Navigation Links
Data Published by Researchers from The Scripps Research Institute Demonstrate Potential for MYC Inhibitor Licensed by Sorrento Therapeutics
Date:8/18/2014

SAN DIEGO, Aug. 18, 2014 /PRNewswire/ -- Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento), a late-stage clinical oncology company developing new treatments for cancer and its associated pain, today announced that data published in the Proceedings of the National Academy of Sciences (PNAS)1 demonstrate the potential for the MYC inhibitors that Sorrento licensed from The Scripps Research Institute (TSRI)2. The TSRI research team, led by Professors Kim D. Janda and Peter K. Vogt, reported in the study that function of the MYC regulator could be inhibited with small molecule compounds in cell culture and importantly in an experimental cancer animal model.

The MYC protein is a transcriptional factor, meaning it controls gene expression and has been recognized as an important determinant of cancer metabolism and protein synthesis. It is involved as a dominant factor in most human cancers and is rarely mutated, but rather its "gain of function" results from overexpression or gene amplification. Abnormal MYC activity is believed to be a key factor in breast, lung, colon, hematologic and other cancers, including Burkitt's lymphoma, a fast-growing cancer that tends to strike children.

The small molecule MYC inhibitors interfere with the protein-protein interaction (PPI) between MYC and its obligatory dimerization partner, Max, preventing sequence-specific binding to DNA and subsequent initiation of oncogenic transformation. The unregulated expression of genes involved in cell proliferation, a key step in cancer growth, follows.

On July 21, 2014, Sorrento announced that preclinical development of a MYC inhibitor would be supported by a Phase 1 Small Business Technology Transfer Research (STTR) grant received from the National Cancer Institute (NCI), a
'/>"/>

SOURCE Sorrento Therapeutics, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers
2. Newly-Published Study Confirms Stretta to be Valuable GERD Treatment
3. Newly Published Survey Shows Drug Shortages Still Have Major Impact on Patient Care
4. Romosozumab Phase 2 Data Published In New England Journal Of Medicine Show Significant Increases In Bone Mineral Density At Both Spine And Hip
5. Ibrutinib Data Published in The Lancet Oncology Suggest a Positive Effect in Previously Untreated Chronic Lymphocytic Leukemia Patients Over Age 65
6. Paper Published in American Journal of Cardiology Demonstrates Favorable Vascular Healing Following MiStent SES Implantation
7. New Findings Published In Circulation: Heart Failure Show Potential Utility Of Cardioxyls HNO Donors As Novel Treatments For Heart Failure
8. Case Report on 14-Year-Old Pediatric Patient Bridged to Transplant with SynCardia Total Artificial Heart Published in the Journal Perfusion
9. KaloBios KB001 Anti-Pseudomonas Antibody Study Published in Pediatric Pulmonology
10. New Edition of Popular Guide to Health Economic Evaluation Published by OHE
11. Newly-Published Study Concludes Stretta May Be More Desirable GERD Treatment than Chronic PPI Use or Anti-Reflux Surgery in Some Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... An aggressive campaign to reduce the unnecessary ... infection with a dangerous drug-resistant bacteria at The Valley ... or C.diff, is a bacterium that can cause symptoms ... A recent article in the New England Journal of ... the United States " asserts that "C. ...
(Date:2/27/2015)... ON , Feb. 27, 2015 /CNW/ - Covalon Technologies ... medical technologies company, today announced financial results for its ... For the three months ended December 31, 2014, revenue ... the quarter was $229,820 or $0.02 per share.  ... , said "I am very pleased with the significant ...
(Date:2/27/2015)... 2015  Bionik Laboratories Corp. (OTC:DWTPD), a ... it acquired Bionik Laboratories, Inc., a Toronto ... to qualified accredited investors of units consisting of its ... approximately $6.2 million. Shares of the Company,s common stock ... under the symbol "DWTPD" until FINRA,s approval of the ...
Breaking Medicine Technology:Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 3Covalon Announces First Quarter Financial Results 2Covalon Announces First Quarter Financial Results 3Bionik Laboratories Raises $6.2 Million 2Bionik Laboratories Raises $6.2 Million 3
... 6, 2011 The U.S. Food and Drug Administration ... (metastatic) medullary thyroid cancer who are ineligible for surgery ... symptoms. (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... the thyroid gland, which is located in the neck. ...
... April 6, 2011 Quest Diagnostics Incorporated (NYSE: ... testing, information and services, today announced that the Simplexa™ ... with a bronze award for best new science and ... ceremony last night in New York City. Focus Diagnostics, ...
Cached Medicine Technology:FDA Approves New Treatment for Rare Form of Thyroid Cancer 2FDA Approves New Treatment for Rare Form of Thyroid Cancer 3Quest Diagnostics Honored for Diagnostic Innovation at 2011 Edison Awards 2Quest Diagnostics Honored for Diagnostic Innovation at 2011 Edison Awards 3
(Date:3/1/2015)... Ticket Down is a reputable source for ... Soldier Field. Deadheads have been anxiously anticipating this blockbuster ... Dead was formed 50 years ago back in the 60s ... until the untimely death of Jerry Garcia in 1995. ... blues, reggae, rock, bluegrass, folk, space rock and country to ...
(Date:3/1/2015)... Aliso Viejo, California (PRWEB) March 01, 2015 ... have announced a new transition pack for ... users to add accordion style transitions to any FCPX ... Studios. “We’ve given our users the tools needed to ... FCPX media.” , The user gets many different controls ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 In a ... Fletcher of Game Change Athlete Development ... Leinert about the benefits of athlete development and player ... of the unique challenges that athletes face and how ... future success. , Fletcher became involved in athlete development ...
(Date:2/28/2015)... March—also known as National Brain Injury ... and others that suspected head injuries, especially concussions, ... , Concussions are a form of traumatic brain ... There are 1.6-3.8 million sports-related concussions per year. ... is a brain injury. Many athletes suffer knee ...
(Date:2/28/2015)... For those people who are unable ... Mesothelioma Applied Research Foundation (Meso Foundation) will broadcast ... starting at 9:30 AM. , The live broadcast is ... can be accessed through any browser on a computer ... Symposium is a unique event that covers important treatment ...
Breaking Medicine News(10 mins):Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Ticket Prices in Chicago at Soldier Field for 4th of July Weekend Celebration 2Health News:Announcing a New Transition Pack from Pixel Film Studios, Transccordion for Final Cut Pro X 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3Health News:Atlantic NeuroSurgical Specialists (ANS) Focus on National Brain Injury Awareness Month to Educate the General Public on Head Trauma 2Health News:Atlantic NeuroSurgical Specialists (ANS) Focus on National Brain Injury Awareness Month to Educate the General Public on Head Trauma 3Health News:Mesothelioma Cancer Research Foundation Broadcasting Symposium Live 2
... -- The cost of health care is a hot-button issue ... that health insurance premiums for individuals vary widely around the ... the United States in 2010 was $215, researchers from the ... vary by up to $300 from state to state. ...
... Hamilton, ON (August 17, 2011) Active children ... effective way of countering dehydration than a sports drink ... That,s particularly important during hot summer weather, says Brian ... Medicine Program at McMaster and principal investigator of the ...
... Patients with clinically diagnosed superficial vein thrombosis (SVT), a blood ... resolves on its own without treatment, are four to six ... often life-threatening condition, according to study results published ... the American Society of Hematology (ASH). Recent ...
... latex allergy in health care workers have demonstrated the ... is by stopping the use of powdered latex gloves. ... latex allergy to powdered latex glove use but were ... workers. Reducing the use of powdered gloves reduced the ...
... Minn. Mayo Clinic has received investigational ... the Food and Drug Administration ( http://www.fda.gov/ ... mobilize the body,s defense mechanisms to destroy ... first aimed at preventing cancer recurrence. The ...
... (HealthDay News) -- Many drugs already approved to combat certain ... other seemingly unrelated health problems, a new study indicates. ... computers to pair drugs with all illnesses for which they ... for drug repositioning -- or the use of existing drugs ...
Cached Medicine News:Health News:Cost of Health Coverage in U.S. May Depend on Where You Live 2Health News:Common vein condition increases risk for developing life-threating blood clots 2Health News:Using powder-free latex gloves reduces latex allergy rate in health care workers 2Health News:Mayo Clinic receives FDA approval for ovarian and breast cancer vaccines 2Health News:New Uses Found for Old Drugs 2
... Guidant Contak Renewal 3 cardiac ... tachyarrhythmia therapy and cardiac resynchronization ... ventricular (RV) and left ventricular ... to reduce irregular ventricular intervals ...
... Contak Renewal 3 cardiac resynchronization ... therapy and cardiac resynchronization therapy. ... (RV) and left ventricular (LV) ... reduce irregular ventricular intervals during ...
... Contak Renewal 3 cardiac resynchronization ... therapy and cardiac resynchronization therapy. ... (RV) and left ventricular (LV) ... reduce irregular ventricular intervals during ...
... brain biopsy needle guide housing. MRI-compatible. ... mount. Placed through a standard 1.0 ... via autoclave Guide sphere assembly with a ... needles with barium sleeves. Sterile; single-use only ...
Medicine Products: