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Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions
Date:5/25/2011

160;Allergic reactions associated with ENBREL administration have been reported.  If any serious allergic or anaphylactic reaction occurs, discontinue administration of ENBREL immediately.

There have been rare reports of CNS demyelinating disorders in patients treated with ENBREL.

Rare cases of pancytopenia, and very rare cases of aplastic anemia, some fatal, have been reported in patients treated with ENBREL.  Exercise caution in patients who have a previous history of blood dyscrasias.  Advise patients to seek immediate medical attention if they develop signs or symptoms of blood dyscrasias or infection.  If blood dyscrasias are confirmed, discontinue ENBREL.

Reactivation of hepatitis B virus (HBV) in patients who are chronic carriers of this virus who are receiving anti-TNF agents, including ENBREL, has been reported.  Patients at risk for HBV infection should be evaluated for prior evidence of the virus before initiating anti-TNF therapy.  Although a causal relationship has not been established for ENBREL, caution should be exercised when administering ENBREL for patients identified as carriers for HBV.

There have been reports of worsening of hepatitis C in patients receiving ENBREL, although a causal relationship with ENBREL has not been established.

Physicians should use caution when using ENBREL in patients who also have moderate to severe alcoholic hepatitis.

About Amgen and PfizerAmgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, bone disease and other serious illnesses. With a deep and broa
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