL (PRWEB) March 26, 2015 Florida Hospital ... Taking Action For Your Health campaign and live Dr. Oz ... on Saturday, March 21st. More than a thousand people came ... of healthy living. , The world renowned cardiothoracic surgeon ... News anchor Linda Hurtado and a panel of experts for ...
(Date:3/26/2015)... NJ (PRWEB) March 26, 2015 ... statistical consulting firm, announced the release of BathroomMap® ... experts to increase access to public restrooms for travelers, ... in bathroom apps, BathroomMap does not facilitate a paid, ... algorithm to identify and rate local establishments that have ...
(Date:3/26/2015)... Dr. Alex Rabinovich and his San Francisco ... for Bay Area patients considering dental implants or teeth ... been a top-rated center, serving primarily San Franciscans; however, ... strong demand by others throughout Northern California. , “We ... implant facility in San Francisco,”explained Dr. Alex Rabinovich, owner ...
(Date:3/26/2015)... Mirada, CA (PRWEB) March 26, 2015 ... shooting guard Wesley Matthews is out for the season ... This injury occurred while the Trail Blazers were competing ... sports medicine specialist, Izzy Silva, M.D., who ... on Matthews' injury and whether it could be prevented. ...
(Date:3/26/2015)... Topsfield, MA (PRWEB) March 26, 2015 ... faced by Skilled Nursing and Assisted Living facilities ... and policy changes during the year. The ... Rehabilitation Therapists, MDS coordinators, CNA’s and the ... the Harmony Healthcare International website ( http://www.harmony-healthcare.com ) ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 2Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 3Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 2Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 3Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 3Health News:Sports Medicine Specialist Weighs In on Wesley Matthew’s Significant Tendon Injury; Can it be Prevented? 2Health News:Sports Medicine Specialist Weighs In on Wesley Matthew’s Significant Tendon Injury; Can it be Prevented? 3Health News:Sports Medicine Specialist Weighs In on Wesley Matthew’s Significant Tendon Injury; Can it be Prevented? 4Health News:Harmony Healthcare International Releases 2015 Post Acute Care Trends Report 2Health News:Harmony Healthcare International Releases 2015 Post Acute Care Trends Report 3
... (HealthDay News) -- Children born to mothers with postpartum depression ... hormone called oxytocin may reduce the risk, according to a ... body and has been associated with feelings of love and ... maternal depression, the researchers found. A synthetic version of the ...
... HealthDay Reporter , FRIDAY, Dec. 9 (HealthDay News) ... more form of entertainment. But for Katie Sweeney and her ... celebration. "It was absolute redemption," said Sweeney, recalling the ... Dylan, and 14-year-old son Dusty -- who has autism -- ...
... Centre for Reviews and Dissemination (CRD) at the University ... Health is a new online service provided by the ... National Library of Medicine (NLM) the world,s largest ... of selected systematic reviews and also provides information for ...
... GREENVILLE, S.C. From their fourth-floor state-of-the-art laboratory in ... University bioengineering scientists and students help keep the feet ... new facility, which opens this week, houses one of ... hip, knee and other artificial joints that were removed ...
... mobility of registered nurses (RNs) recently published in the December ... lack of mobility has serious implications for access to health ... studypart of the RN Work Project funded by the Robert ... RNs work within 40 miles of where they attended high ...
... a certain form of inherited hearing loss have ... a study by Professor Thomas Jentsch of the ... Molecular Medicine (MDC) Berlin-Buch and Professor Gary Lewin ... Spain and Nijmegen, the Netherlands. The research findings, ...
Cached Medicine News:Health News:'Love Hormone' May Buffer Kids From Mom's Depression 2Health News:Broadway Strikes an Autism-Friendly Chord 2Health News:Broadway Strikes an Autism-Friendly Chord 3Health News:Broadway Strikes an Autism-Friendly Chord 4Health News:Clemson University opens bioengineering research lab at Greenville hospital campus 2Health News:Clemson University opens bioengineering research lab at Greenville hospital campus 3Health News:New registered nurses' lack of geographic mobility has negative implications for rural health 2Health News:New registered nurses' lack of geographic mobility has negative implications for rural health 3Health News:People with DFNA2 hearing loss show increased touch sensitivity 2Health News:People with DFNA2 hearing loss show increased touch sensitivity 3
... five different models. Choose mechanical or gravity ... liters), 2.5 cu. Ft. (71.5 liters), or ... Precision Economy Incubators combine a wide temperature ... uniformity. As a result, you will find ...
... Incubators. Bench top incubators use minimum ... Aluminum lined chamber provides excellent temperature ... contain removable perforated floor shelf and ... port on top of incubator permits ...
Binocular indirect ophthalmic lenses. Pediatric ophthalmoscopy / vetinary applications....
Binocular indirect ophthalmic lenses. Small pupil diagnosis & treatment....
Medicine Products: