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Data Presented at the American Heart Association Scientific Sessions 2007 Demonstrated Increased HDL with ACTOS(R) (pioglitazone HCl) Slowed the Progression of Carotid Intima-Media Thickness in Patients with Type 2 Diabetes
Date:11/6/2007

ORLANDO, Fla., Nov. 6 /PRNewswire/ --

What and When

Additional results from the clinical trial, CHICAGO (Carotid intima-media tHICkness in Atherosclerosis using pioGlitazOne), will be presented as an oral session at the American Heart Association Scientific Sessions 2007 being held November 4 through 7, 2007 in Orlando, Florida.

Results revealed that reduced progression of carotid intima-media thickness (CIMT), the thickness of the inner lining of a patient's carotid, with ACTOS was associated with increased HDL cholesterol and decreased insulin levels when compared to glimepiride. An increase in CIMT is an indicator of atherosclerosis, a condition that leads to reduced or blocked blood flow and is a surrogate marker for the risk of heart attack and stroke.

CHICAGO is the largest and longest study to examine the effects of ACTOS on measures of the atherosclerotic disease process in patients with type 2 diabetes. The randomized, double-blind, controlled study enrolled 462 patients with type 2 diabetes. Patients were treated with a 15 to 45 mg dose of ACTOS or 1 to 4 mg dose of glimepiride for 72 weeks with evaluation after 6 months. The results from the CHICAGO study demonstrated significant improvements on cardiovascular risk markers beyond glycemic control with ACTOS.

The CHICAGO trial adds to the already substantial body of evidence regarding cardiovascular data that has been developed over several years of research on ACTOS.

Oral presentation on November 6, 2007 from

9:15 to 9:30 a.m. Eastern Standard Time

About ACTOS

ACTOS works by directly targeting insulin resistance, a condition in which the body does not efficiently use the insulin it produces to control blood glucose levels. ACTOS, a prescription medication, is taken once daily as an adjunct to diet and exercise, and is approved for use for type 2 diabetes as monotherapy to lower blood glucose and in combination therapy with insulin, sulfonylureas
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SOURCE Takeda Pharmaceuticals North America, Inc.
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